MRI imaging characteristics of brainstem and midbrain aqueduct in patients with iNPH
Abstract Idiopathic normal pressure hydrocephalus (iNPH) is frequently difficult to diagnose due to the absence of specific symptoms, yet early detection and surgical intervention are essential for preventing sequela such as irreversible dementia. This study explores the specific magnetic resonance...
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-83874-7 |
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| author | Kui Xiao Liangxue Zhou Xielin Tang Shenghua Liu Ziang Deng Feilong Yang |
| author_facet | Kui Xiao Liangxue Zhou Xielin Tang Shenghua Liu Ziang Deng Feilong Yang |
| author_sort | Kui Xiao |
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| description | Abstract Idiopathic normal pressure hydrocephalus (iNPH) is frequently difficult to diagnose due to the absence of specific symptoms, yet early detection and surgical intervention are essential for preventing sequela such as irreversible dementia. This study explores the specific magnetic resonance imaging (MRI) features of the brainstem and mesencephalic aqueduct in patients with iNPH. Head MRI data of 50 iNPH patients and 30 healthy matched controls were compared for mesencephalic aqueduct length, diameter, and angle, structural features of the brainstem at the sagittal plane, brainstem component volume ratios, angle between the brainstem and spinal cord, and the area and morphology of the pontine cisterns. Compared to healthy individuals, iNPH patients exhibited significant dilation of the mesencephalic aqueduct diameter, a reduced aqueduct angle, and a decrease in the sagittal plane area of the brainstem, with the most pronounced reduction in the midbrain region. Notably, the CSF spaces surrounding the brainstem were dilated, resulting in the prepontine cistern presenting a “hammer-like” shape on the sagittal plane. The prevalence of this hammer shape was positively correlated with prepontine cistern area in patients with iNPH. These unique imaging characteristics may facilitate the clinical recognition of iNPH for early diagnosis and treatment. |
| format | Article |
| id | doaj-art-aa1f0ef75ecb47949aae7f4c607469e6 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-aa1f0ef75ecb47949aae7f4c607469e62025-01-05T12:14:20ZengNature PortfolioScientific Reports2045-23222025-01-0115111410.1038/s41598-024-83874-7MRI imaging characteristics of brainstem and midbrain aqueduct in patients with iNPHKui Xiao0Liangxue Zhou1Xielin Tang2Shenghua Liu3Ziang Deng4Feilong Yang5Department of Neurosurgery, West China Hospital of Sichuan UniversityDepartment of Neurosurgery, West China Hospital of Sichuan UniversityDepartment of Neurosurgery, West China Hospital of Sichuan UniversityDepartment of Neurosurgery, Santai People’s HospitalDepartment of Neurosurgery, West China Hospital of Sichuan UniversityDepartment of Neurosurgery, Santai People’s HospitalAbstract Idiopathic normal pressure hydrocephalus (iNPH) is frequently difficult to diagnose due to the absence of specific symptoms, yet early detection and surgical intervention are essential for preventing sequela such as irreversible dementia. This study explores the specific magnetic resonance imaging (MRI) features of the brainstem and mesencephalic aqueduct in patients with iNPH. Head MRI data of 50 iNPH patients and 30 healthy matched controls were compared for mesencephalic aqueduct length, diameter, and angle, structural features of the brainstem at the sagittal plane, brainstem component volume ratios, angle between the brainstem and spinal cord, and the area and morphology of the pontine cisterns. Compared to healthy individuals, iNPH patients exhibited significant dilation of the mesencephalic aqueduct diameter, a reduced aqueduct angle, and a decrease in the sagittal plane area of the brainstem, with the most pronounced reduction in the midbrain region. Notably, the CSF spaces surrounding the brainstem were dilated, resulting in the prepontine cistern presenting a “hammer-like” shape on the sagittal plane. The prevalence of this hammer shape was positively correlated with prepontine cistern area in patients with iNPH. These unique imaging characteristics may facilitate the clinical recognition of iNPH for early diagnosis and treatment.https://doi.org/10.1038/s41598-024-83874-7Idiopathic normal pressure hydrocephalusCharacteristic imaging indicatorsMesencephalic aqueductBrainstem volume ratioPrepontine cistern“Hammer” shape. |
| spellingShingle | Kui Xiao Liangxue Zhou Xielin Tang Shenghua Liu Ziang Deng Feilong Yang MRI imaging characteristics of brainstem and midbrain aqueduct in patients with iNPH Scientific Reports Idiopathic normal pressure hydrocephalus Characteristic imaging indicators Mesencephalic aqueduct Brainstem volume ratio Prepontine cistern “Hammer” shape. |
| title | MRI imaging characteristics of brainstem and midbrain aqueduct in patients with iNPH |
| title_full | MRI imaging characteristics of brainstem and midbrain aqueduct in patients with iNPH |
| title_fullStr | MRI imaging characteristics of brainstem and midbrain aqueduct in patients with iNPH |
| title_full_unstemmed | MRI imaging characteristics of brainstem and midbrain aqueduct in patients with iNPH |
| title_short | MRI imaging characteristics of brainstem and midbrain aqueduct in patients with iNPH |
| title_sort | mri imaging characteristics of brainstem and midbrain aqueduct in patients with inph |
| topic | Idiopathic normal pressure hydrocephalus Characteristic imaging indicators Mesencephalic aqueduct Brainstem volume ratio Prepontine cistern “Hammer” shape. |
| url | https://doi.org/10.1038/s41598-024-83874-7 |
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