Measuring fluid balance in end-stage renal disease with a wearable bioimpedance sensor
Abstract Background Accurate assessment of fluid volume and hydration status is essential in many disease states, including patients with chronic kidney disease. The aim of this study was to investigate the ability of a wearable continuous bioimpedance sensor to detect changes in fluid volume in pat...
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BMC
2025-01-01
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| Series: | BMC Nephrology |
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| Online Access: | https://doi.org/10.1186/s12882-024-03929-9 |
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| author | Frida Bremnes Cecilia Montgomery Øien Jørn Kvaerness Ellen Andreassen Jaatun Sigve Nyvik Aas Terje Saether Henrik Lund Solfrid Romundstad |
| author_facet | Frida Bremnes Cecilia Montgomery Øien Jørn Kvaerness Ellen Andreassen Jaatun Sigve Nyvik Aas Terje Saether Henrik Lund Solfrid Romundstad |
| author_sort | Frida Bremnes |
| collection | DOAJ |
| description | Abstract Background Accurate assessment of fluid volume and hydration status is essential in many disease states, including patients with chronic kidney disease. The aim of this study was to investigate the ability of a wearable continuous bioimpedance sensor to detect changes in fluid volume in patients undergoing regular hemodialysis (HD). Methods 31 patients with end-stage renal disease were enrolled and monitored with a sensor patch (Re:Balans®) on the upper back through two consecutive HD sessions and the interdialytic period between. The extracellular resistance RE was calculated from multi-frequency bioimpedance measurements and was hypothesized to correlate with the amount of extracted fluid during dialysis. Results Only HD sessions with a positive net fluid extraction were included in the primary analysis. Participants had an increase of 7.5 ± 4.3 Ω (Ohm) in RE during the first HD and 6.2 ± 2.3 Ω during the second HD, and a fluid extraction (ultrafiltration (UF) volume) of 1.5 ± 0.8 L and 1.2 ± 0.6 L, respectively. The relative change in RE during HD correlated strongly with UF volume (r = 0.82, p < 0.001). During the interdialytic period, the patients had a mean decrease in RE of 6.0 ± 3.5 Ω. Longitudinal changes in RE (%) and body weight (kg) over the entire study period was negatively correlated (r = -0.61 p < 0.001). Longitudinal changes in blood samples and cardiovascular changes were also in agreement with changes in weight and RE. Conclusions The results of this clinical investigation indicate that the investigational device is capable of tracking both rapid and gradual changes in hydration status in patients undergoing regular HD. |
| format | Article |
| id | doaj-art-aa16de44100444a99aab553fbe291d5f |
| institution | Kabale University |
| issn | 1471-2369 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj-art-aa16de44100444a99aab553fbe291d5f2025-01-12T12:11:32ZengBMCBMC Nephrology1471-23692025-01-0126111010.1186/s12882-024-03929-9Measuring fluid balance in end-stage renal disease with a wearable bioimpedance sensorFrida Bremnes0Cecilia Montgomery Øien1Jørn Kvaerness2Ellen Andreassen Jaatun3Sigve Nyvik Aas4Terje Saether5Henrik Lund6Solfrid Romundstad7Mode Sensors ASDepartment of Nephrology, St. Olavs HospitalMode Sensors ASMode Sensors ASMode Sensors ASMode Sensors ASMode Sensors ASDepartment of Internal Medicine, Levanger Hospital, Nord-Trøndelag Health TrustAbstract Background Accurate assessment of fluid volume and hydration status is essential in many disease states, including patients with chronic kidney disease. The aim of this study was to investigate the ability of a wearable continuous bioimpedance sensor to detect changes in fluid volume in patients undergoing regular hemodialysis (HD). Methods 31 patients with end-stage renal disease were enrolled and monitored with a sensor patch (Re:Balans®) on the upper back through two consecutive HD sessions and the interdialytic period between. The extracellular resistance RE was calculated from multi-frequency bioimpedance measurements and was hypothesized to correlate with the amount of extracted fluid during dialysis. Results Only HD sessions with a positive net fluid extraction were included in the primary analysis. Participants had an increase of 7.5 ± 4.3 Ω (Ohm) in RE during the first HD and 6.2 ± 2.3 Ω during the second HD, and a fluid extraction (ultrafiltration (UF) volume) of 1.5 ± 0.8 L and 1.2 ± 0.6 L, respectively. The relative change in RE during HD correlated strongly with UF volume (r = 0.82, p < 0.001). During the interdialytic period, the patients had a mean decrease in RE of 6.0 ± 3.5 Ω. Longitudinal changes in RE (%) and body weight (kg) over the entire study period was negatively correlated (r = -0.61 p < 0.001). Longitudinal changes in blood samples and cardiovascular changes were also in agreement with changes in weight and RE. Conclusions The results of this clinical investigation indicate that the investigational device is capable of tracking both rapid and gradual changes in hydration status in patients undergoing regular HD.https://doi.org/10.1186/s12882-024-03929-9BioimpedanceHydrationKidney failure |
| spellingShingle | Frida Bremnes Cecilia Montgomery Øien Jørn Kvaerness Ellen Andreassen Jaatun Sigve Nyvik Aas Terje Saether Henrik Lund Solfrid Romundstad Measuring fluid balance in end-stage renal disease with a wearable bioimpedance sensor BMC Nephrology Bioimpedance Hydration Kidney failure |
| title | Measuring fluid balance in end-stage renal disease with a wearable bioimpedance sensor |
| title_full | Measuring fluid balance in end-stage renal disease with a wearable bioimpedance sensor |
| title_fullStr | Measuring fluid balance in end-stage renal disease with a wearable bioimpedance sensor |
| title_full_unstemmed | Measuring fluid balance in end-stage renal disease with a wearable bioimpedance sensor |
| title_short | Measuring fluid balance in end-stage renal disease with a wearable bioimpedance sensor |
| title_sort | measuring fluid balance in end stage renal disease with a wearable bioimpedance sensor |
| topic | Bioimpedance Hydration Kidney failure |
| url | https://doi.org/10.1186/s12882-024-03929-9 |
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