MDM4 inhibits ferroptosis in p53 mutant colon cancer via regulating TRIM21/GPX4 expression

MDM4 inhibits ferroptosis in p53 mutant colon cancer via regulating TRIM21/GPX4 expression

Abstract MDM4 is one of the major regulators of p53. The biological effect of MDM4 on tumor is controversial, its role and molecular mechanism in colon cancer progression and prognosis are still unclear. In this study, we identify that MDM4 is significantly overexpressed in human colon cancer and hi...

Full description

Saved in:
Bibliographic Details
Main Authors: Jie Liu, Xujin Wei, Yixuan Xie, Yuxiang Yan, Sihui Xue, Xiangyu Wang, Han Chen, Qilong Pan, Sisi Yan, Xiaoling Zheng, Qingling Huang
Format: Article
Language:English
Published: Nature Publishing Group 2024-11-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-07227-y
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items