Carbonic Anhydrase IX Enzyme in Triple Negative Breast Carcinoma: Relationship With Prognostic Factors and Response to Neoadjuvant Chemotherapy
Objective: Triple negative breast carcinoma (TNBC) is characterized by the absence of estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2 receptor expression. Carbonic anhydrase IX (CA IX) is a tumor-associated cell surface glycoprotein that is involved in adaptatio...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2025-01-01
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| Series: | European Journal of Breast Health |
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| Online Access: | https://www.eurjbreasthealth.com/articles/carbonic-anhydrase-ix-enzyme-in-triple-negative-breast-carcinoma-relationship-with-prognostic-factors-and-response-to-neoadjuvant-chemotherapy/doi/ejbh.galenos.2024.2024-6-1 |
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| author | Özgen Arslan Solmaz Nizamettin Kutluer Mehmet Buğra Bozan |
| author_facet | Özgen Arslan Solmaz Nizamettin Kutluer Mehmet Buğra Bozan |
| author_sort | Özgen Arslan Solmaz |
| collection | DOAJ |
| description | Objective: Triple negative breast carcinoma (TNBC) is characterized by the absence of estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2 receptor expression. Carbonic anhydrase IX (CA IX) is a tumor-associated cell surface glycoprotein that is involved in adaptation to hypoxia-induced acidosis and plays a role in cancer progression. The aim of this study was to investigate CA IX expression in TNBC and its relationship with treatment effect.
Materials and Methods: Immunohistochemical staining was performed on tru-cut biopsy materials with CA IX antibody. Positive staining was graded as low (<10%) and high (>10%). In addition, the relationship between tumor diameter, histological grade and the treatment effect on mastectomy materials performed after neoadjuvant treatment was evaluated.
Results: TNBCs with positive staining for CA IX exhibited higher histological grade, and higher Ki-67 index compared to TNBCs with negative staining (p < 0.05). The response to treatment decreased as the degree of CA IX staining increased. There was no significant difference between the high staining group and low staining group in terms of patient age, tumor diameter and breast localisation.
Conclusion: CA IX enzyme is a poor prognostic marker in TNBC cases. However, overexpression of CA IX was associated with reduced response to treatment. |
| format | Article |
| id | doaj-art-aa20cde065464724bf1790de389a9f65 |
| institution | Kabale University |
| issn | 2587-0831 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | European Journal of Breast Health |
| spelling | doaj-art-aa20cde065464724bf1790de389a9f652025-01-07T11:00:12ZengGalenos Publishing HouseEuropean Journal of Breast Health2587-08312025-01-01211576210.4274/ejbh.galenos.2024.2024-6-1Carbonic Anhydrase IX Enzyme in Triple Negative Breast Carcinoma: Relationship With Prognostic Factors and Response to Neoadjuvant ChemotherapyÖzgen Arslan Solmaz0https://orcid.org/0000-0002-8942-199XNizamettin Kutluer1https://orcid.org/0000-0002-8737-7462Mehmet Buğra Bozan2https://orcid.org/0000-0001-5573-2645Department of Pathology, Elazığ Fethi Sekin City Hospital, University of Health Sciences Turkey, Elazığ, TurkeyDepartment of General Surgery, Elazığ Fethi Sekin City Hospital, University of Health Sciences Turkey, Elazığ, TurkeyDepartment of General Surgery, Elazığ Fethi Sekin City Hospital, University of Health Sciences Turkey, Elazığ, TurkeyObjective: Triple negative breast carcinoma (TNBC) is characterized by the absence of estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2 receptor expression. Carbonic anhydrase IX (CA IX) is a tumor-associated cell surface glycoprotein that is involved in adaptation to hypoxia-induced acidosis and plays a role in cancer progression. The aim of this study was to investigate CA IX expression in TNBC and its relationship with treatment effect. Materials and Methods: Immunohistochemical staining was performed on tru-cut biopsy materials with CA IX antibody. Positive staining was graded as low (<10%) and high (>10%). In addition, the relationship between tumor diameter, histological grade and the treatment effect on mastectomy materials performed after neoadjuvant treatment was evaluated. Results: TNBCs with positive staining for CA IX exhibited higher histological grade, and higher Ki-67 index compared to TNBCs with negative staining (p < 0.05). The response to treatment decreased as the degree of CA IX staining increased. There was no significant difference between the high staining group and low staining group in terms of patient age, tumor diameter and breast localisation. Conclusion: CA IX enzyme is a poor prognostic marker in TNBC cases. However, overexpression of CA IX was associated with reduced response to treatment.https://www.eurjbreasthealth.com/articles/carbonic-anhydrase-ix-enzyme-in-triple-negative-breast-carcinoma-relationship-with-prognostic-factors-and-response-to-neoadjuvant-chemotherapy/doi/ejbh.galenos.2024.2024-6-1triple negative breast carcinomacarbonic anhydrase ixtreatment effectki-67 proliferation index |
| spellingShingle | Özgen Arslan Solmaz Nizamettin Kutluer Mehmet Buğra Bozan Carbonic Anhydrase IX Enzyme in Triple Negative Breast Carcinoma: Relationship With Prognostic Factors and Response to Neoadjuvant Chemotherapy European Journal of Breast Health triple negative breast carcinoma carbonic anhydrase ix treatment effect ki-67 proliferation index |
| title | Carbonic Anhydrase IX Enzyme in Triple Negative Breast Carcinoma: Relationship With Prognostic Factors and Response to Neoadjuvant Chemotherapy |
| title_full | Carbonic Anhydrase IX Enzyme in Triple Negative Breast Carcinoma: Relationship With Prognostic Factors and Response to Neoadjuvant Chemotherapy |
| title_fullStr | Carbonic Anhydrase IX Enzyme in Triple Negative Breast Carcinoma: Relationship With Prognostic Factors and Response to Neoadjuvant Chemotherapy |
| title_full_unstemmed | Carbonic Anhydrase IX Enzyme in Triple Negative Breast Carcinoma: Relationship With Prognostic Factors and Response to Neoadjuvant Chemotherapy |
| title_short | Carbonic Anhydrase IX Enzyme in Triple Negative Breast Carcinoma: Relationship With Prognostic Factors and Response to Neoadjuvant Chemotherapy |
| title_sort | carbonic anhydrase ix enzyme in triple negative breast carcinoma relationship with prognostic factors and response to neoadjuvant chemotherapy |
| topic | triple negative breast carcinoma carbonic anhydrase ix treatment effect ki-67 proliferation index |
| url | https://www.eurjbreasthealth.com/articles/carbonic-anhydrase-ix-enzyme-in-triple-negative-breast-carcinoma-relationship-with-prognostic-factors-and-response-to-neoadjuvant-chemotherapy/doi/ejbh.galenos.2024.2024-6-1 |
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