Ketamine does not rescue plaque load or gap detection in the 5XFAD mouse model of Alzheimer's disease

Ketamine does not rescue plaque load or gap detection in the 5XFAD mouse model of Alzheimer's disease

Ketamine has received growing attention for its effects on neuroplasticity and neuroinflammation, and as a treatment for depression and other mental health disorders. Recent evidence suggests that early sensory and behavioral deficits in Alzheimer's disease could be caused by synaptic disruptio...

Full description

Saved in:

Bibliographic Details
Main Authors:	Alexa L. Wright, Aldis P. Weible, Olivia B. Estes, Michael Wehr
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-02-01
Series:	Frontiers in Aging Neuroscience
Subjects:	gap detection behavior ketamine biomarkers auditory cortex psychoplastogens
Online Access:	https://www.frontiersin.org/articles/10.3389/fnagi.2025.1505908/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Lidocaine Versus Ketamine Pretreatment on Propofol Injection Pain
by: Amir Murad Khudadad Boujan, et al.
Published: (2019-12-01)

Rising incidence of recreational ketamine use: Clinical cases and management in emergency settings
by: Sabrina Marongiu, et al.
Published: (2025-06-01)

The effects of midazolam-ketamine and xvlazine-ketamine on arterial blobd pressure and blood gases in dogs
by: Yılmaz Koç, et al.

Modulation of the endocannabinoid system by (S)-ketamine in an animal model of depression
by: Nicole R. Silva, et al.
Published: (2025-01-01)

Intravenous Ketamine for Suicidal Behavior in Severe Depression with Psychotic Features
by: T. V. Pavan Kumar, et al.
Published: (2025-01-01)

Efficacy and safety of ketamine and esketamine in reducing the incidence of postpartum depression: an updated systematic review and meta-analysis
by: Moaz Yasser Darwish, et al.
Published: (2025-02-01)

A randomized, placebo-controlled, cross-over trial of ketamine in Rett syndrome
by: Kathleen Campbell, et al.
Published: (2025-01-01)

Intranasal Administration of the Combination of Dextro-Ketamine and Dexmedetomidine for Treatment of Diabetic Neuropathic Pain in Rats
by: Sudo SZ, et al.
Published: (2025-01-01)

Shivering Management in Spinal Anesthesia: Evaluating the Role of Ketamine: A Narrative Review
by: Siavash Sangi, et al.
Published: (2024-10-01)

Sedative Effect of Nasal Midazolam-Ketamine at Different Doses on 3-6-year-old Uncooperative Dental Patients
by: Masoud Fallahinejad Ghajari, et al.
Published: (2024-10-01)

Exploring the Effects of Sub-Dissociative Doses of Ketamine on Sedation Quality in Bronchoscopy: A Double-Blind Clinical Study
by: Hamidreza Shetabi, et al.
Published: (2024-10-01)

Auditory pathway abnormalities in Parkinson's disease
by: Rafaela Valiengo de Souza, et al.
Published: (2025-01-01)

A Comparative Study on the Effectiveness of Electroconvulsive Therapy and Ketamine in Persons Suffering from Treatment-resistant Depressive Disorder
by: Vikhram Ramasubramanian, et al.
Published: (2024-12-01)

Identification of ketamine and norketamine in dried bloodstains on crime-scene surfaces
by: Risha Jasmine Nathan, et al.
Published: (2025-01-01)

Comparison of anesthetic effects of xylazine combined with alfaxalone or ketamine and maintained with isoflurane in captive Formosan Reeve’s Muntjac (Muntiacus reevesi micrurus)
by: Li-Jen Chang, et al.
Published: (2025-02-01)

Intranasal racemic ketamine maintenance therapy for patients with treatment-resistant depression: a naturalistic feasibility study
by: Katelyn Halpape, et al.
Published: (2025-01-01)

Effects of Ketamine 0.5 mg/kgBW administration as preemptive analgesia on analgesia duration and the need for Fentanyl following hysterectomy surgery: a randomized controlled trial
by: I. Fuadi, et al.
Published: (2024-11-01)

Ketamine-associated upper urinary tract dysfunction: What we know from current literature
by: Zhihuan Zheng, et al.
Published: (2025-01-01)

