Exploring the role of Fusobacterium nucleatum in colorectal cancer: implications for tumor proliferation and chemoresistance
Abstract Fusobacterium nucleatum (Fn) has been extensively studied for its connection to colorectal cancer (CRC) and its potential role in chemotherapy resistance. Studies indicate that Fn is commonly found in CRC tissues and is associated with unfavorable prognosis and treatment failure. It has bee...
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| Format: | Article |
| Language: | English |
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BMC
2024-11-01
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| Series: | Cell Communication and Signaling |
| Online Access: | https://doi.org/10.1186/s12964-024-01909-y |
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| author | Leila Dadgar-Zankbar Zahra Elahi Aref Shariati Azad Khaledi Shabnam Razavi Amin Khoshbayan |
| author_facet | Leila Dadgar-Zankbar Zahra Elahi Aref Shariati Azad Khaledi Shabnam Razavi Amin Khoshbayan |
| author_sort | Leila Dadgar-Zankbar |
| collection | DOAJ |
| description | Abstract Fusobacterium nucleatum (Fn) has been extensively studied for its connection to colorectal cancer (CRC) and its potential role in chemotherapy resistance. Studies indicate that Fn is commonly found in CRC tissues and is associated with unfavorable prognosis and treatment failure. It has been shown that Fn promotes chemoresistance by affecting autophagy, a cellular process that helps cells survive under stressful conditions. Additionally, Fn targets specific signaling pathways that activate particular microRNAs and modulate the response to chemotherapy. Understanding the current molecular mechanisms and investigating the importance of Fn-inducing chemoresistance could provide valuable insights for developing novel therapies. This review surveys the role of Fn in tumor proliferation, metastasis, and chemoresistance in CRC, focusing on its effects on the tumor microenvironment, gene expression, and resistance to conventional chemotherapy drugs. It also discusses the therapeutic implications of targeting Fn in CRC treatment and highlights the need for further research. |
| format | Article |
| id | doaj-art-a8a57a51752b4314a0de675060d8b0af |
| institution | Kabale University |
| issn | 1478-811X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj-art-a8a57a51752b4314a0de675060d8b0af2024-11-17T12:38:46ZengBMCCell Communication and Signaling1478-811X2024-11-0122111610.1186/s12964-024-01909-yExploring the role of Fusobacterium nucleatum in colorectal cancer: implications for tumor proliferation and chemoresistanceLeila Dadgar-Zankbar0Zahra Elahi1Aref Shariati2Azad Khaledi3Shabnam Razavi4Amin Khoshbayan5Department of Microbiology, School of Medicine, Iran University of Medical SciencesDepartment of Microbiology, School of Medicine, Iran University of Medical SciencesInfectious Diseases Research Center (IDRC), Arak University of Medical SciencesInfectious Diseases Research Center, Kashan University of Medical SciencesDepartment of Microbiology, School of Medicine, Iran University of Medical SciencesDepartment of Microbiology, School of Medicine, Iran University of Medical SciencesAbstract Fusobacterium nucleatum (Fn) has been extensively studied for its connection to colorectal cancer (CRC) and its potential role in chemotherapy resistance. Studies indicate that Fn is commonly found in CRC tissues and is associated with unfavorable prognosis and treatment failure. It has been shown that Fn promotes chemoresistance by affecting autophagy, a cellular process that helps cells survive under stressful conditions. Additionally, Fn targets specific signaling pathways that activate particular microRNAs and modulate the response to chemotherapy. Understanding the current molecular mechanisms and investigating the importance of Fn-inducing chemoresistance could provide valuable insights for developing novel therapies. This review surveys the role of Fn in tumor proliferation, metastasis, and chemoresistance in CRC, focusing on its effects on the tumor microenvironment, gene expression, and resistance to conventional chemotherapy drugs. It also discusses the therapeutic implications of targeting Fn in CRC treatment and highlights the need for further research.https://doi.org/10.1186/s12964-024-01909-y |
| spellingShingle | Leila Dadgar-Zankbar Zahra Elahi Aref Shariati Azad Khaledi Shabnam Razavi Amin Khoshbayan Exploring the role of Fusobacterium nucleatum in colorectal cancer: implications for tumor proliferation and chemoresistance Cell Communication and Signaling |
| title | Exploring the role of Fusobacterium nucleatum in colorectal cancer: implications for tumor proliferation and chemoresistance |
| title_full | Exploring the role of Fusobacterium nucleatum in colorectal cancer: implications for tumor proliferation and chemoresistance |
| title_fullStr | Exploring the role of Fusobacterium nucleatum in colorectal cancer: implications for tumor proliferation and chemoresistance |
| title_full_unstemmed | Exploring the role of Fusobacterium nucleatum in colorectal cancer: implications for tumor proliferation and chemoresistance |
| title_short | Exploring the role of Fusobacterium nucleatum in colorectal cancer: implications for tumor proliferation and chemoresistance |
| title_sort | exploring the role of fusobacterium nucleatum in colorectal cancer implications for tumor proliferation and chemoresistance |
| url | https://doi.org/10.1186/s12964-024-01909-y |
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