Potential utility of the fatty liver index as a predictor of erectile dysfunction and its severity
Abstract Purpose The aim of this study was to evaluate the relationship between Fatty Liver Index(FLI) and Erectile Dysfunction(ED) and its severity. Materials and methods A group of 230 male patients with ED complaints underwent evaluation. Comprehensive routine blood serum tests were conducted to...
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BMC
2025-07-01
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| Series: | BMC Urology |
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| Online Access: | https://doi.org/10.1186/s12894-025-01865-w |
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| author | Huseyin Aytac Ates Emrah Okucu Yusuf Sahin Nejdet Karsiyakali Emre Karabay |
| author_facet | Huseyin Aytac Ates Emrah Okucu Yusuf Sahin Nejdet Karsiyakali Emre Karabay |
| author_sort | Huseyin Aytac Ates |
| collection | DOAJ |
| description | Abstract Purpose The aim of this study was to evaluate the relationship between Fatty Liver Index(FLI) and Erectile Dysfunction(ED) and its severity. Materials and methods A group of 230 male patients with ED complaints underwent evaluation. Comprehensive routine blood serum tests were conducted to identify potential etiological factors contributing to ED. Additionally, waist circumference(WC) measurements were obtained to facilitate the calculation of the FLI. Participants were also asked to complete the validated Turkish adaptation of the 5-item International Index of Erectile Function (IIEF-5) questionnaire to assess the severity and impact of ED. Results Out of all participants, 55 were classified as non-ED, while 175 were diagnosed with ED, mostly in the mild to moderate category. According to FLI scores, 132 had hepatic steatosis(HS). Body mass index (BMI) and WC were significantly higher in the ED group. Fasting blood glucose, ALT, and triglycerides (TG) were elevated in those with ED, while AST and total testosterone levels were lower. A significant association was found between higher FLI scores and ED (p < 0.05). The FLI score was significantly higher (p < 0.05) in the severe ED group compared to the moderate, mild-moderate, and mild ED groups. Conclusion Based on the results of our study, the FLI appears to be a simple method that shows a high correlation with the severity of ED. We believe that the use of the FLI in the diagnosis and follow-up of ED is noteworthy, and further prospective studies with larger sample sizes are needed to support this conclusion. |
| format | Article |
| id | doaj-art-aad9075a75ab4e76b0b4554795eebbdd |
| institution | Kabale University |
| issn | 1471-2490 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Urology |
| spelling | doaj-art-aad9075a75ab4e76b0b4554795eebbdd2025-08-20T03:46:15ZengBMCBMC Urology1471-24902025-07-012511810.1186/s12894-025-01865-wPotential utility of the fatty liver index as a predictor of erectile dysfunction and its severityHuseyin Aytac Ates0Emrah Okucu1Yusuf Sahin2Nejdet Karsiyakali3Emre Karabay4Department of Urology, Istanbul Training and Research Hospital, Health Sciences UniversityDepartment of Urology, Istanbul Training and Research Hospital, Health Sciences UniversityDepartment of Urology, Istanbul Training and Research Hospital, Health Sciences UniversityDepartment of Urology, School of Medicine, Acıbadem UniversityDepartment of Urology, School of Medicine, Acıbadem UniversityAbstract Purpose The aim of this study was to evaluate the relationship between Fatty Liver Index(FLI) and Erectile Dysfunction(ED) and its severity. Materials and methods A group of 230 male patients with ED complaints underwent evaluation. Comprehensive routine blood serum tests were conducted to identify potential etiological factors contributing to ED. Additionally, waist circumference(WC) measurements were obtained to facilitate the calculation of the FLI. Participants were also asked to complete the validated Turkish adaptation of the 5-item International Index of Erectile Function (IIEF-5) questionnaire to assess the severity and impact of ED. Results Out of all participants, 55 were classified as non-ED, while 175 were diagnosed with ED, mostly in the mild to moderate category. According to FLI scores, 132 had hepatic steatosis(HS). Body mass index (BMI) and WC were significantly higher in the ED group. Fasting blood glucose, ALT, and triglycerides (TG) were elevated in those with ED, while AST and total testosterone levels were lower. A significant association was found between higher FLI scores and ED (p < 0.05). The FLI score was significantly higher (p < 0.05) in the severe ED group compared to the moderate, mild-moderate, and mild ED groups. Conclusion Based on the results of our study, the FLI appears to be a simple method that shows a high correlation with the severity of ED. We believe that the use of the FLI in the diagnosis and follow-up of ED is noteworthy, and further prospective studies with larger sample sizes are needed to support this conclusion.https://doi.org/10.1186/s12894-025-01865-wErectile dysfunctionFatty liver indexHepatosteatosisMetabolic syndrome |
| spellingShingle | Huseyin Aytac Ates Emrah Okucu Yusuf Sahin Nejdet Karsiyakali Emre Karabay Potential utility of the fatty liver index as a predictor of erectile dysfunction and its severity BMC Urology Erectile dysfunction Fatty liver index Hepatosteatosis Metabolic syndrome |
| title | Potential utility of the fatty liver index as a predictor of erectile dysfunction and its severity |
| title_full | Potential utility of the fatty liver index as a predictor of erectile dysfunction and its severity |
| title_fullStr | Potential utility of the fatty liver index as a predictor of erectile dysfunction and its severity |
| title_full_unstemmed | Potential utility of the fatty liver index as a predictor of erectile dysfunction and its severity |
| title_short | Potential utility of the fatty liver index as a predictor of erectile dysfunction and its severity |
| title_sort | potential utility of the fatty liver index as a predictor of erectile dysfunction and its severity |
| topic | Erectile dysfunction Fatty liver index Hepatosteatosis Metabolic syndrome |
| url | https://doi.org/10.1186/s12894-025-01865-w |
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