Intraoperative low-dose ketamine infusion for postoperative pain relief in laparoscopic surgeries – A randomised, double blind controlled clinical trial
by: Sujil Sudersan, et al.
Published: (2024-01-01)

Comparative Analysis of Preoperative Sedation Modalities: Oral Midazolam and Ketamine Versus Chloral Hydrate and Meperidine in Pediatric Tonsillectomy - A Randomized Clinical Trial
by: Nima Naderi, et al.
Published: (2024-09-01)

Application of a nucleophilic substitution reaction for spectrofluorimetric quantification of ketamine in pharmaceutical and plasma matrices
by: Reem M. Alnemari, et al.
Published: (2024-12-01)

Outcomes and physiologic responses associated with ketamine administration after traumatic brain injury in the United States and Canada: a retrospective analysis
by: Austin J. Peters, et al.
Published: (2023-12-01)

Comparative antidepressant effects and safety of intravenous racemic ketamine, psilocybin and theta burst stimulation for major depressive disorder: A systematic review and network meta‐analyses of randomized controlled trials
by: Itsuki Terao, et al.
Published: (2024-12-01)

Comparative Evaluation of Regain of Consciousness in Dexmedetomidine–Propofol versus Ketamine–Propofol in the Pediatric Cardiac Catheterization Procedure under Sedation using BIS Monitoring: A Randomized Prospective Study
by: Priya Banga, et al.
Published: (2025-01-01)

Comparison of intravenous dexmedetomidine versus ketamine–dexmedetomidine combination on spinal block characteristics in patients undergoing lower limb orthopaedic surgery – A randomised clinical trial
by: Annapureddy Sai Krishna, et al.
Published: (2024-09-01)

Modeling of auditory neuropathy spectrum disorders associated with the TEME43 variant reveals impaired gap junction function of iPSC-derived glia-like support cells
by: Xiaoming Kang, et al.
Published: (2025-01-01)

Ketamine effects on resting state functional brain connectivity in major depressive disorder patients: a hypothesis-driven analysis based on a network model of depression
by: Kasper Recourt, et al.
Published: (2025-02-01)

Ketamine Infusion as an Adjunct to Opioid Analgesia in Pediatric Patients with High-Risk Neuroblastoma Undergoing Treatment with Dinutuximab: Adverse Effects and Safety in a Non-ICU Setting
by: Streby KA, et al.
Published: (2025-01-01)

Preparatory Switches of Auditory Spatial and Non-Spatial Attention Among Simultaneous Voices
by: Aureliu Lavric, et al.
Published: (2025-01-01)

Das Kind mit APD und CAPD: Untersuchung zentraler auditiver Verarbeitungsstörungen und der Wirksamkeit des Hörtrainings
by: Agnieszka Kuniczuk
Published: (2025-02-01)

A COMPARATIVE STUDY BETWEEN WATER-GAP AND AIR-GAP DISTILLATION MEMBRANES FOR REMOVAL OF SALTS FROM SALINE WATER BY DESALINATION METHOD
by: LAURENTIU TATARU, et al.
Published: (2018-06-01)

English Slang in “Gap Year” Movies Series
by: Rahilla Fanny Fanny
Published: (2021-01-01)

Ethical Analysis of the Responsibility Gap in Artificial Intelligence
by: Eva Schur, et al.
Published: (2025-01-01)

Central auditory system assessment in children and adolescents with cystic fibrosis: electrophysiology and central auditory processing
by: Paula Maria Martins-Duarte, et al.
Published: (2025-01-01)

Trends in research on novel antidepressant treatments
by: Agnieszka Zelek-Molik, et al.
Published: (2025-01-01)

Synaptic plasticity in fronto-insular circuits underlying stress susceptibility and resilience
by: Devin Rocks, et al.
Published: (2025-02-01)

Brief communication: gaps and opportunities in HIV research in Venezuela
by: Jesús A. Morgado, et al.
Published: (2025-01-01)

Effect of Auditory Integration Training on Children with Autism Spectrum Disorder and Auditory Attention Disorder
by: HUANG Qijun, et al.
Published: (2022-08-01)

“It will discourse most eloquent music”: Sonifying Variants of Hamlet
by: Iain Emsley, et al.
Published: (2017-01-01)

Completeness classes for intuitionistic first-order temporal logic with time gaps
by: Romas Alonderis
Published: (2023-11-01)