Vaccination contribute to the development of personal and herd immunity
The present article adduces the evidence in support of the need in the development of personalized vaccines and provides with case studies, substantiating the possibility of the mentioned approach. In order to personalize vaccines one should perform preliminary determination of antibody titers (or d...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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Ministry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products»
2018-02-01
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| Series: | Биопрепараты: Профилактика, диагностика, лечение |
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| Online Access: | https://www.biopreparations.ru/jour/article/view/66 |
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| _version_ | 1849342768529276928 |
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| author | N. V. Medunitsyn Yu. V. Olefir V. A. Merkulov V. P. Bondarev |
| author_facet | N. V. Medunitsyn Yu. V. Olefir V. A. Merkulov V. P. Bondarev |
| author_sort | N. V. Medunitsyn |
| collection | DOAJ |
| description | The present article adduces the evidence in support of the need in the development of personalized vaccines and provides with case studies, substantiating the possibility of the mentioned approach. In order to personalize vaccines one should perform preliminary determination of antibody titers (or delayed-type hypersensitivity skin testing) and the subsequent correction of the immunity in patients with low titers of protective antibodies or hyperimmunization symptoms. Vaccine personalization does not require serious financial expenses. The article provides with the advantages of vaccine personalization and the measures that should be taken to achieve this goal. The difficulties of the personalization and the ways to overcome them are described in the article. Vaccine personalization does not require serious financial expenses. It will contribute to the development of preventive vaccination. Personalization of vaccines is necessary for achieving herd immunity, which leads to the reduction in the incidence of the mentioned infection and usually to the reduction of agent circulation. «Immune domain», which includes mostly recovered and vaccinated patients as well as naturally immuned individuals (by circulating infectious agents), plays a decisive role in the development of herd immunity. The effectiveness of herd immunity is reduced due to genetic variability of an agent, frequent vaccination refusals and rejections. Long-term herd immunity is stipulated by immunological memory. |
| format | Article |
| id | doaj-art-ab21f28c6044456bba5e3ccfd417ff7c |
| institution | Kabale University |
| issn | 2221-996X 2619-1156 |
| language | Russian |
| publishDate | 2018-02-01 |
| publisher | Ministry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» |
| record_format | Article |
| series | Биопрепараты: Профилактика, диагностика, лечение |
| spelling | doaj-art-ab21f28c6044456bba5e3ccfd417ff7c2025-08-20T03:43:15ZrusMinistry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products»Биопрепараты: Профилактика, диагностика, лечение2221-996X2619-11562018-02-0116419520766Vaccination contribute to the development of personal and herd immunityN. V. Medunitsyn0Yu. V. Olefir1V. A. Merkulov2V. P. Bondarev3Scientific Centre for Expert Evaluation of Medicinal ProductsScientific Centre for Expert Evaluation of Medicinal ProductsScientific Centre for Expert Evaluation of Medicinal ProductsScientific Centre for Expert Evaluation of Medicinal ProductsThe present article adduces the evidence in support of the need in the development of personalized vaccines and provides with case studies, substantiating the possibility of the mentioned approach. In order to personalize vaccines one should perform preliminary determination of antibody titers (or delayed-type hypersensitivity skin testing) and the subsequent correction of the immunity in patients with low titers of protective antibodies or hyperimmunization symptoms. Vaccine personalization does not require serious financial expenses. The article provides with the advantages of vaccine personalization and the measures that should be taken to achieve this goal. The difficulties of the personalization and the ways to overcome them are described in the article. Vaccine personalization does not require serious financial expenses. It will contribute to the development of preventive vaccination. Personalization of vaccines is necessary for achieving herd immunity, which leads to the reduction in the incidence of the mentioned infection and usually to the reduction of agent circulation. «Immune domain», which includes mostly recovered and vaccinated patients as well as naturally immuned individuals (by circulating infectious agents), plays a decisive role in the development of herd immunity. The effectiveness of herd immunity is reduced due to genetic variability of an agent, frequent vaccination refusals and rejections. Long-term herd immunity is stipulated by immunological memory.https://www.biopreparations.ru/jour/article/view/66вакцинывакцинациядифференцированный подходкоррекция иммунитетазащитные титры антителиндивидуализация (персонализация) вакцинацииvaccinesvaccinationdifferentiated approachcorrection of immunityprotective antibody titersvaccination personalization |
| spellingShingle | N. V. Medunitsyn Yu. V. Olefir V. A. Merkulov V. P. Bondarev Vaccination contribute to the development of personal and herd immunity Биопрепараты: Профилактика, диагностика, лечение вакцины вакцинация дифференцированный подход коррекция иммунитета защитные титры антител индивидуализация (персонализация) вакцинации vaccines vaccination differentiated approach correction of immunity protective antibody titers vaccination personalization |
| title | Vaccination contribute to the development of personal and herd immunity |
| title_full | Vaccination contribute to the development of personal and herd immunity |
| title_fullStr | Vaccination contribute to the development of personal and herd immunity |
| title_full_unstemmed | Vaccination contribute to the development of personal and herd immunity |
| title_short | Vaccination contribute to the development of personal and herd immunity |
| title_sort | vaccination contribute to the development of personal and herd immunity |
| topic | вакцины вакцинация дифференцированный подход коррекция иммунитета защитные титры антител индивидуализация (персонализация) вакцинации vaccines vaccination differentiated approach correction of immunity protective antibody titers vaccination personalization |
| url | https://www.biopreparations.ru/jour/article/view/66 |
| work_keys_str_mv | AT nvmedunitsyn vaccinationcontributetothedevelopmentofpersonalandherdimmunity AT yuvolefir vaccinationcontributetothedevelopmentofpersonalandherdimmunity AT vamerkulov vaccinationcontributetothedevelopmentofpersonalandherdimmunity AT vpbondarev vaccinationcontributetothedevelopmentofpersonalandherdimmunity |