Genomic characteristics of a Streptococcus suis of ST353 resulting in severe endophthalmitis with bilateral deafness
Abstract. Background:. Streptococcus suis (S. suis) can be transmitted to humans through exposure to pigs or consumption of raw pork and causes serious diseases. Although infection through skin abrasions is considered an important route of transmission, few studies have reported skin injuries in pa...
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Wolters Kluwer Health - Lippincott Williams Wilkins
2025-01-01
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| Series: | Infectious Diseases & Immunity |
| Online Access: | http://journals.lww.com/10.1097/ID9.0000000000000146 |
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| author | Liang Shen Yanfei Tong Shichao Li Yuda Chen Ruhan A Zhen Li Wenling Wang Lijuan Yin Jiuming Zou Ziyong Sun Changcheng Wu Wenjie Tan Haijuan Wang |
| author_facet | Liang Shen Yanfei Tong Shichao Li Yuda Chen Ruhan A Zhen Li Wenling Wang Lijuan Yin Jiuming Zou Ziyong Sun Changcheng Wu Wenjie Tan Haijuan Wang |
| author_sort | Liang Shen |
| collection | DOAJ |
| description | Abstract.
Background:. Streptococcus suis (S. suis) can be transmitted to humans through exposure to pigs or consumption of raw pork and causes serious diseases. Although infection through skin abrasions is considered an important route of transmission, few studies have reported skin injuries in patients during exposure or before infection. This study explored a rare instance of intraocular infection and bilateral deafness caused by S. suis and emphasized the importance of timely diagnosis and treatment to prevent disease progression.
Methods:. The diagnosis was made on the basis of clinical symptoms, imaging, molecular detection, and isolated culture methods. Drug susceptibility testing was conducted to determine the effectiveness of antibiotics. Whole-genome sequencing was used to identify the strain’s sequence type and serotype as well as the presence of pathogenicity islands (PAIs).
Results:. A patient with intraocular infection and bilateral deafness was diagnosed with an S. suis infection. The infection was hypothesized to result from interspecies transmission due to the patient’s occupation and recent skin damage. The isolated strain was sensitive to ampicillin, ceftriaxone, vancomycin, linezolid, levofloxacin, and meropenem. Whole-genome sequencing revealed that the strain belonged to sequence type 353 and serotype 2, showing close similarity to strains isolated from wild boars in Chinese provinces. The strain lacked the 89 complete kb PAI but had a 33 kb PAI with high similarity, potentially indicating variable virulence.
Conclusion:. This study highlights the importance of employing multiple diagnostic strategies for the timely identification and treatment of S. suis infections. The presence of a potentially less virulent strain emphasizes the need for continuous surveillance and monitoring of emerging S. suis infections, particularly in Asian countries with high-risk populations associated with the pig farming industry. |
| format | Article |
| id | doaj-art-aae6ac56c971450dae9af6fe682fc78b |
| institution | Kabale University |
| issn | 2096-9511 2693-8839 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Health - Lippincott Williams Wilkins |
| record_format | Article |
| series | Infectious Diseases & Immunity |
| spelling | doaj-art-aae6ac56c971450dae9af6fe682fc78b2025-01-14T07:30:25ZengWolters Kluwer Health - Lippincott Williams WilkinsInfectious Diseases & Immunity2096-95112693-88392025-01-0151364310.1097/ID9.0000000000000146202501000-00004Genomic characteristics of a Streptococcus suis of ST353 resulting in severe endophthalmitis with bilateral deafnessLiang Shen0Yanfei Tong1Shichao Li2Yuda Chen3Ruhan A4Zhen Li5Wenling Wang6Lijuan Yin7Jiuming Zou8Ziyong Sun9Changcheng Wu10Wenjie Tan11Haijuan Wang1 Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang 441021, Hubei Province, China1 Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang 441021, Hubei Province, China1 Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang 441021, Hubei Province, China2 National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China2 National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China4 Collaborative Innovation Centre of Regenerative Medicine and Medical BioResourse Development and Application Co-constructed by the Province and Ministry, Guangxi Medical University, Nanning 530021, Guangxi Province, China2 National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China5 State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Microbiology, Ministry of Education, Tianjin Key Laboratory of Industry Microbiology, National and Local United Engineering Lab of Metabolic Control Fermentation Technology, China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, China1 Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang 441021, Hubei Province, China6 Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China2 National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China2 National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaAbstract. Background:. Streptococcus suis (S. suis) can be transmitted to humans through exposure to pigs or consumption of raw pork and causes serious diseases. Although infection through skin abrasions is considered an important route of transmission, few studies have reported skin injuries in patients during exposure or before infection. This study explored a rare instance of intraocular infection and bilateral deafness caused by S. suis and emphasized the importance of timely diagnosis and treatment to prevent disease progression. Methods:. The diagnosis was made on the basis of clinical symptoms, imaging, molecular detection, and isolated culture methods. Drug susceptibility testing was conducted to determine the effectiveness of antibiotics. Whole-genome sequencing was used to identify the strain’s sequence type and serotype as well as the presence of pathogenicity islands (PAIs). Results:. A patient with intraocular infection and bilateral deafness was diagnosed with an S. suis infection. The infection was hypothesized to result from interspecies transmission due to the patient’s occupation and recent skin damage. The isolated strain was sensitive to ampicillin, ceftriaxone, vancomycin, linezolid, levofloxacin, and meropenem. Whole-genome sequencing revealed that the strain belonged to sequence type 353 and serotype 2, showing close similarity to strains isolated from wild boars in Chinese provinces. The strain lacked the 89 complete kb PAI but had a 33 kb PAI with high similarity, potentially indicating variable virulence. Conclusion:. This study highlights the importance of employing multiple diagnostic strategies for the timely identification and treatment of S. suis infections. The presence of a potentially less virulent strain emphasizes the need for continuous surveillance and monitoring of emerging S. suis infections, particularly in Asian countries with high-risk populations associated with the pig farming industry.http://journals.lww.com/10.1097/ID9.0000000000000146 |
| spellingShingle | Liang Shen Yanfei Tong Shichao Li Yuda Chen Ruhan A Zhen Li Wenling Wang Lijuan Yin Jiuming Zou Ziyong Sun Changcheng Wu Wenjie Tan Haijuan Wang Genomic characteristics of a Streptococcus suis of ST353 resulting in severe endophthalmitis with bilateral deafness Infectious Diseases & Immunity |
| title | Genomic characteristics of a Streptococcus suis of ST353 resulting in severe endophthalmitis with bilateral deafness |
| title_full | Genomic characteristics of a Streptococcus suis of ST353 resulting in severe endophthalmitis with bilateral deafness |
| title_fullStr | Genomic characteristics of a Streptococcus suis of ST353 resulting in severe endophthalmitis with bilateral deafness |
| title_full_unstemmed | Genomic characteristics of a Streptococcus suis of ST353 resulting in severe endophthalmitis with bilateral deafness |
| title_short | Genomic characteristics of a Streptococcus suis of ST353 resulting in severe endophthalmitis with bilateral deafness |
| title_sort | genomic characteristics of a streptococcus suis of st353 resulting in severe endophthalmitis with bilateral deafness |
| url | http://journals.lww.com/10.1097/ID9.0000000000000146 |
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