Chemical analysis of Moringa oleifera (Moringaceae) seed oil and potentiation of antibiotic activity against standard and multidrug-resistant bacterial strains
Moringa oleifera (“moringa”) seeds are sources of fixed oil with a composition of fatty acids important for their biological properties. This work aimed to verify the fixed oil of seed, regarding chemical composition, antibacterial activity alone and in association with antibiotics against standard...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
|
| Series: | Food Chemistry Advances |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772753X24001618 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846124908940099584 |
|---|---|
| author | Erlânio Oliveira de Sousa Anielle dos Santos Brito Denise Magalhães Azevedo Feitoza Aureliano de Albuquerque Ribeiro Victória Hellen Nicácio Dias Tavares Mayra Garcia Maia Costa Crisiana de Andrade Nobre Cícera Datiane de Morais Oliveira-Tintino João Arthur de Oliveira Borges Gildênia Alves de Araújo Talysson Felismino Moura João Paulo Martins de Lima Sloana Giesta Lemos Florencio Henrique Douglas Melo Coutinho Irwin Rose Alencar de Menezes Saulo Relison Tintino |
| author_facet | Erlânio Oliveira de Sousa Anielle dos Santos Brito Denise Magalhães Azevedo Feitoza Aureliano de Albuquerque Ribeiro Victória Hellen Nicácio Dias Tavares Mayra Garcia Maia Costa Crisiana de Andrade Nobre Cícera Datiane de Morais Oliveira-Tintino João Arthur de Oliveira Borges Gildênia Alves de Araújo Talysson Felismino Moura João Paulo Martins de Lima Sloana Giesta Lemos Florencio Henrique Douglas Melo Coutinho Irwin Rose Alencar de Menezes Saulo Relison Tintino |
| author_sort | Erlânio Oliveira de Sousa |
| collection | DOAJ |
| description | Moringa oleifera (“moringa”) seeds are sources of fixed oil with a composition of fatty acids important for their biological properties. This work aimed to verify the fixed oil of seed, regarding chemical composition, antibacterial activity alone and in association with antibiotics against standard and multidrug resistant bacterial strains. In the chemical composition of the fixed oil, the unsaturated fatty acids (78.26 %) predominated in relation to saturated fatty acids (17.34 %). The palmitic acid (5.88 %), behenic acid (4.27 %), stearic acid (4.17 %) and oleic acid (74.15 %) were the main constituents. Physicalchemical analyzes for moisture, acidity, pH, relative density, peroxide index and refractive index indicated chemical quality of the oil. We performed docking calculation to prioritize low affinity major molecules present in the chemical composition. The docking result of the all compounds showed that highest binding energy type Hydrogen bond, water hydrogen bond and hydrophobic interaction. The fixed oil did not show antibacterial activity alone with a minimum inhibitory concentration (MIC ≥ 1024 μg/mL) for the analyzed bacterial strains. Synergistic effects were verified in the association of the fixed oil with gentamicin, ofloxacin and penicillin against multiresistant strains, with reductions in MICs. |
| format | Article |
| id | doaj-art-aaa89f84d69e4783835c71fb68eded45 |
| institution | Kabale University |
| issn | 2772-753X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Food Chemistry Advances |
| spelling | doaj-art-aaa89f84d69e4783835c71fb68eded452024-12-13T11:08:49ZengElsevierFood Chemistry Advances2772-753X2024-12-015100765Chemical analysis of Moringa oleifera (Moringaceae) seed oil and potentiation of antibiotic activity against standard and multidrug-resistant bacterial strainsErlânio Oliveira de Sousa0Anielle dos Santos Brito1Denise Magalhães Azevedo Feitoza2Aureliano de Albuquerque Ribeiro3Victória Hellen Nicácio Dias Tavares4Mayra Garcia Maia Costa5Crisiana de Andrade Nobre6Cícera Datiane de Morais Oliveira-Tintino7João Arthur de Oliveira Borges8Gildênia Alves de Araújo9Talysson Felismino Moura10João Paulo Martins de