Reduced cross-protective potential of Omicron compared to ancestral SARS-CoV-2 spike vaccines against potentially zoonotic coronaviruses
Abstract The COVID-19 pandemic has emphasised the importance of vaccines and preparedness against viral threats crossing species barriers. In response, a worldwide vaccination campaign targeting SARS-CoV-2 was implemented, which provides some cross-protective immunological memory to other coronaviru...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-11-01
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| Series: | npj Viruses |
| Online Access: | https://doi.org/10.1038/s44298-024-00067-9 |
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| _version_ | 1846158759991181312 |
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| author | Tyler M. Renner Matthew Stuible Brian Cass Sylvie Perret Julie Guimond Simon Lord-Dufour Michael J. McCluskie Yves Durocher Bassel Akache |
| author_facet | Tyler M. Renner Matthew Stuible Brian Cass Sylvie Perret Julie Guimond Simon Lord-Dufour Michael J. McCluskie Yves Durocher Bassel Akache |
| author_sort | Tyler M. Renner |
| collection | DOAJ |
| description | Abstract The COVID-19 pandemic has emphasised the importance of vaccines and preparedness against viral threats crossing species barriers. In response, a worldwide vaccination campaign targeting SARS-CoV-2 was implemented, which provides some cross-protective immunological memory to other coronavirus species with zoonotic potential. Following a vaccination regimen against SARS-CoV-2 spike in a preclinical mouse model, we were able to demonstrate the induction of neutralizing antibodies towards multiple human ACE2 (hACE2)-binding Sarbecovirus spikes. Importantly, compared to vaccines based on the SARS-CoV-2 Reference strain, vaccines based on Omicron spike sequences induced drastically less broadly cross-protective neutralizing antibodies against other hACE2-binding sarbecoviruses. This observation remained true whether the vaccination regimens were based on protein subunit or mRNA / LNP vaccines. Overall, while it may be necessary to update vaccine antigens to combat the evolving SARS-CoV-2 virus for enhanced protection from COVID-19, Reference-based vaccines may be a more valuable tool to protect against novel coronavirus zoonoses. |
| format | Article |
| id | doaj-art-a8d0af306892431ba70122d09fbd30e1 |
| institution | Kabale University |
| issn | 2948-1767 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Viruses |
| spelling | doaj-art-a8d0af306892431ba70122d09fbd30e12024-11-24T12:14:14ZengNature Portfolionpj Viruses2948-17672024-11-01211810.1038/s44298-024-00067-9Reduced cross-protective potential of Omicron compared to ancestral SARS-CoV-2 spike vaccines against potentially zoonotic coronavirusesTyler M. Renner0Matthew Stuible1Brian Cass2Sylvie Perret3Julie Guimond4Simon Lord-Dufour5Michael J. McCluskie6Yves Durocher7Bassel Akache8National Research Council Canada, Human Health TherapeuticsNational Research Council Canada, Human Health TherapeuticsNational Research Council Canada, Human Health TherapeuticsNational Research Council Canada, Human Health TherapeuticsNational Research Council Canada, Human Health TherapeuticsNational Research Council Canada, Human Health TherapeuticsNational Research Council Canada, Human Health TherapeuticsNational Research Council Canada, Human Health TherapeuticsNational Research Council Canada, Human Health TherapeuticsAbstract The COVID-19 pandemic has emphasised the importance of vaccines and preparedness against viral threats crossing species barriers. In response, a worldwide vaccination campaign targeting SARS-CoV-2 was implemented, which provides some cross-protective immunological memory to other coronavirus species with zoonotic potential. Following a vaccination regimen against SARS-CoV-2 spike in a preclinical mouse model, we were able to demonstrate the induction of neutralizing antibodies towards multiple human ACE2 (hACE2)-binding Sarbecovirus spikes. Importantly, compared to vaccines based on the SARS-CoV-2 Reference strain, vaccines based on Omicron spike sequences induced drastically less broadly cross-protective neutralizing antibodies against other hACE2-binding sarbecoviruses. This observation remained true whether the vaccination regimens were based on protein subunit or mRNA / LNP vaccines. Overall, while it may be necessary to update vaccine antigens to combat the evolving SARS-CoV-2 virus for enhanced protection from COVID-19, Reference-based vaccines may be a more valuable tool to protect against novel coronavirus zoonoses.https://doi.org/10.1038/s44298-024-00067-9 |
| spellingShingle | Tyler M. Renner Matthew Stuible Brian Cass Sylvie Perret Julie Guimond Simon Lord-Dufour Michael J. McCluskie Yves Durocher Bassel Akache Reduced cross-protective potential of Omicron compared to ancestral SARS-CoV-2 spike vaccines against potentially zoonotic coronaviruses npj Viruses |
| title | Reduced cross-protective potential of Omicron compared to ancestral SARS-CoV-2 spike vaccines against potentially zoonotic coronaviruses |
| title_full | Reduced cross-protective potential of Omicron compared to ancestral SARS-CoV-2 spike vaccines against potentially zoonotic coronaviruses |
| title_fullStr | Reduced cross-protective potential of Omicron compared to ancestral SARS-CoV-2 spike vaccines against potentially zoonotic coronaviruses |
| title_full_unstemmed | Reduced cross-protective potential of Omicron compared to ancestral SARS-CoV-2 spike vaccines against potentially zoonotic coronaviruses |
| title_short | Reduced cross-protective potential of Omicron compared to ancestral SARS-CoV-2 spike vaccines against potentially zoonotic coronaviruses |
| title_sort | reduced cross protective potential of omicron compared to ancestral sars cov 2 spike vaccines against potentially zoonotic coronaviruses |
| url | https://doi.org/10.1038/s44298-024-00067-9 |
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