Berberrubine protects against cisplatin-induced ototoxicity by promoting folate biosynthesis

Berberrubine protects against cisplatin-induced ototoxicity by promoting folate biosynthesis

ObjectiveThis research investigated the possible shielding properties of BB (Berberrubine) against the harmful auditory effects of cisplatin, preliminarily delving into the underlying mechanisms responsible for this protection.MethodsHEI-OC1 cell viability was determined using a Cell Counting Kit-8...

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Bibliographic Details
Main Authors: Zhuang Miao, Danyang Chang, Xiaodong Du, Changling Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pharmacology
Subjects:
berberrubine
cisplatin
ototoxicity
hair cells
folate
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1496917/full
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