Protective effects of vitamin e in experimentally induced rhabdomyolysis
<b>Aim:</b> Evaluation of the protective effects of vitamin E administration in a rat model of rhabdomyolysis.<p> <b>Material and Method:</b> Twenty one rats were divided to three equal groups; control (Group 1), glycerol (50% glycerol, 7 mL/kg, IM) and glycerol (50% gl...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1011 |
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| Summary: | <b>Aim:</b> Evaluation of the protective effects of vitamin E administration
in a rat model of rhabdomyolysis.<p>
<b>Material and Method:</b> Twenty one rats were divided to
three equal groups; control (Group 1), glycerol (50% glycerol,
7 mL/kg, IM) and glycerol (50% glycerol, 7 mL/kg, IM) +
Vitamin E (100 mg/kg, IP, SID). Ninety-six hours after glycerol
injection, blood samples were collected. Serum creatinine,
blood urea nitrogen, creatine kinase, aspartate aminotransferase,
alanine aminotransferase and lactate dehydrogenase
levels were measured. Histopathologic pattern of hepatic
and renal tissue damages was also evaluated.<p>
<b>Results:</b> Glycerol + vitamin E groups had lower (P<0.05)
creatinine, lactate dehydrogenase and creatine kinase levels
than the glycerol group, and the administration of vitamin E
caused lesser renal tubular damages in glycerol + vitamin E
group rather than in glycerol group.<p>
<b>Conclusions:</b> Vitamin E administration may decrease the
muscle injury and renal damage in rhabdomyolysis cases. |
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| ISSN: | 1309-6958 2146-1953 |