Lima11Sloana Giesta Lemos Florencio12Henrique Douglas Melo Coutinho13Irwin Rose Alencar de Menezes14Saulo Relison Tintino15Laboratory Analysis Physical Chemistry of Food, Faculty of Technology Cariri – Fatec, Juazeiro do Norte, BrazilLaboratory Analysis Physical Chemistry of Food, Faculty of Technology Cariri – Fatec, Juazeiro do Norte, BrazilLaboratory Analysis Physical Chemistry of Food, Faculty of Technology Cariri – Fatec, Juazeiro do Norte, BrazilLaboratory Analysis Physical Chemistry of Food, Faculty of Technology Cariri – Fatec, Juazeiro do Norte, BrazilLaboratory Analysis Physical Chemistry of Food, Faculty of Technology Cariri – Fatec, Juazeiro do Norte, BrazilLaboratory of Instrumental Chemistry, Nucleus of Technology and Industrial Quality of Ceará – Nutec, Fortaleza, BrazilLaboratory of Instrumental Chemistry, Nucleus of Technology and Industrial Quality of Ceará – Nutec, Fortaleza, BrazilLaboratory of Microbiology and Molecular Biology, Regional University of Cariri – URCA, Crato, CE, BrazilLaboratory of Microbiology and Molecular Biology, Regional University of Cariri – URCA, Crato, CE, BrazilLaboratory of Microbiology and Molecular Biology, Regional University of Cariri – URCA, Crato, CE, BrazilLaboratory of Microbiology and Molecular Biology, Regional University of Cariri – URCA, Crato, CE, BrazilCECAPE College of Dentistry, Juazeiro do Norte, Ceara, BrazilCECAPE College of Dentistry, Juazeiro do Norte, Ceara, BrazilLaboratory of Microbiology and Molecular Biology, Regional University of Cariri – URCA, Crato, CE, Brazil; Corresponding author.Laboratory of Pharmacology and Molecular Chemistry, Regional University of Cariri – URCA, Crato, CE, BrazilLaboratory of Microbiology and Molecular Biology, Regional University of Cariri – URCA, Crato, CE, BrazilMoringa oleifera (“moringa”) seeds are sources of fixed oil with a composition of fatty acids important for their biological properties. This work aimed to verify the fixed oil of seed, regarding chemical composition, antibacterial activity alone and in association with antibiotics against standard and multidrug resistant bacterial strains. In the chemical composition of the fixed oil, the unsaturated fatty acids (78.26 %) predominated in relation to saturated fatty acids (17.34 %). The palmitic acid (5.88 %), behenic acid (4.27 %), stearic acid (4.17 %) and oleic acid (74.15 %) were the main constituents. Physicalchemical analyzes for moisture, acidity, pH, relative density, peroxide index and refractive index indicated chemical quality of the oil. We performed docking calculation to prioritize low affinity major molecules present in the chemical composition. The docking result of the all compounds showed that highest binding energy type Hydrogen bond, water hydrogen bond and hydrophobic interaction. The fixed oil did not show antibacterial activity alone with a minimum inhibitory concentration (MIC ≥ 1024 μg/mL) for the analyzed bacterial strains. Synergistic effects were verified in the association of the fixed oil with gentamicin, ofloxacin and penicillin against multiresistant strains, with reductions in MICs.http://www.sciencedirect.com/science/article/pii/S2772753X24001618MoringaFatty acidsAntibiotic resistanceSynergism |
| spellingShingle | Erlânio Oliveira de Sousa Anielle dos Santos Brito Denise Magalhães Azevedo Feitoza Aureliano de Albuquerque Ribeiro Victória Hellen Nicácio Dias Tavares Mayra Garcia Maia Costa Crisiana de Andrade Nobre Cícera Datiane de Morais Oliveira-Tintino João Arthur de Oliveira Borges Gildênia Alves de Araújo Talysson Felismino Moura João Paulo Martins de Lima Sloana Giesta Lemos Florencio Henrique Douglas Melo Coutinho Irwin Rose Alencar de Menezes Saulo Relison Tintino Chemical analysis of Moringa oleifera (Moringaceae) seed oil and potentiation of antibiotic activity against standard and multidrug-resistant bacterial strains Food Chemistry Advances Moringa Fatty acids Antibiotic resistance Synergism |
