Synthesis and Characterization of Novel Benzimidazole Derivatives using CdO NPs and their Application as Antibacterial and Antifungal Agents
Background: Benzimidazoles are a class of compounds characterized by a fusion of benzene and imidazole rings. This unique structure endows them with a broad spectrum of biological activities, making them invaluable in medicinal and pharmaceutical research. The benzene ring provides aromatic stabili...
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Mustansiriyah University
2024-12-01
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| Series: | Al-Mustansiriyah Journal of Science |
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| Online Access: | https://mjs.uomustansiriyah.edu.iq/index.php/MJS/article/view/1572 |
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| author | Asmaa M. Abdullah Abdull Jabar Kh. Attia Sergei N. Shtykov |
| author_facet | Asmaa M. Abdullah Abdull Jabar Kh. Attia Sergei N. Shtykov |
| author_sort | Asmaa M. Abdullah |
| collection | DOAJ |
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Background: Benzimidazoles are a class of compounds characterized by a fusion of benzene and imidazole rings. This unique structure endows them with a broad spectrum of biological activities, making them invaluable in medicinal and pharmaceutical research. The benzene ring provides aromatic stability, while the imidazole ring offers a site for various chemical modifications, enhancing their versatility and functionality. Benzimidazoles are known for their diverse pharmacological properties, including antimicrobial, antiviral, anticancer, anti-inflammatory, and antiparasitic. Objective: Synthesis of new benzimidazole derivatives and their application as antibacterial and antifungal agents. Methods: The benzimidazole derivatives (A1-A5) were synthesized in high yields by condensing 2-(4-hydroxyphenyl) benzimidazole with different aldehydes (p- nitro benzaldehyde and p- bromo benzaldehyde) and amides (benzamide and acetamide) utilizing cadmium oxide nanoparticle (CdO NPs) as a catalyst. Results: The synthesized benzimidazole derivatives (A1-A5) were characterized using FTIR and 1HNMR spectra, and showed good antibacterial activity (inhibition zone: 5-23 mm) with various concentrations (250, 500, and 1000 mg/L) while the compounds (A1, A3, A4, and A5) also exhibited moderate antifungal activities (inhibition zone: 5-10 mm) except the A2 compound. Conclusions: The antimicrobial and antifungal effectiveness of these synthesized derivatives was evaluated, showing satisfactory antimicrobial activity and suitable antifungal activity for all except the A2 compound. It is recommended that further research and structural modifications of these derivatives be conducted to develop more potent benzimidazole derivatives.
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| format | Article |
| id | doaj-art-a8aa34e7b1b84c19981d8b4dac09218b |
| institution | Kabale University |
| issn | 1814-635X 2521-3520 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Mustansiriyah University |
| record_format | Article |
| series | Al-Mustansiriyah Journal of Science |
| spelling | doaj-art-a8aa34e7b1b84c19981d8b4dac09218b2025-01-03T05:01:21ZengMustansiriyah UniversityAl-Mustansiriyah Journal of Science1814-635X2521-35202024-12-0135410.23851/mjs.v35i4.1572Synthesis and Characterization of Novel Benzimidazole Derivatives using CdO NPs and their Application as Antibacterial and Antifungal AgentsAsmaa M. Abdullah0https://orcid.org/0009-0003-6763-8244Abdull Jabar Kh. Attia1https://orcid.org/0009-0003-6875-8352Sergei N. Shtykov2https://orcid.org/0000-0001-6753-5040Department of Chemistry, College of Science, Mustansiriyah University, Baghdad, IraqDepartment of Chemistry, College of Science, Mustansiriyah University, Baghdad, IraqDepartment of Analytical Chemistry and Chemical Ecology, Institute of Chemistry, Saratov State University, Saratov, Russian Federation Background: Benzimidazoles are a class of compounds characterized by a fusion of benzene and imidazole rings. This unique structure endows them with a broad spectrum of biological activities, making them invaluable in medicinal and pharmaceutical research. The benzene ring provides aromatic stability, while the imidazole ring offers a site for various chemical modifications, enhancing their versatility and functionality. Benzimidazoles are known for their diverse pharmacological properties, including antimicrobial, antiviral, anticancer, anti-inflammatory, and antiparasitic. Objective: Synthesis of new benzimidazole derivatives and their application as antibacterial and antifungal agents. Methods: The benzimidazole derivatives (A1-A5) were synthesized in high yields by condensing 2-(4-hydroxyphenyl) benzimidazole with different aldehydes (p- nitro benzaldehyde and p- bromo benzaldehyde) and amides (benzamide and acetamide) utilizing cadmium oxide nanoparticle (CdO NPs) as a catalyst. Results: The synthesized benzimidazole derivatives (A1-A5) were characterized using FTIR and 1HNMR spectra, and showed good antibacterial activity (inhibition zone: 5-23 mm) with various concentrations (250, 500, and 1000 mg/L) while the compounds (A1, A3, A4, and A5) also exhibited moderate antifungal activities (inhibition zone: 5-10 mm) except the A2 compound. Conclusions: The antimicrobial and antifungal effectiveness of these synthesized derivatives was evaluated, showing satisfactory antimicrobial activity and suitable antifungal activity for all except the A2 compound. It is recommended that further research and structural modifications of these derivatives be conducted to develop more potent benzimidazole derivatives. https://mjs.uomustansiriyah.edu.iq/index.php/MJS/article/view/1572Benzimidazole CdO NPsAntibacterialAntifungalNMR spectroscopy |
| spellingShingle | Asmaa M. Abdullah Abdull Jabar Kh. Attia Sergei N. Shtykov Synthesis and Characterization of Novel Benzimidazole Derivatives using CdO NPs and their Application as Antibacterial and Antifungal Agents Al-Mustansiriyah Journal of Science Benzimidazole CdO NPs Antibacterial Antifungal NMR spectroscopy |
| title | Synthesis and Characterization of Novel Benzimidazole Derivatives using CdO NPs and their Application as Antibacterial and Antifungal Agents |
| title_full | Synthesis and Characterization of Novel Benzimidazole Derivatives using CdO NPs and their Application as Antibacterial and Antifungal Agents |
| title_fullStr | Synthesis and Characterization of Novel Benzimidazole Derivatives using CdO NPs and their Application as Antibacterial and Antifungal Agents |
| title_full_unstemmed | Synthesis and Characterization of Novel Benzimidazole Derivatives using CdO NPs and their Application as Antibacterial and Antifungal Agents |
| title_short | Synthesis and Characterization of Novel Benzimidazole Derivatives using CdO NPs and their Application as Antibacterial and Antifungal Agents |
| title_sort | synthesis and characterization of novel benzimidazole derivatives using cdo nps and their application as antibacterial and antifungal agents |
| topic | Benzimidazole CdO NPs Antibacterial Antifungal NMR spectroscopy |
| url | https://mjs.uomustansiriyah.edu.iq/index.php/MJS/article/view/1572 |
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