Proenkephalin A 119–159 in Perioperative and Intensive Care—A Promising Biomarker or Merely Another Option?
Acute kidney injury (AKI) is a severe and prevalent syndrome, primarily observed in intensive care units (ICUs) and perioperative settings. The discovery of a new biomarker for kidney function and injury, capable of overcoming the limitations of traditional markers, has the potential to improve the...
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| Language: | English |
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MDPI AG
2024-10-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/14/21/2364 |
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| author | Paulina Walczak-Wieteska Konrad Zuzda Jolanta Małyszko Paweł Andruszkiewicz |
| author_facet | Paulina Walczak-Wieteska Konrad Zuzda Jolanta Małyszko Paweł Andruszkiewicz |
| author_sort | Paulina Walczak-Wieteska |
| collection | DOAJ |
| description | Acute kidney injury (AKI) is a severe and prevalent syndrome, primarily observed in intensive care units (ICUs) and perioperative settings. The discovery of a new biomarker for kidney function and injury, capable of overcoming the limitations of traditional markers, has the potential to improve the diagnosis and management of AKI. Proenkephalin A 119–159 (PENK) has emerged as a novel biomarker for AKI and has been validated in various clinical settings. It has demonstrated a faster response to AKI compared to creatinine and has been shown to predict successful weaning from renal replacement therapy in the ICU. PENK has also shown promise as an AKI biomarker in perioperative patients. Additionally, PENK has been proven to be effective in estimating mortality and morbidity in patients undergoing cardiac surgery, and those with traumatic brain injury or ischemic stroke. Incorporating PENK into a novel estimation of the glomerular filtration rate, referred to as the PENK-Crea equation, has yielded promising results. |
| format | Article |
| id | doaj-art-a940e0850fa24c22abfd6a9fa60f0690 |
| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-a940e0850fa24c22abfd6a9fa60f06902024-11-08T14:34:41ZengMDPI AGDiagnostics2075-44182024-10-011421236410.3390/diagnostics14212364Proenkephalin A 119–159 in Perioperative and Intensive Care—A Promising Biomarker or Merely Another Option?Paulina Walczak-Wieteska0Konrad Zuzda1Jolanta Małyszko2Paweł Andruszkiewicz32nd Department of Anaesthesiology and Intensive Care, Medical University of Warsaw, 02-097 Warsaw, PolandDepartment of Nephrology, Dialysis and Internal Medicine, Medical University of Warsaw, 02-091 Warsaw, PolandDepartment of Nephrology, Dialysis and Internal Medicine, Medical University of Warsaw, 02-091 Warsaw, Poland2nd Department of Anaesthesiology and Intensive Care, Medical University of Warsaw, 02-097 Warsaw, PolandAcute kidney injury (AKI) is a severe and prevalent syndrome, primarily observed in intensive care units (ICUs) and perioperative settings. The discovery of a new biomarker for kidney function and injury, capable of overcoming the limitations of traditional markers, has the potential to improve the diagnosis and management of AKI. Proenkephalin A 119–159 (PENK) has emerged as a novel biomarker for AKI and has been validated in various clinical settings. It has demonstrated a faster response to AKI compared to creatinine and has been shown to predict successful weaning from renal replacement therapy in the ICU. PENK has also shown promise as an AKI biomarker in perioperative patients. Additionally, PENK has been proven to be effective in estimating mortality and morbidity in patients undergoing cardiac surgery, and those with traumatic brain injury or ischemic stroke. Incorporating PENK into a novel estimation of the glomerular filtration rate, referred to as the PENK-Crea equation, has yielded promising results.https://www.mdpi.com/2075-4418/14/21/2364acute kidney injurybiomarkerproenkephalin |
| spellingShingle | Paulina Walczak-Wieteska Konrad Zuzda Jolanta Małyszko Paweł Andruszkiewicz Proenkephalin A 119–159 in Perioperative and Intensive Care—A Promising Biomarker or Merely Another Option? Diagnostics acute kidney injury biomarker proenkephalin |
| title | Proenkephalin A 119–159 in Perioperative and Intensive Care—A Promising Biomarker or Merely Another Option? |
| title_full | Proenkephalin A 119–159 in Perioperative and Intensive Care—A Promising Biomarker or Merely Another Option? |
| title_fullStr | Proenkephalin A 119–159 in Perioperative and Intensive Care—A Promising Biomarker or Merely Another Option? |
| title_full_unstemmed | Proenkephalin A 119–159 in Perioperative and Intensive Care—A Promising Biomarker or Merely Another Option? |
| title_short | Proenkephalin A 119–159 in Perioperative and Intensive Care—A Promising Biomarker or Merely Another Option? |
| title_sort | proenkephalin a 119 159 in perioperative and intensive care a promising biomarker or merely another option |
| topic | acute kidney injury biomarker proenkephalin |
| url | https://www.mdpi.com/2075-4418/14/21/2364 |
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