The association between PSCA gene polymorphism and hepatocellular carcinoma risk
Abstract Background The current study aims to determine whether prostate stem cell antigen (PSCA) gene polymorphism confers a risk for hepatocellular carcinoma (HCC). The aim is to find out the novel markers for predicting HCC risk and provide an early warning mechanism for the population susceptibl...
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| Format: | Article |
| Language: | English |
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BMC
2025-06-01
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| Series: | World Journal of Surgical Oncology |
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| Online Access: | https://doi.org/10.1186/s12957-025-03878-z |
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| author | Xiechen Wang Xiaoqiang Sun Xuyin Wang Yongqiang Wang Hongmei Zhao Jun Ma |
| author_facet | Xiechen Wang Xiaoqiang Sun Xuyin Wang Yongqiang Wang Hongmei Zhao Jun Ma |
| author_sort | Xiechen Wang |
| collection | DOAJ |
| description | Abstract Background The current study aims to determine whether prostate stem cell antigen (PSCA) gene polymorphism confers a risk for hepatocellular carcinoma (HCC). The aim is to find out the novel markers for predicting HCC risk and provide an early warning mechanism for the population susceptible to HCC. Methods A case-control study was used to select 160 HCC patients who were admitted to People’s Hospital of Ningxia Hui Autonomous Region between May 2021 and April 2024 as the case group, and 280 healthy adults matching the gender and age of the case group were collected as the normal control group. PSCA gene polymorphism was detected using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). At the same time, whether the interaction of gene and smokers affects polymorphism is also investigated. Results Significant associations were found at the rs2294008 and rs2976392 loci of PSCA gene (P < 0.05). However, there were no significant differences at the rs1045531 or rs2978974 loci (P > 0.05). All HCC patients were divided into smokers and non-smokers. The final results did not show any significant difference in genotype frequency between the two groups. Conclusion The PSCA rs2294008 and rs2976392 polymorphisms contribute to an increased risk of HCC and serve as two novel markers for predicting HCC risk. |
| format | Article |
| id | doaj-art-a8eadc7e2f7e4c9f817bc5b5575a8bd1 |
| institution | Kabale University |
| issn | 1477-7819 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj-art-a8eadc7e2f7e4c9f817bc5b5575a8bd12025-08-20T03:45:11ZengBMCWorld Journal of Surgical Oncology1477-78192025-06-0123111010.1186/s12957-025-03878-zThe association between PSCA gene polymorphism and hepatocellular carcinoma riskXiechen Wang0Xiaoqiang Sun1Xuyin Wang2Yongqiang Wang3Hongmei Zhao4Jun Ma5Interventional vascular surgery, Ningxia Hui Autonomous Region People’s Hospital, Ningxia Hui Autonomous RegionInterventional vascular surgery, Ningxia Hui Autonomous Region People’s Hospital, Ningxia Hui Autonomous RegionInterventional vascular surgery, Ningxia Hui Autonomous Region People’s Hospital, Ningxia Hui Autonomous RegionDigestive Medical Oncology, Pingluo County People’s Hospital, Ningxia Hui Autonomous Region, Ningxia Hui Autonomous RegionFunctional Section, Pingluo County People’s Hospital, Ningxia Hui Autonomous Region, Ningxia Hui Autonomous RegionInterventional vascular surgery, Ningxia Hui Autonomous Region People’s Hospital, Ningxia Hui Autonomous RegionAbstract Background The current study aims to determine whether prostate stem cell antigen (PSCA) gene polymorphism confers a risk for hepatocellular carcinoma (HCC). The aim is to find out the novel markers for predicting HCC risk and provide an early warning mechanism for the population susceptible to HCC. Methods A case-control study was used to select 160 HCC patients who were admitted to People’s Hospital of Ningxia Hui Autonomous Region between May 2021 and April 2024 as the case group, and 280 healthy adults matching the gender and age of the case group were collected as the normal control group. PSCA gene polymorphism was detected using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). At the same time, whether the interaction of gene and smokers affects polymorphism is also investigated. Results Significant associations were found at the rs2294008 and rs2976392 loci of PSCA gene (P < 0.05). However, there were no significant differences at the rs1045531 or rs2978974 loci (P > 0.05). All HCC patients were divided into smokers and non-smokers. The final results did not show any significant difference in genotype frequency between the two groups. Conclusion The PSCA rs2294008 and rs2976392 polymorphisms contribute to an increased risk of HCC and serve as two novel markers for predicting HCC risk.https://doi.org/10.1186/s12957-025-03878-zHepatocellular carcinomaPSCAGene polymorphismNovel marker |
| spellingShingle | Xiechen Wang Xiaoqiang Sun Xuyin Wang Yongqiang Wang Hongmei Zhao Jun Ma The association between PSCA gene polymorphism and hepatocellular carcinoma risk World Journal of Surgical Oncology Hepatocellular carcinoma PSCA Gene polymorphism Novel marker |
| title | The association between PSCA gene polymorphism and hepatocellular carcinoma risk |
| title_full | The association between PSCA gene polymorphism and hepatocellular carcinoma risk |
| title_fullStr | The association between PSCA gene polymorphism and hepatocellular carcinoma risk |
| title_full_unstemmed | The association between PSCA gene polymorphism and hepatocellular carcinoma risk |
| title_short | The association between PSCA gene polymorphism and hepatocellular carcinoma risk |
| title_sort | association between psca gene polymorphism and hepatocellular carcinoma risk |
| topic | Hepatocellular carcinoma PSCA Gene polymorphism Novel marker |
| url | https://doi.org/10.1186/s12957-025-03878-z |
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