Platelet Lysate and Osteoarthritis of the Knee: A Review of Current Clinical Evidence
Abstract Introduction Osteoarthritis (OA) of the knee affects millions of people with sizable socioeconomic burden. Conventional treatment modalities are prioritized, turning to surgical intervention only when they have failed. However, these traditional modalities have shortcomings, only aiming to...
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Adis, Springer Healthcare
2024-09-01
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| Series: | Pain and Therapy |
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| Online Access: | https://doi.org/10.1007/s40122-024-00661-y |
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| author | Ashim Gupta Nicola Maffulli |
| author_facet | Ashim Gupta Nicola Maffulli |
| author_sort | Ashim Gupta |
| collection | DOAJ |
| description | Abstract Introduction Osteoarthritis (OA) of the knee affects millions of people with sizable socioeconomic burden. Conventional treatment modalities are prioritized, turning to surgical intervention only when they have failed. However, these traditional modalities have shortcomings, only aiming to reduce pain rather than targeting the underlying pathophysiology. Recently, the use of biologics, including autologous peripheral blood-derived orthobiologics (APBOs), has increased and demonstrated great promise for the management of knee OA. Platelet-rich plasma (PRP) is the most widely used APBO, but its efficacy is still uncertain, attributed to lack of standardized formulation protocols, characterization, and patient variables. To overcome the limitations posed by PRP, the use of other APBOs such as platelet lysate (PL) has been considered. This review summarizes the outcomes of clinical studies involving PL to manage OA of the knee. Methods Multiple databases (Scopus, Embase, PubMed, and Web of Science) were searched employing terms “platelet lysate” and “knee osteoarthritis” for articles published in the English language to August 15, 2024, adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Results Only three clinical studies fulfilled our search and inclusion criteria. Intra-articular injection of three doses of PL injected every 3–4 weeks is safe and efficacious, resulting in statistically significant improvements in different patient-reported outcome measures at 6–12 months follow-up. Conclusion The existing published peer-reviewed literature suggests that intra-articular injection of PL is safe and can decrease pain and increase function in patients with knee OA. Nonetheless, given the dearth of pertinent literature, more adequately powered, multicenter, prospective, non-randomized and randomized controlled studies with extended follow-up are needed to confirm the effectiveness of PL in knee OA. Further comparative studies to help clinicians in choosing the best APBO for knee OA treatment are also warranted. |
| format | Article |
| id | doaj-art-aa64e516e2fe4db99e3fd0b4c7f28bcc |
| institution | Kabale University |
| issn | 2193-8237 2193-651X |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Pain and Therapy |
| spelling | doaj-art-aa64e516e2fe4db99e3fd0b4c7f28bcc2024-11-10T12:05:42ZengAdis, Springer HealthcarePain and Therapy2193-82372193-651X2024-09-011361377138610.1007/s40122-024-00661-yPlatelet Lysate and Osteoarthritis of the Knee: A Review of Current Clinical EvidenceAshim Gupta0Nicola Maffulli1Future BiologicsDepartment of Trauma and Orthopaedic Surgery, Faculty of Medicine and PsychologyAbstract Introduction Osteoarthritis (OA) of the knee affects millions of people with sizable socioeconomic burden. Conventional treatment modalities are prioritized, turning to surgical intervention only when they have failed. However, these traditional modalities have shortcomings, only aiming to reduce pain rather than targeting the underlying pathophysiology. Recently, the use of biologics, including autologous peripheral blood-derived orthobiologics (APBOs), has increased and demonstrated great promise for the management of knee OA. Platelet-rich plasma (PRP) is the most widely used APBO, but its efficacy is still uncertain, attributed to lack of standardized formulation protocols, characterization, and patient variables. To overcome the limitations posed by PRP, the use of other APBOs such as platelet lysate (PL) has been considered. This review summarizes the outcomes of clinical studies involving PL to manage OA of the knee. Methods Multiple databases (Scopus, Embase, PubMed, and Web of Science) were searched employing terms “platelet lysate” and “knee osteoarthritis” for articles published in the English language to August 15, 2024, adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Results Only three clinical studies fulfilled our search and inclusion criteria. Intra-articular injection of three doses of PL injected every 3–4 weeks is safe and efficacious, resulting in statistically significant improvements in different patient-reported outcome measures at 6–12 months follow-up. Conclusion The existing published peer-reviewed literature suggests that intra-articular injection of PL is safe and can decrease pain and increase function in patients with knee OA. Nonetheless, given the dearth of pertinent literature, more adequately powered, multicenter, prospective, non-randomized and randomized controlled studies with extended follow-up are needed to confirm the effectiveness of PL in knee OA. Further comparative studies to help clinicians in choosing the best APBO for knee OA treatment are also warranted.https://doi.org/10.1007/s40122-024-00661-yKnee osteoarthritisAutologous blood-derived orthobiologicsPlatelet-rich plasmaPlatelet lysatePatient reported outcome measures |
| spellingShingle | Ashim Gupta Nicola Maffulli Platelet Lysate and Osteoarthritis of the Knee: A Review of Current Clinical Evidence Pain and Therapy Knee osteoarthritis Autologous blood-derived orthobiologics Platelet-rich plasma Platelet lysate Patient reported outcome measures |
| title | Platelet Lysate and Osteoarthritis of the Knee: A Review of Current Clinical Evidence |
| title_full | Platelet Lysate and Osteoarthritis of the Knee: A Review of Current Clinical Evidence |
| title_fullStr | Platelet Lysate and Osteoarthritis of the Knee: A Review of Current Clinical Evidence |
| title_full_unstemmed | Platelet Lysate and Osteoarthritis of the Knee: A Review of Current Clinical Evidence |
| title_short | Platelet Lysate and Osteoarthritis of the Knee: A Review of Current Clinical Evidence |
| title_sort | platelet lysate and osteoarthritis of the knee a review of current clinical evidence |
| topic | Knee osteoarthritis Autologous blood-derived orthobiologics Platelet-rich plasma Platelet lysate Patient reported outcome measures |
| url | https://doi.org/10.1007/s40122-024-00661-y |
| work_keys_str_mv | AT ashimgupta plateletlysateandosteoarthritisofthekneeareviewofcurrentclinicalevidence AT nicolamaffulli plateletlysateandosteoarthritisofthekneeareviewofcurrentclinicalevidence |