The Prognostic Role of Systemic Inflammatory Parameters and Severity Scores in Patients with Acute Pancreatitis
Objective: To investigate the predictive power of the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte/eosinophil ratio (MER), and C-reactive protein (CRP) levels, as well as the harmless acute pancreatitis score (HAPS) and modified computed tomography severity index (mCT...
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| Format: | Article |
| Language: | English |
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Türkiye Acil Tıp Vakfı
2024-08-01
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| Series: | Global Emergency and Critical Care |
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| Online Access: | https://globemcc.com/articles/the-prognostic-role-of-systemic-inflammatory-parameters-and-severity-scores-in-patients-with-acute-pancreatitis/doi/globecc.galenos.2023.64936 |
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| author | Tansu Aykan Adem Az Özgür Söğüt Tarık Akdemir Tuba Selçuk Can |
| author_facet | Tansu Aykan Adem Az Özgür Söğüt Tarık Akdemir Tuba Selçuk Can |
| author_sort | Tansu Aykan |
| collection | DOAJ |
| description | Objective: To investigate the predictive power of the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte/eosinophil ratio (MER), and C-reactive protein (CRP) levels, as well as the harmless acute pancreatitis score (HAPS) and modified computed tomography severity index (mCTSI) score, in patients with acute pancreatitis (AP).
Materials and Methods: This retrospective study included adult patients hospitalized for AP. Patients were classified according to disease severity using HAPS and mCTSI. Systemic inflammatory parameters and demographic data were compared among patients to identify factors associated with disease severity.
Results: A total of 442 patients, 199 males (45%) and 243 females (55%), were enrolled in the study. Patients with severe disease had significantly higher mean NLR, PLR, MER, and CRP values than those with mild or moderate disease according to HAPS and mCTSI classifications. Positive correlations were observed between serum NLR, PLR, MER, CRP, and mCTSI. HAPS was correlated with NLR, MER, and CRP. Elevated NLR, MER, and CRP levels were independent predictors of disease severity in patients with AP according to HAPS and mCTSI.
Conclusion: NLR, MER, and CRP levels, but not PLR, in conjunction with HAPS or mCTSI may be useful for clinical decision-making regarding AP severity. |
| format | Article |
| id | doaj-art-aab75b9bddc04c86b430ab1cb8158e99 |
| institution | Kabale University |
| issn | 2822-4078 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Türkiye Acil Tıp Vakfı |
| record_format | Article |
| series | Global Emergency and Critical Care |
| spelling | doaj-art-aab75b9bddc04c86b430ab1cb8158e992024-12-23T13:50:54ZengTürkiye Acil Tıp VakfıGlobal Emergency and Critical Care2822-40782024-08-0132808610.4274/globecc.galenos.2023.64936The Prognostic Role of Systemic Inflammatory Parameters and Severity Scores in Patients with Acute PancreatitisTansu Aykan0https://orcid.org/0000-0002-2251-1843Adem Az1https://orcid.org/0000-0002-7204-6185Özgür Söğüt2https://orcid.org/0000-0003-3365-3713Tarık Akdemir3https://orcid.org/0000-0003-1178-2274Tuba Selçuk Can4https://orcid.org/0000-0002-2388-1715University of Health Sciences Türkiye İstanbul Haseki Training and Research Hospital, Clinic of Emergency Medicine, İstanbul, Türkiyeİstanbul Beylikdüzü State Hospital Clinic of Emergency Medicine, İstanbul, TürkiyeUniversity of Health Sciences Türkiye İstanbul Haseki Training and Research Hospital, Clinic of Emergency Medicine, İstanbul, TürkiyeUniversity of Health Sciences Türkiye İstanbul Haseki Training and Research Hospital, Clinic of Emergency Medicine, İstanbul, TürkiyeUniversity of Health Sciences Türkiye İstanbul Haseki Training and Research Hospital, Clinic of Radiology, İstanbul, TürkiyeObjective: To investigate the predictive power of the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte/eosinophil ratio (MER), and C-reactive protein (CRP) levels, as well as the harmless acute pancreatitis score (HAPS) and modified computed tomography severity index (mCTSI) score, in patients with acute pancreatitis (AP). Materials and Methods: This retrospective study included adult patients hospitalized for AP. Patients were classified according to disease severity using HAPS and mCTSI. Systemic inflammatory parameters and demographic data were compared among patients to identify factors associated with disease severity. Results: A total of 442 patients, 199 males (45%) and 243 females (55%), were enrolled in the study. Patients with severe disease had significantly higher mean NLR, PLR, MER, and CRP values than those with mild or moderate disease according to HAPS and mCTSI classifications. Positive correlations were observed between serum NLR, PLR, MER, CRP, and mCTSI. HAPS was correlated with NLR, MER, and CRP. Elevated NLR, MER, and CRP levels were independent predictors of disease severity in patients with AP according to HAPS and mCTSI. Conclusion: NLR, MER, and CRP levels, but not PLR, in conjunction with HAPS or mCTSI may be useful for clinical decision-making regarding AP severity.https://globemcc.com/articles/the-prognostic-role-of-systemic-inflammatory-parameters-and-severity-scores-in-patients-with-acute-pancreatitis/doi/globecc.galenos.2023.64936acute pancreatitissystemic inflammatory parametersharmless acute pancreatitis scoremodified ct severity index |
| spellingShingle | Tansu Aykan Adem Az Özgür Söğüt Tarık Akdemir Tuba Selçuk Can The Prognostic Role of Systemic Inflammatory Parameters and Severity Scores in Patients with Acute Pancreatitis Global Emergency and Critical Care acute pancreatitis systemic inflammatory parameters harmless acute pancreatitis score modified ct severity index |
| title | The Prognostic Role of Systemic Inflammatory Parameters and Severity Scores in Patients with Acute Pancreatitis |
| title_full | The Prognostic Role of Systemic Inflammatory Parameters and Severity Scores in Patients with Acute Pancreatitis |
| title_fullStr | The Prognostic Role of Systemic Inflammatory Parameters and Severity Scores in Patients with Acute Pancreatitis |
| title_full_unstemmed | The Prognostic Role of Systemic Inflammatory Parameters and Severity Scores in Patients with Acute Pancreatitis |
| title_short | The Prognostic Role of Systemic Inflammatory Parameters and Severity Scores in Patients with Acute Pancreatitis |
| title_sort | prognostic role of systemic inflammatory parameters and severity scores in patients with acute pancreatitis |
| topic | acute pancreatitis systemic inflammatory parameters harmless acute pancreatitis score modified ct severity index |
| url | https://globemcc.com/articles/the-prognostic-role-of-systemic-inflammatory-parameters-and-severity-scores-in-patients-with-acute-pancreatitis/doi/globecc.galenos.2023.64936 |
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