Case Report: SMARCB1-deficient phenotype may be a new specialized type of pleomorphic xanthoastrocytoma associated with poor prognosis

Case Report: SMARCB1-deficient phenotype may be a new specialized type of pleomorphic xanthoastrocytoma associated with poor prognosis

Pleomorphic xanthoastrocytoma (PXA) is a rare, localized glioma characterized by frequent BRAF V600E mutations and CDKN2A/B deletions. Compared to IDH-wildtype glioblastoma, PXA has a better prognosis. Recently, rare cases of PXA with rhabdoid histological characteristics have been reported, which a...

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Bibliographic Details
Main Authors: Hui Zhang, Xueping Xiang, Xiaojing Ma, Buyi Zhang, Susu Xu, Xiaojuan He, Jinghong Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Oncology
Subjects:
pleomorphic xanthoastrocytoma
SMARCB1
deficiency
DNA methylation profile
genetic characteristics
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1527909/full
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