Staphylococcus epidermidis alters macrophage polarization and phagocytic uptake by extracellular DNA release in vitro

Staphylococcus epidermidis alters macrophage polarization and phagocytic uptake by extracellular DNA release in vitro

Abstract Biofilm formation shields Staphylococcus epidermidis from host defense mechanisms, contributing to chronic implant infections. Using wild-type S. epidermidis 1457, a PIA-negative mutant (1457-M10), and an eDNA-negative mutant (1457ΔatlE), this study examined the influence of biofilm matrix...

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Bibliographic Details
Main Authors: Samira Weißelberg, Anna Both, Antonio Virgilio Failla, Jiabin Huang, Stefan Linder, Denise Ohnezeit, Patricia Bartsch, Martin Aepfelbacher, Holger Rohde
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:npj Biofilms and Microbiomes
Online Access:https://doi.org/10.1038/s41522-024-00604-7
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