Anti-inflammatory activity of collagen peptide in vitro and its effect on improving ulcerative colitis
Abstract To investigate the anti-inflammatory effects of collagen peptides, collagen peptides from cod skin were prepared to assess their in vitro anti-inflammatory effects and in vivo efficacy against ulcerative colitis. The results show that collagen peptides demonstrated anti-inflammatory effects...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | npj Science of Food |
| Online Access: | https://doi.org/10.1038/s41538-024-00367-7 |
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| author | Xuan-Ying Xin Jing Zhou Gao-Ge Liu Mei-Yu Zhang Xiang-Zi Li Yan Wang |
| author_facet | Xuan-Ying Xin Jing Zhou Gao-Ge Liu Mei-Yu Zhang Xiang-Zi Li Yan Wang |
| author_sort | Xuan-Ying Xin |
| collection | DOAJ |
| description | Abstract To investigate the anti-inflammatory effects of collagen peptides, collagen peptides from cod skin were prepared to assess their in vitro anti-inflammatory effects and in vivo efficacy against ulcerative colitis. The results show that collagen peptides demonstrated anti-inflammatory effects by inhibiting the secretion of pro-inflammatory cytokines and reducing oxidative stress in vitro. In vivo, collagen peptides significantly reduced colonic tissue damage, modulated serum cytokine balance, increased the expression of tight junction proteins ZO-1, Occludin, and Claudin-1 in colon tissue, enhanced the abundance of beneficial bacteria while reducing harmful bacteria, and restored microbial balance. In addition, collagen peptides ameliorated colitis in vivo by inhibiting the phosphorylation of NF-κB p65, IκBα and p38 MAPK in the NF-κB/MAPK signaling pathway. Based on these findings, collagen peptides could serve as potential therapeutic agents for managing ulcerative colitis. |
| format | Article |
| id | doaj-art-a95c8e5f8fb5412a99b0845abc6e7baf |
| institution | Kabale University |
| issn | 2396-8370 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Science of Food |
| spelling | doaj-art-a95c8e5f8fb5412a99b0845abc6e7baf2025-01-05T12:47:42ZengNature Portfolionpj Science of Food2396-83702025-01-019111310.1038/s41538-024-00367-7Anti-inflammatory activity of collagen peptide in vitro and its effect on improving ulcerative colitisXuan-Ying Xin0Jing Zhou1Gao-Ge Liu2Mei-Yu Zhang3Xiang-Zi Li4Yan Wang5College of Agriculture, Yabian UniversityCollege of Agriculture, Yabian UniversityCollege of Agriculture, Yabian UniversityCollege of Agriculture, Yabian UniversityEngineering Research Center of North-East Cold Region Beef Cattle Science & Technology Innovation, Ministry of Education, Department of Animal Science, Yanbian UniversityCollege of Agriculture, Yabian UniversityAbstract To investigate the anti-inflammatory effects of collagen peptides, collagen peptides from cod skin were prepared to assess their in vitro anti-inflammatory effects and in vivo efficacy against ulcerative colitis. The results show that collagen peptides demonstrated anti-inflammatory effects by inhibiting the secretion of pro-inflammatory cytokines and reducing oxidative stress in vitro. In vivo, collagen peptides significantly reduced colonic tissue damage, modulated serum cytokine balance, increased the expression of tight junction proteins ZO-1, Occludin, and Claudin-1 in colon tissue, enhanced the abundance of beneficial bacteria while reducing harmful bacteria, and restored microbial balance. In addition, collagen peptides ameliorated colitis in vivo by inhibiting the phosphorylation of NF-κB p65, IκBα and p38 MAPK in the NF-κB/MAPK signaling pathway. Based on these findings, collagen peptides could serve as potential therapeutic agents for managing ulcerative colitis.https://doi.org/10.1038/s41538-024-00367-7 |
| spellingShingle | Xuan-Ying Xin Jing Zhou Gao-Ge Liu Mei-Yu Zhang Xiang-Zi Li Yan Wang Anti-inflammatory activity of collagen peptide in vitro and its effect on improving ulcerative colitis npj Science of Food |
| title | Anti-inflammatory activity of collagen peptide in vitro and its effect on improving ulcerative colitis |
| title_full | Anti-inflammatory activity of collagen peptide in vitro and its effect on improving ulcerative colitis |
| title_fullStr | Anti-inflammatory activity of collagen peptide in vitro and its effect on improving ulcerative colitis |
| title_full_unstemmed | Anti-inflammatory activity of collagen peptide in vitro and its effect on improving ulcerative colitis |
| title_short | Anti-inflammatory activity of collagen peptide in vitro and its effect on improving ulcerative colitis |
| title_sort | anti inflammatory activity of collagen peptide in vitro and its effect on improving ulcerative colitis |
| url | https://doi.org/10.1038/s41538-024-00367-7 |
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