Harnessing the power of traceable system C-GAP: homologous-targeting to fire up T-cell immune responses with low-dose irradiation

Harnessing the power of traceable system C-GAP: homologous-targeting to fire up T-cell immune responses with low-dose irradiation

Abstract While radiotherapy-induced immunogenic cell death (ICD) holds potential for enhancing cancer immunotherapy, the conventional high-dose irradiation often leads to an immunosuppressive microenvironment and systemic toxicity. Therefore, a biomimetic nanoplatform cell membrane coated-nitrogen-d...

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Bibliographic Details
Main Authors: Weijie Zhuang, Kuangwu Pan, Jie Wu, Leyi Liu, Shiyu Lv, Jiajun Hu, Fangyang Shi, Wei Zhao, Dongsheng Yu
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Nanobiotechnology
Subjects:
Biomimetic nanoparticle
Radioimmunotherapy
Immunogenic cell death (ICD)
Homologous targeting
Oral squamous cell carcinoma (OSCC)
Online Access:https://doi.org/10.1186/s12951-025-03281-6
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https://doi.org/10.1186/s12951-025-03281-6

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