New-onset gastrointestinal disorders in COVID-19 patients 3.5 years post-infection in the inner-city population in the Bronx
Abstract This study examined the incidence, characteristics, and risk factors of new gastrointestinal disorders (GID) associated with SARS-CoV-2 infection up to 3.5 years post-infection. This retrospective study included 35,102 COVID-19 patients and 682,594 contemporary non-COVID-19 patients without...
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Nature Portfolio
2024-12-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-83232-7 |
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| author | Sagar Changela Samad Ashraf Justin Y. Lu Kevin E. Duong Sonya Henry Stephen H. Wang Tim Q. Duong |
| author_facet | Sagar Changela Samad Ashraf Justin Y. Lu Kevin E. Duong Sonya Henry Stephen H. Wang Tim Q. Duong |
| author_sort | Sagar Changela |
| collection | DOAJ |
| description | Abstract This study examined the incidence, characteristics, and risk factors of new gastrointestinal disorders (GID) associated with SARS-CoV-2 infection up to 3.5 years post-infection. This retrospective study included 35,102 COVID-19 patients and 682,594 contemporary non-COVID-19 patients without past medical history of GID (controls) from the Montefiore Health System in the Bronx (3/1/2020 to 7/31/2023). Comparisons were made with unmatched and propensity-matched (1:2) controls. The primary outcome was new GID which included peptic ulcer, inflammatory bowel disease, irritable bowel syndrome, diverticulosis, diverticulitis, and biliary disease. Multivariate Cox proportional hazards model analysis was performed with adjustment for covariates. There were 2,228 (6.34%) COVID-19 positive patients who developed new GID compared to 38,928 (5.70%) controls. COVID-19 patients had an elevated risk of developing new GID (adjusted HR = 1.18 (95% CI 1.12–1.25) compared to propensity-matched controls, after adjusting for confounders that included smoking, obesity, diabetes, hypertension. These findings underscore the need for additional research and follow-up of at-risk individuals for developing GID post infection. |
| format | Article |
| id | doaj-art-a933ad4dfda64302ad26c3f9fa078ab7 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-a933ad4dfda64302ad26c3f9fa078ab72025-01-05T12:26:23ZengNature PortfolioScientific Reports2045-23222024-12-011411910.1038/s41598-024-83232-7New-onset gastrointestinal disorders in COVID-19 patients 3.5 years post-infection in the inner-city population in the BronxSagar Changela0Samad Ashraf1Justin Y. Lu2Kevin E. Duong3Sonya Henry4Stephen H. Wang5Tim Q. Duong6Department of Radiology, Albert Einstein College of Medicine and Montefiore Medical CenterDepartment of Radiology, Albert Einstein College of Medicine and Montefiore Medical CenterDepartment of Radiology, Albert Einstein College of Medicine and Montefiore Medical CenterDepartment of Radiology, Albert Einstein College of Medicine and Montefiore Medical CenterDepartment of Radiology, Albert Einstein College of Medicine and Montefiore Medical CenterDepartment of Radiology, Albert Einstein College of Medicine and Montefiore Medical CenterDepartment of Radiology, Albert Einstein College of Medicine and Montefiore Medical CenterAbstract This study examined the incidence, characteristics, and risk factors of new gastrointestinal disorders (GID) associated with SARS-CoV-2 infection up to 3.5 years post-infection. This retrospective study included 35,102 COVID-19 patients and 682,594 contemporary non-COVID-19 patients without past medical history of GID (controls) from the Montefiore Health System in the Bronx (3/1/2020 to 7/31/2023). Comparisons were made with unmatched and propensity-matched (1:2) controls. The primary outcome was new GID which included peptic ulcer, inflammatory bowel disease, irritable bowel syndrome, diverticulosis, diverticulitis, and biliary disease. Multivariate Cox proportional hazards model analysis was performed with adjustment for covariates. There were 2,228 (6.34%) COVID-19 positive patients who developed new GID compared to 38,928 (5.70%) controls. COVID-19 patients had an elevated risk of developing new GID (adjusted HR = 1.18 (95% CI 1.12–1.25) compared to propensity-matched controls, after adjusting for confounders that included smoking, obesity, diabetes, hypertension. These findings underscore the need for additional research and follow-up of at-risk individuals for developing GID post infection.https://doi.org/10.1038/s41598-024-83232-7long covidpost-acute sequelae of COVID-19 (PASC)health disparitySARS-CoV-2 |
| spellingShingle | Sagar Changela Samad Ashraf Justin Y. Lu Kevin E. Duong Sonya Henry Stephen H. Wang Tim Q. Duong New-onset gastrointestinal disorders in COVID-19 patients 3.5 years post-infection in the inner-city population in the Bronx Scientific Reports long covid post-acute sequelae of COVID-19 (PASC) health disparity SARS-CoV-2 |
| title | New-onset gastrointestinal disorders in COVID-19 patients 3.5 years post-infection in the inner-city population in the Bronx |
| title_full | New-onset gastrointestinal disorders in COVID-19 patients 3.5 years post-infection in the inner-city population in the Bronx |
| title_fullStr | New-onset gastrointestinal disorders in COVID-19 patients 3.5 years post-infection in the inner-city population in the Bronx |
| title_full_unstemmed | New-onset gastrointestinal disorders in COVID-19 patients 3.5 years post-infection in the inner-city population in the Bronx |
| title_short | New-onset gastrointestinal disorders in COVID-19 patients 3.5 years post-infection in the inner-city population in the Bronx |
| title_sort | new onset gastrointestinal disorders in covid 19 patients 3 5 years post infection in the inner city population in the bronx |
| topic | long covid post-acute sequelae of COVID-19 (PASC) health disparity SARS-CoV-2 |
| url | https://doi.org/10.1038/s41598-024-83232-7 |
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