Associations of serum and tissue TIMP1 with host response and survival in colorectal cancer

Associations of serum and tissue TIMP1 with host response and survival in colorectal cancer

Abstract Tissue inhibitor of matrix metalloproteinase 1 (TIMP1) is a multifaceted, cytokine-like bioactive molecule whose levels are elevated in a wide range of inflammatory diseases and are associated with prognosis. Additionally, TIMP1 may play a role in driving systemic inflammation. TIMP1 immuno...

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Main Authors: Akseli Kehusmaa, Anne Tuomisto, Päivi Sirniö, Henna Karjalainen, Meeri Kastinen, Vilja V. Tapiainen, Ville K. Äijälä, Taina Tervahartiala, Timo Sorsa, Jukka Rintala, Sanna Meriläinen, Juha Saarnio, Tero Rautio, Markus J. Mäkinen, Juha P. Väyrynen
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Colorectal cancer
TIMP1
Prognosis
Immunohistochemistry
Serum biomarker
Online Access:https://doi.org/10.1038/s41598-025-85549-3
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