Predictive and Prognostic Role of Lipocalin-2 Expression in Prostate Cancer and Its Association with Gleason Score
Lipocalin-2 has an important role in tumor progression, invasion, and metastasis. However, its role in prostate cancer remains unclear. The objective of this study is to determine the expression level of lipocalin-2 in human prostate cancer tissues and to evaluate the relationship between its expres...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Prostate Cancer |
| Online Access: | http://dx.doi.org/10.1155/2021/8836043 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841524563573211136 |
|---|---|
| author | M. Hakan Ulusoy Yalcin Cirak Yasemen Adali |
| author_facet | M. Hakan Ulusoy Yalcin Cirak Yasemen Adali |
| author_sort | M. Hakan Ulusoy |
| collection | DOAJ |
| description | Lipocalin-2 has an important role in tumor progression, invasion, and metastasis. However, its role in prostate cancer remains unclear. The objective of this study is to determine the expression level of lipocalin-2 in human prostate cancer tissues and to evaluate the relationship between its expression level and clinicopathologic parameters including response to docetaxel treatment, Gleason score, progression-free survival (PFS), and overall survival (OS). We retrospectively analyzed paraffin-embedded tissue sections from 33 metastatic castrate-resistant prostate cancer (mCRPC) patients whose clinical outcomes had been tracked after docetaxel treatment. The expression status of lipocalin-2 was defined by immunohistochemistry (IHC) using the anti-lipocalin-2 antibody. Lipocalin-2 was highly expressed in 36% of the examined specimens. There was no significant correlation between high lipocalin-2 expression and docetaxel response (p:0.09). High lipocalin-2 expression was significantly associated with a higher Gleason score (p=0.027). Kaplan–Meier survival analysis failed to show a significant correlation between expression levels of lipocalin-2 and both OS and PFS although patients with high lipocalin-2 levels had a numerically shorter PFS and OS time compared to patients with low levels. Consequently, it is clear that further studies are needed to evaluate the predictive and prognostic role of lipocalin-2 in prostate cancer patients. |
| format | Article |
| id | doaj-art-a93edc230dcf4e95a1db82721434f1e0 |
| institution | Kabale University |
| issn | 2090-3111 2090-312X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Prostate Cancer |
| spelling | doaj-art-a93edc230dcf4e95a1db82721434f1e02025-02-03T05:52:57ZengWileyProstate Cancer2090-31112090-312X2021-01-01202110.1155/2021/88360438836043Predictive and Prognostic Role of Lipocalin-2 Expression in Prostate Cancer and Its Association with Gleason ScoreM. Hakan Ulusoy0Yalcin Cirak1Yasemen Adali2Canakkale Onsekiz Mart University, School of Medicine, Department of Internal Medicine, Çanakkale, TurkeyCanakkale Onsekiz Mart University, School of Medicine, Department of Internal Medicine, Division of Medical Oncology, Çanakkale, TurkeyIzmir University of Economics, Faculty of Medicine, Department of Pathology, İzmir, TurkeyLipocalin-2 has an important role in tumor progression, invasion, and metastasis. However, its role in prostate cancer remains unclear. The objective of this study is to determine the expression level of lipocalin-2 in human prostate cancer tissues and to evaluate the relationship between its expression level and clinicopathologic parameters including response to docetaxel treatment, Gleason score, progression-free survival (PFS), and overall survival (OS). We retrospectively analyzed paraffin-embedded tissue sections from 33 metastatic castrate-resistant prostate cancer (mCRPC) patients whose clinical outcomes had been tracked after docetaxel treatment. The expression status of lipocalin-2 was defined by immunohistochemistry (IHC) using the anti-lipocalin-2 antibody. Lipocalin-2 was highly expressed in 36% of the examined specimens. There was no significant correlation between high lipocalin-2 expression and docetaxel response (p:0.09). High lipocalin-2 expression was significantly associated with a higher Gleason score (p=0.027). Kaplan–Meier survival analysis failed to show a significant correlation between expression levels of lipocalin-2 and both OS and PFS although patients with high lipocalin-2 levels had a numerically shorter PFS and OS time compared to patients with low levels. Consequently, it is clear that further studies are needed to evaluate the predictive and prognostic role of lipocalin-2 in prostate cancer patients.http://dx.doi.org/10.1155/2021/8836043 |
| spellingShingle | M. Hakan Ulusoy Yalcin Cirak Yasemen Adali Predictive and Prognostic Role of Lipocalin-2 Expression in Prostate Cancer and Its Association with Gleason Score Prostate Cancer |
| title | Predictive and Prognostic Role of Lipocalin-2 Expression in Prostate Cancer and Its Association with Gleason Score |
| title_full | Predictive and Prognostic Role of Lipocalin-2 Expression in Prostate Cancer and Its Association with Gleason Score |
| title_fullStr | Predictive and Prognostic Role of Lipocalin-2 Expression in Prostate Cancer and Its Association with Gleason Score |
| title_full_unstemmed | Predictive and Prognostic Role of Lipocalin-2 Expression in Prostate Cancer and Its Association with Gleason Score |
| title_short | Predictive and Prognostic Role of Lipocalin-2 Expression in Prostate Cancer and Its Association with Gleason Score |
| title_sort | predictive and prognostic role of lipocalin 2 expression in prostate cancer and its association with gleason score |
| url | http://dx.doi.org/10.1155/2021/8836043 |
| work_keys_str_mv | AT mhakanulusoy predictiveandprognosticroleoflipocalin2expressioninprostatecanceranditsassociationwithgleasonscore AT yalcincirak predictiveandprognosticroleoflipocalin2expressioninprostatecanceranditsassociationwithgleasonscore AT yasemenadali predictiveandprognosticroleoflipocalin2expressioninprostatecanceranditsassociationwithgleasonscore |