Predictive value of inflammatory indexes in in-hospital mortality for patients with acute aortic dissection
Abstract Background The purpose of this study was to assess the relationship between admission inflammatory indexes neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and systemic immune-inflammation index (SII), and the risk of in-hospital all-cause mortality in acute aortic...
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BMC
2025-04-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-025-04775-9 |
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| author | Yijing Xin Siqi Lyu Jingyang Wang Yimeng Wang Yuyuan Shu Hanyang Liang Yanmin Yang |
| author_facet | Yijing Xin Siqi Lyu Jingyang Wang Yimeng Wang Yuyuan Shu Hanyang Liang Yanmin Yang |
| author_sort | Yijing Xin |
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| description | Abstract Background The purpose of this study was to assess the relationship between admission inflammatory indexes neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and systemic immune-inflammation index (SII), and the risk of in-hospital all-cause mortality in acute aortic dissection (AAD) patients. Methods A retrospective analysis was conducted on 597 AAD patients (Stanford classification: Stanford type A 365 patients, Stanford type B 232 patients) at a single center. Outcomes were the incidence of in-hospital all-cause mortality. The risk of all-cause death was compared between the groups with low and high inflammatory indexes using the Kaplan-Meier curve. The association between admission inflammatory indexes and outcomes was evaluated using the Cox regression model and restricted cubic splines (RCS). Stratified analysis was performed based on AAD type, age (< 50 years or ≥ 50 years), and gender. Results The Kaplan-Meier curves revealed statistically significant differences in outcomes among the low and high inflammatory indexes groups. Cox regression analysis revealed that the in-hospital mortality risk was significantly high in the high inflammatory index groups. MLR was the strongest associated with in-hospital mortality risk. The RCS curve revealed that NLR was non-linearly and J-shaped correlated with in-hospital mortality, and MLR and SII were linearly correlated with in-hospital mortality. Stratified analysis showed interactions between NLR, MLR, and SII and AAD type and age for the risk of in-hospital mortality. Conclusion Admission high inflammatory indexes were independently associated with an increased risk of in-hospital all-cause mortality in AAD patients. The inflammatory indexes NLR, MLR, and SII may be useful indicators for predicting in-hospital all-cause mortality in AAD patients. |
| format | Article |
| id | doaj-art-a96f07928e4e4acb8fbd7cde7ac38f89 |
| institution | DOAJ |
| issn | 1471-2261 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-a96f07928e4e4acb8fbd7cde7ac38f892025-08-20T03:14:05ZengBMCBMC Cardiovascular Disorders1471-22612025-04-012511810.1186/s12872-025-04775-9Predictive value of inflammatory indexes in in-hospital mortality for patients with acute aortic dissectionYijing Xin0Siqi Lyu1Jingyang Wang2Yimeng Wang3Yuyuan Shu4Hanyang Liang5Yanmin Yang6Emergency Center, State Key Laboratory of Cardiovascular Disease of China, National Center for Cardiovascular Diseases, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeEmergency Center, State Key Laboratory of Cardiovascular Disease of China, National Center for Cardiovascular Diseases, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeEmergency Center, State Key Laboratory of Cardiovascular Disease of China, National Center for Cardiovascular Diseases, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeEmergency Center, State Key Laboratory of Cardiovascular Disease of China, National Center for Cardiovascular Diseases, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeEmergency Center, State Key Laboratory of Cardiovascular Disease of China, National Center for Cardiovascular Diseases, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeEmergency Center, State Key Laboratory of Cardiovascular Disease of China, National Center for Cardiovascular Diseases, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeEmergency Center, State Key Laboratory of Cardiovascular Disease of China, National Center for Cardiovascular Diseases, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeAbstract Background The purpose of this study was to assess the relationship between admission inflammatory indexes neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and systemic immune-inflammation index (SII), and the risk of in-hospital all-cause mortality in acute aortic dissection (AAD) patients. Methods A retrospective analysis was conducted on 597 AAD patients (Stanford classification: Stanford type A 365 patients, Stanford type B 232 patients) at a single center. Outcomes were the incidence of in-hospital all-cause mortality. The risk of all-cause death was compared between the groups with low and high inflammatory indexes using the Kaplan-Meier curve. The association between admission inflammatory indexes and outcomes was evaluated using the Cox regression model and restricted cubic splines (RCS). Stratified analysis was performed based on AAD type, age (< 50 years or ≥ 50 years), and gender. Results The Kaplan-Meier curves revealed statistically significant differences in outcomes among the low and high inflammatory indexes groups. Cox regression analysis revealed that the in-hospital mortality risk was significantly high in the high inflammatory index groups. MLR was the strongest associated with in-hospital mortality risk. The RCS curve revealed that NLR was non-linearly and J-shaped correlated with in-hospital mortality, and MLR and SII were linearly correlated with in-hospital mortality. Stratified analysis showed interactions between NLR, MLR, and SII and AAD type and age for the risk of in-hospital mortality. Conclusion Admission high inflammatory indexes were independently associated with an increased risk of in-hospital all-cause mortality in AAD patients. The inflammatory indexes NLR, MLR, and SII may be useful indicators for predicting in-hospital all-cause mortality in AAD patients.https://doi.org/10.1186/s12872-025-04775-9Acute aortic dissectionInflammatory indexesNeutrophil-to-lymphocyte ratioMonocyte-to-lymphocyte ratioSystemic immune-inflammation index |
| spellingShingle | Yijing Xin Siqi Lyu Jingyang Wang Yimeng Wang Yuyuan Shu Hanyang Liang Yanmin Yang Predictive value of inflammatory indexes in in-hospital mortality for patients with acute aortic dissection BMC Cardiovascular Disorders Acute aortic dissection Inflammatory indexes Neutrophil-to-lymphocyte ratio Monocyte-to-lymphocyte ratio Systemic immune-inflammation index |
| title | Predictive value of inflammatory indexes in in-hospital mortality for patients with acute aortic dissection |
| title_full | Predictive value of inflammatory indexes in in-hospital mortality for patients with acute aortic dissection |
| title_fullStr | Predictive value of inflammatory indexes in in-hospital mortality for patients with acute aortic dissection |
| title_full_unstemmed | Predictive value of inflammatory indexes in in-hospital mortality for patients with acute aortic dissection |
| title_short | Predictive value of inflammatory indexes in in-hospital mortality for patients with acute aortic dissection |
| title_sort | predictive value of inflammatory indexes in in hospital mortality for patients with acute aortic dissection |
| topic | Acute aortic dissection Inflammatory indexes Neutrophil-to-lymphocyte ratio Monocyte-to-lymphocyte ratio Systemic immune-inflammation index |
| url | https://doi.org/10.1186/s12872-025-04775-9 |
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