Sodium formate-induced mitochondrial impairment and cytotoxicity in neuronal cells reveal crucial pathogenic mechanisms underlying diabetic neuropathy and retinopathy
Abstract Formic acid, a toxic one-carbon metabolite formed from methanol and formaldehyde in the body, can cause neuronal dysfunctions. It was recently hypothesized that metabolic formation of toxic one-carbon metabolites (particularly formic acid) under hyperglycemic conditions may contribute to th...
Saved in:
| Main Authors: | Tian Hao Xiao, Bao Ting Zhu |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-11312-3 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Jujuboside A improves insomnia by maintaining mitochondrial homeostasis in prefrontal neurons
by: Zhen Zhang, et al.
Published: (2025-06-01) -
ATP Synthase Abundance in Neuronal Extracellular Vesicles Reflects Changes in the Mitochondria of Parent Neurons
by: Pamela J. Yao, et al.
Published: (2025-08-01) -
Mitochondrial Complex V (ATP-synthase) Deficiency Nuclear Type 2, Caused by Mutation in the TMEM70 Gene: the First Case in Russia
by: Natal’ya V. Zhurkova, et al.
Published: (2018-05-01) -
Mitochondria power the nucleus under pressure
by: Meng Yao, et al.
Published: (2025-09-01) -
Yttrium oxide nanoparticles induce selective cytotoxicity, genomic instability and ROS mitochondrial P53 mediated apoptosis in human pancreatic cancer cells
by: Hanan R. H. Mohamed, et al.
Published: (2025-06-01)