Identification of virus epitopes and reactive T-cell receptors from memory T cells without peptide synthesis

Identification of virus epitopes and reactive T-cell receptors from memory T cells without peptide synthesis

Abstract Identifying epitopes and their corresponding T-cell receptor (TCR) sequences is crucial in the face of rapidly mutating viruses. Peptide synthesis is often required to confirm the exact epitope sequences, which is time-consuming and expensive. In this study, we introduce a scalable workflow...

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Main Authors: Lihui Wang, Runda Xu, Daosheng Huang, Pai Peng, Keyong Sun, Jie Hu, Bei-zhong Liu, Liang Fang, Liwen Zhang, Xin Sun, Fei Gu, Ni Tang, Ai-long Huang, Xin Lin, Xun Lan
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-07048-x
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