Antin-diabetic cognitive dysfunction effects and underpinning mechanisms of phytogenic bioactive peptides: a review
Diabetic cognitive dysfunction is one of the important comorbidities and complications of diabetes, which is mainly manifested by loss of learning ability and memory, behavioural disorders, and may even develop into dementia. While traditional anti-diabetic medications are effective in improving cog...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1517087/full |
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| author | Xiaoli Liu Xiaoli Liu Shenglian Mao Shenglian Mao Yuxue Yuan Yuxue Yuan Zilin Wang Zilin Wang Yang Tian Yang Tian Yang Tian Liang Tao Liang Tao Jiahe Dai Jiahe Dai |
| author_facet | Xiaoli Liu Xiaoli Liu Shenglian Mao Shenglian Mao Yuxue Yuan Yuxue Yuan Zilin Wang Zilin Wang Yang Tian Yang Tian Yang Tian Liang Tao Liang Tao Jiahe Dai Jiahe Dai |
| author_sort | Xiaoli Liu |
| collection | DOAJ |
| description | Diabetic cognitive dysfunction is one of the important comorbidities and complications of diabetes, which is mainly manifested by loss of learning ability and memory, behavioural disorders, and may even develop into dementia. While traditional anti-diabetic medications are effective in improving cognition and memory, long-term use of these medications can be accompanied by undesirable side effects. Therefore, there is an urgent need to find safe and effective alternative therapies. Accumulating evidence suggests that phytogenic bioactive peptides play an important role in the regulation of cognitive dysfunction in diabetes. In this review, we explored the relationship between diabetes mellitus and cognitive dysfunction, and the potential and underlying mechanisms of plant-derived bioactive peptides to improve diabetic cognitive dysfunction. We found that plant-derived active peptides alleviate diabetic cognitive impairment by inhibiting key enzymes (e.g., α-glucosidase, α-amylase) to improve blood glucose levels and increase antioxidant activity, modulate inflammatory mediators, and address intestinal dysbiosis. In conclusion, plant-derived active peptides show strong potential to improve diabetic cognitive impairment. |
| format | Article |
| id | doaj-art-aa6cf165856f4ccc97d9bbd0114df521 |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-aa6cf165856f4ccc97d9bbd0114df5212025-01-10T14:22:07ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-01-011110.3389/fnut.2024.15170871517087Antin-diabetic cognitive dysfunction effects and underpinning mechanisms of phytogenic bioactive peptides: a reviewXiaoli Liu0Xiaoli Liu1Shenglian Mao2Shenglian Mao3Yuxue Yuan4Yuxue Yuan5Zilin Wang6Zilin Wang7Yang Tian8Yang Tian9Yang Tian10Liang Tao11Liang Tao12Jiahe Dai13Jiahe Dai14College of Food Science and Technology, Yunan Agricultural University, Kunming, ChinaEngineering Research Center of Development and Utilization of Food and Drug Homologous Resources, Ministry of Education, Yunnan Agricultural University, Kunming, ChinaCollege of Food Science and Technology, Yunan Agricultural University, Kunming, ChinaEngineering Research Center of Development and Utilization of Food and Drug Homologous Resources, Ministry of Education, Yunnan Agricultural University, Kunming, ChinaCollege of Food Science and Technology, Yunan Agricultural University, Kunming, ChinaEngineering Research Center of Development and Utilization of Food and Drug Homologous Resources, Ministry of Education, Yunnan Agricultural University, Kunming, ChinaCollege of Food Science and Technology, Yunan Agricultural University, Kunming, ChinaEngineering Research Center of Development and Utilization of Food and Drug Homologous Resources, Ministry of Education, Yunnan Agricultural University, Kunming, ChinaCollege of Food Science and Technology, Yunan Agricultural University, Kunming, ChinaEngineering Research Center of Development and Utilization of Food and Drug Homologous Resources, Ministry of Education, Yunnan Agricultural University, Kunming, ChinaPu’er College, Pu’er, ChinaCollege of Food Science and Technology, Yunan Agricultural University, Kunming, ChinaEngineering Research Center of Development and Utilization of Food and Drug Homologous Resources, Ministry of Education, Yunnan Agricultural University, Kunming, ChinaCollege of Food Science and Technology, Yunan Agricultural University, Kunming, ChinaEngineering Research Center of Development and Utilization of Food and Drug Homologous Resources, Ministry of Education, Yunnan Agricultural University, Kunming, ChinaDiabetic cognitive dysfunction is one of the important comorbidities and complications of diabetes, which is mainly manifested by loss of learning ability and memory, behavioural disorders, and may even develop into dementia. While traditional anti-diabetic medications are effective in improving cognition and memory, long-term use of these medications can be accompanied by undesirable side effects. Therefore, there is an urgent need to find safe and effective alternative therapies. Accumulating evidence suggests that phytogenic bioactive peptides play an important role in the regulation of cognitive dysfunction in diabetes. In this review, we explored the relationship between diabetes mellitus and cognitive dysfunction, and the potential and underlying mechanisms of plant-derived bioactive peptides to improve diabetic cognitive dysfunction. We found that plant-derived active peptides alleviate diabetic cognitive impairment by inhibiting key enzymes (e.g., α-glucosidase, α-amylase) to improve blood glucose levels and increase antioxidant activity, modulate inflammatory mediators, and address intestinal dysbiosis. In conclusion, plant-derived active peptides show strong potential to improve diabetic cognitive impairment.https://www.frontiersin.org/articles/10.3389/fnut.2024.1517087/fullcognitive improvementcognitive functiondiabetic cognitive dysfunctiondiabetic diseasephytogenic bioactive peptides |
| spellingShingle | Xiaoli Liu Xiaoli Liu Shenglian Mao Shenglian Mao Yuxue Yuan Yuxue Yuan Zilin Wang Zilin Wang Yang Tian Yang Tian Yang Tian Liang Tao Liang Tao Jiahe Dai Jiahe Dai Antin-diabetic cognitive dysfunction effects and underpinning mechanisms of phytogenic bioactive peptides: a review Frontiers in Nutrition cognitive improvement cognitive function diabetic cognitive dysfunction diabetic disease phytogenic bioactive peptides |
| title | Antin-diabetic cognitive dysfunction effects and underpinning mechanisms of phytogenic bioactive peptides: a review |
| title_full | Antin-diabetic cognitive dysfunction effects and underpinning mechanisms of phytogenic bioactive peptides: a review |
| title_fullStr | Antin-diabetic cognitive dysfunction effects and underpinning mechanisms of phytogenic bioactive peptides: a review |
| title_full_unstemmed | Antin-diabetic cognitive dysfunction effects and underpinning mechanisms of phytogenic bioactive peptides: a review |
| title_short | Antin-diabetic cognitive dysfunction effects and underpinning mechanisms of phytogenic bioactive peptides: a review |
| title_sort | antin diabetic cognitive dysfunction effects and underpinning mechanisms of phytogenic bioactive peptides a review |
| topic | cognitive improvement cognitive function diabetic cognitive dysfunction diabetic disease phytogenic bioactive peptides |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1517087/full |
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