MTHFD1 Regulates Autophagy to Promote Growth and Metastasis in Colorectal Cancer via the PI3K‐AKT–mTOR Signaling Pathway

ABSTRACT Objectives Methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) is the enzyme with the activities of methylenetetrahydrofolate dehydrogenase, methylenetetrahydrofolate cyclohydrolase, and formyltetrahydrofolate synthetase. Our aim was to elucidate the function of MTHFD1 in colorectal cancer (...

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Bibliographic Details
Main Authors: Zhihao Li, Haoxian Ke, Jiawei Cai, Shubiao Ye, Junfeng Huang, Chi Zhang, Ming Yuan, Ping Lan, Xianrui Wu
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:Cancer Medicine
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Online Access:https://doi.org/10.1002/cam4.70267
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