Does pathological complete response after neoadjuvant chemoradiotherapy associate with long-term survival in esophageal cancer: A systematic review and meta-analysis
Abstract This meta-analysis examines the impact of pathological complete response (pCR) on long-term survival in locally advanced esophageal cancer patients treated with neoadjuvant chemoradiotherapy (NCRT) and surgery. A systematic review of 38 studies found that pCR correlates with improved overal...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-07-01
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| Series: | BMC Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12893-025-03016-2 |
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| Summary: | Abstract This meta-analysis examines the impact of pathological complete response (pCR) on long-term survival in locally advanced esophageal cancer patients treated with neoadjuvant chemoradiotherapy (NCRT) and surgery. A systematic review of 38 studies found that pCR correlates with improved overall survival (HR = 0.54) and disease-free survival (HR = 0.51). The findings suggest that pCR may serve as a surrogate endpoint for evaluating the survival outcomes of NCRT. |
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| ISSN: | 1471-2482 |