Potential of medicinal plants to ameliorate neovascularization activities in diabetes: A systematic review
Hyperglycemia in diabetes mediates the release of angiogenic factors, oxidative stress, hypoxia, and inflammation, which in turn stimulate angiogenesis. Excessive angiogenesis can cause diabetic retinopathy, diabetic neuropathy, and diabetic nephropathy. All of these complications are debilitating,...
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| Format: | Article |
| Language: | English |
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Sciendo
2024-01-01
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| Series: | Endocrine Regulations |
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| Online Access: | https://doi.org/10.2478/enr-2024-0004 |
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| author | Yong Phaik Har New Shin Yee Azzani Meram Wu Yuan Seng Chia Vi Vien Ng Zhi Xiang |
| author_facet | Yong Phaik Har New Shin Yee Azzani Meram Wu Yuan Seng Chia Vi Vien Ng Zhi Xiang |
| author_sort | Yong Phaik Har |
| collection | DOAJ |
| description | Hyperglycemia in diabetes mediates the release of angiogenic factors, oxidative stress, hypoxia, and inflammation, which in turn stimulate angiogenesis. Excessive angiogenesis can cause diabetic retinopathy, diabetic neuropathy, and diabetic nephropathy. All of these complications are debilitating, which may lead to an increased susceptibility to lower-limb amputations due to ulcerations and infections. In addition, microvascular alterations, segmental demyelination, and endoneurial microangiopathy may cause progressive deterioration ultimately leading to kidney failure and permanent blindness. Some medicinal plants have potent anti-angiogenic, antioxidant or anti-inflammatory properties that can ameliorate angiogenesis in diabetes. The purpose of this systematic review is to demonstrate the potential of medicinal plants in ameliorating the neovascularization activities in diabetes. Manuscripts were searched from PubMed, Science Direct, and Scopus databases, and Google Scholar was used for searching additional papers. From 1862 manuscripts searched, 1854 were excluded based on inclusion and exclusion criteria and 8 were included into this systematic review, whereas the required information was extracted and summarized. All identified medicinal plants decreased the high blood glucose levels in diabetes, except the aqueous extract of Lonicerae japonicae flos (FJL) and Vasant Kusumakar Ras. They also increased the reduced body weight in diabetes, except the aqueous extract of FL and total lignans from Fructus arctii. However, methanolic extract of Tinospora cordifolia and Vasant Kusumakar Ras were not tested for their ability to affect the body weight. Besides, all medicinal plants identified in this systematic review decreased the vascular endothelial growth factor (VEGF) protein expression and vasculature activity demonstrated by histopathological examination indicating promising anti-angiogenic properties. All medicinal plants identified in this systematic review have a potential to ameliorate neovascularization activities in diabetes by targeting the mechanistic pathways related to oxidative stress, inflammation, and angiogenesis. |
| format | Article |
| id | doaj-art-a9f750709243467fbe2ffe3f8e7c5cb6 |
| institution | Kabale University |
| issn | 1336-0329 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Endocrine Regulations |
| spelling | doaj-art-a9f750709243467fbe2ffe3f8e7c5cb62024-11-25T11:20:07ZengSciendoEndocrine Regulations1336-03292024-01-01581263910.2478/enr-2024-0004Potential of medicinal plants to ameliorate neovascularization activities in diabetes: A systematic reviewYong Phaik Har0New Shin Yee1Azzani Meram2Wu Yuan Seng3Chia Vi Vien4Ng Zhi Xiang5School of Bioscience, Faculty of Pharmacy & Biomedical Sciences, MAHSA University, Selangor, MalaysiaSchool of Bioscience, Faculty of Pharmacy & Biomedical Sciences, MAHSA University, Selangor, MalaysiaDepartment of Public Health Medicine, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, 47000, Sungai Buloh, Selangor, Malaysiaand Centre of Occupational Safety, Health and Wellbeing, Universiti Teknologi MARA, , MalaysiaSunway Microbiome Centre, School of Medical and Life Sciences, Sunway University, Subang Jaya 47500, Selangor, MalaysiaSchool of Bioscience, Faculty of Pharmacy & Biomedical Sciences, MAHSA University, Selangor, MalaysiaSchool of Biosciences, Faculty of Science and Engineering, University of Nottingham Malaysia, Selangor, MalaysiaHyperglycemia in diabetes mediates the release of angiogenic factors, oxidative stress, hypoxia, and inflammation, which in turn stimulate angiogenesis. Excessive angiogenesis can cause diabetic retinopathy, diabetic neuropathy, and diabetic nephropathy. All of these complications are debilitating, which may lead to an increased susceptibility to lower-limb amputations due to ulcerations and infections. In addition, microvascular alterations, segmental demyelination, and endoneurial microangiopathy may cause progressive deterioration ultimately leading to kidney failure and permanent blindness. Some medicinal plants have potent anti-angiogenic, antioxidant or anti-inflammatory properties that can ameliorate angiogenesis in diabetes. The purpose of this systematic review is to demonstrate the potential of medicinal plants in ameliorating the neovascularization activities in diabetes. Manuscripts were searched from PubMed, Science Direct, and Scopus databases, and Google Scholar was used for searching additional papers. From 1862 manuscripts searched, 1854 were excluded based on inclusion and exclusion criteria and 8 were included into this systematic review, whereas the required information was extracted and summarized. All identified medicinal plants decreased the high blood glucose levels in diabetes, except the aqueous extract of Lonicerae japonicae flos (FJL) and Vasant Kusumakar Ras. They also increased the reduced body weight in diabetes, except the aqueous extract of FL and total lignans from Fructus arctii. However, methanolic extract of Tinospora cordifolia and Vasant Kusumakar Ras were not tested for their ability to affect the body weight. Besides, all medicinal plants identified in this systematic review decreased the vascular endothelial growth factor (VEGF) protein expression and vasculature activity demonstrated by histopathological examination indicating promising anti-angiogenic properties. All medicinal plants identified in this systematic review have a potential to ameliorate neovascularization activities in diabetes by targeting the mechanistic pathways related to oxidative stress, inflammation, and angiogenesis.https://doi.org/10.2478/enr-2024-0004medicinal plantsneovascularizationdiabetessystematic review |
| spellingShingle | Yong Phaik Har New Shin Yee Azzani Meram Wu Yuan Seng Chia Vi Vien Ng Zhi Xiang Potential of medicinal plants to ameliorate neovascularization activities in diabetes: A systematic review Endocrine Regulations medicinal plants neovascularization diabetes systematic review |
| title | Potential of medicinal plants to ameliorate neovascularization activities in diabetes: A systematic review |
| title_full | Potential of medicinal plants to ameliorate neovascularization activities in diabetes: A systematic review |
| title_fullStr | Potential of medicinal plants to ameliorate neovascularization activities in diabetes: A systematic review |
| title_full_unstemmed | Potential of medicinal plants to ameliorate neovascularization activities in diabetes: A systematic review |
| title_short | Potential of medicinal plants to ameliorate neovascularization activities in diabetes: A systematic review |
| title_sort | potential of medicinal plants to ameliorate neovascularization activities in diabetes a systematic review |
| topic | medicinal plants neovascularization diabetes systematic review |
| url | https://doi.org/10.2478/enr-2024-0004 |
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