Autism-Linked Mutations in α<sub>2</sub>δ-1 and α<sub>2</sub>δ-3 Reduce Protein Membrane Expression but Affect Neither Calcium Channels nor Trans-Synaptic Signaling

Autism-Linked Mutations in α<sub>2</sub>δ-1 and α<sub>2</sub>δ-3 Reduce Protein Membrane Expression but Affect Neither Calcium Channels nor Trans-Synaptic Signaling

Background: α<sub>2</sub>δ proteins regulate membrane trafficking and biophysical properties of voltage-gated calcium channels. Moreover, they modulate axonal wiring, synapse formation, and trans-synaptic signaling. Several rare missense variants in CACNA2D1 (coding for α<sub>2<...

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Bibliographic Details
Main Authors: Sabrin Haddad, Manuel Hessenberger, Cornelia Ablinger, Clarissa Eibl, Ruslan Stanika, Marta Campiglio, Gerald J. Obermair
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Pharmaceuticals
Subjects:
voltage-gated calcium channels
calcium current
trans-synaptic function
auxiliary subunit
autism spectrum disorder
electrophysiology
Online Access:https://www.mdpi.com/1424-8247/17/12/1608
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