| title | Chemical analysis of Moringa oleifera (Moringaceae) seed oil and potentiation of antibiotic activity against standard and multidrug-resistant bacterial strains |
| title_full | Chemical analysis of Moringa oleifera (Moringaceae) seed oil and potentiation of antibiotic activity against standard and multidrug-resistant bacterial strains |
| title_fullStr | Chemical analysis of Moringa oleifera (Moringaceae) seed oil and potentiation of antibiotic activity against standard and multidrug-resistant bacterial strains |
| title_full_unstemmed | Chemical analysis of Moringa oleifera (Moringaceae) seed oil and potentiation of antibiotic activity against standard and multidrug-resistant bacterial strains |
| title_short | Chemical analysis of Moringa oleifera (Moringaceae) seed oil and potentiation of antibiotic activity against standard and multidrug-resistant bacterial strains |
| title_sort | chemical analysis of moringa oleifera moringaceae seed oil and potentiation of antibiotic activity against standard and multidrug resistant bacterial strains |
| topic | Moringa Fatty acids Antibiotic resistance Synergism |
| url | http://www.sciencedirect.com/science/article/pii/S2772753X24001618 |
| work_keys_str_mv | AT erlaniooliveiradesousa chemicalanalysisofmoringaoleiferamoringaceaeseedoilandpotentiationofantibioticactivityagainststandardandmultidrugresistantbacterialstrains AT anielledossantosbrito chemicalanalysisofmoringaoleiferamoringaceaeseedoilandpotentiationofantibioticactivityagainststandardandmultidrugresistantbacterialstrains AT denisemagalhaesazevedofeitoza chemicalanalysisofmoringaoleiferamoringaceaeseedoilandpotentiationofantibioticactivityagainststandardandmultidrugresistantbacterialstrains AT aurelianodealbuquerqueribeiro chemicalanalysisofmoringaoleiferamoringaceaeseedoilandpotentiationofantibioticactivityagainststandardandmultidrugresistantbacterialstrains AT victoriahellennicaciodiastavares chemicalanalysisofmoringaoleiferamoringaceaeseedoilandpotentiationofantibioticactivityagainststandardandmultidrugresistantbacterialstrains AT mayragarciamaiacosta chemicalanalysisofmoringaoleiferamoringaceaeseedoilandpotentiationofantibioticactivityagainststandardandmultidrugresistantbacterialstrains AT crisianadeandradenobre chemicalanalysisofmoringaoleiferamoringaceaeseedoilandpotentiationofantibioticactivityagainststandardandmultidrugresistantbacterialstrains AT ciceradatianedemoraisoliveiratintino chemicalanalysisofmoringaoleiferamoringaceaeseedoilandpotentiationofantibioticactivityagainststandardandmultidrugresistantbacterialstrains AT joaoarthurdeoliveiraborges chemicalanalysisofmoringaoleiferamoringaceaeseedoilandpotentiationofantibioticactivityagainststandardandmultidrugresistantbacterialstrains AT gildeniaalvesdearaujo chemicalanalysisofmoringaoleiferamoringaceaeseedoilandpotentiationofantibioticactivityagainststandardandmultidrugresistantbacterialstrains AT talyssonfelisminomoura chemicalanalysisofmoringaoleiferamoringaceaeseedoilandpotentiationofantibioticactivityagainststandardandmultidrugresistantbacterialstrains AT joaopaulomartinsdelima chemicalanalysisofmoringaoleiferamoringaceaeseedoilandpotentiationofantibioticactivityagainststandardandmultidrugresistantbacterialstrains AT sloanagiestalemosflorencio chemicalanalysisofmoringaoleiferamoringaceaeseedoilandpotentiationofantibioticactivityagainststandardandmultidrugresistantbacterialstrains AT henriquedouglasmelocoutinho chemicalanalysisofmoringaoleiferamoringaceaeseedoilandpotentiationofantibioticactivityagainststandardandmultidrugresistantbacterialstrains AT irwinrosealencardemenezes chemicalanalysisofmoringaoleiferamoringaceaeseedoilandpotentiationofantibioticactivityagainststandardandmultidrugresistantbacterialstrains AT saulorelisontintino chemicalanalysisofmoringaoleiferamoringaceaeseedoilandpotentiationofantibioticactivityagainststandardandmultidrugresistantbacterialstrains |