Re-visiting mpox: Stealth assault on the brain and emerging biomedical research insights
The recent global outbreak of mpox virus (MPXV) infections has reignited interest in this zoonotic disease, mpox. As of August 2024, mpox continues to pose significant global health challenges, with ongoing transmission in Africa, the Americas, and Europe. This article examines the neurological impl...
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| Language: | English |
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Elsevier
2024-12-01
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| Series: | Brain Disorders |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666459324000544 |
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| author | Abhimanyu Thakur |
| author_facet | Abhimanyu Thakur |
| author_sort | Abhimanyu Thakur |
| collection | DOAJ |
| description | The recent global outbreak of mpox virus (MPXV) infections has reignited interest in this zoonotic disease, mpox. As of August 2024, mpox continues to pose significant global health challenges, with ongoing transmission in Africa, the Americas, and Europe. This article examines the neurological implications of MPXV infection, synthesizing current research to provide biomedical insights into the virus's potential impact on the central nervous system (CNS). The neuroinvasive potential of MPXV and the rare but serious complication of encephalomyelitis have been discussed. The article explores advances in mpox research, including insights from animal models such as dogs, squirrels, and mice. Further. the application of bioinformatics and machine learning techniques for enhanced mpox detection and potential therapeutics for mpox and related neurological complications have discussed. The article also addresses the current state of mpox vaccines, existing resources, and future directions for vaccine development. By examining the molecular characteristics of MPXV, its mechanisms of cellular invasion, and its effects beyond cutaneous manifestations, this article provides a comprehensive overview of the current understanding of mpox neurological implications. Eventually, the major research priorities and potential strategies for mitigating the neurological impact of MPXV infections have been highlighted in the context of ongoing global health challenges. |
| format | Article |
| id | doaj-art-ab1ddf64648e4c058fa71d284ede7fcd |
| institution | Kabale University |
| issn | 2666-4593 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Disorders |
| spelling | doaj-art-ab1ddf64648e4c058fa71d284ede7fcd2024-12-04T05:13:58ZengElsevierBrain Disorders2666-45932024-12-0116100169Re-visiting mpox: Stealth assault on the brain and emerging biomedical research insightsAbhimanyu Thakur0Department of Pharmacology, Delhi Pharmaceutical Sciences and Research University, New Delhi, IndiaThe recent global outbreak of mpox virus (MPXV) infections has reignited interest in this zoonotic disease, mpox. As of August 2024, mpox continues to pose significant global health challenges, with ongoing transmission in Africa, the Americas, and Europe. This article examines the neurological implications of MPXV infection, synthesizing current research to provide biomedical insights into the virus's potential impact on the central nervous system (CNS). The neuroinvasive potential of MPXV and the rare but serious complication of encephalomyelitis have been discussed. The article explores advances in mpox research, including insights from animal models such as dogs, squirrels, and mice. Further. the application of bioinformatics and machine learning techniques for enhanced mpox detection and potential therapeutics for mpox and related neurological complications have discussed. The article also addresses the current state of mpox vaccines, existing resources, and future directions for vaccine development. By examining the molecular characteristics of MPXV, its mechanisms of cellular invasion, and its effects beyond cutaneous manifestations, this article provides a comprehensive overview of the current understanding of mpox neurological implications. Eventually, the major research priorities and potential strategies for mitigating the neurological impact of MPXV infections have been highlighted in the context of ongoing global health challenges.http://www.sciencedirect.com/science/article/pii/S2666459324000544Brain disorderMonkeypox virus (MPXV)Mpox outbreakNeurological complications |
| spellingShingle | Abhimanyu Thakur Re-visiting mpox: Stealth assault on the brain and emerging biomedical research insights Brain Disorders Brain disorder Monkeypox virus (MPXV) Mpox outbreak Neurological complications |
| title | Re-visiting mpox: Stealth assault on the brain and emerging biomedical research insights |
| title_full | Re-visiting mpox: Stealth assault on the brain and emerging biomedical research insights |
| title_fullStr | Re-visiting mpox: Stealth assault on the brain and emerging biomedical research insights |
| title_full_unstemmed | Re-visiting mpox: Stealth assault on the brain and emerging biomedical research insights |
| title_short | Re-visiting mpox: Stealth assault on the brain and emerging biomedical research insights |
| title_sort | re visiting mpox stealth assault on the brain and emerging biomedical research insights |
| topic | Brain disorder Monkeypox virus (MPXV) Mpox outbreak Neurological complications |
| url | http://www.sciencedirect.com/science/article/pii/S2666459324000544 |
| work_keys_str_mv | AT abhimanyuthakur revisitingmpoxstealthassaultonthebrainandemergingbiomedicalresearchinsights |