Atg5 deficiency in basophils improves metabolism in lupus mice by regulating gut microbiota dysbiosis

Atg5 deficiency in basophils improves metabolism in lupus mice by regulating gut microbiota dysbiosis

Abstract Autophagic activation in immune cells, gut microbiota dysbiosis, and metabolic abnormalities have been reported separately as characteristics of systemic lupus erythematosus (SLE). Elucidating the crosstalk among the immune system, commensal microbiota, and metabolites is crucial to underst...

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Bibliographic Details
Main Authors: Jiaxuan Chen, Quanren Pan, Lu Lu, Xiaorong Huang, Shuting Wang, Xiaoxian Liu, Jiaqi Lun, Xiaowei Xu, Hongyong Su, Fengbiao Guo, Lawei Yang, Liuyong You, Haiyan Xiao, Wenying Luo, Hua-feng Liu, Qingjun Pan
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Cell Communication and Signaling
Subjects:
Basophils
Atg5
Lupus
Gut microbiota
Metabolism
Autoantibodies
Online Access:https://doi.org/10.1186/s12964-025-02041-1
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