Mechanism of dexmedetomidine protection against cisplatin induced acute kidney injury in rats

Mechanism of dexmedetomidine protection against cisplatin induced acute kidney injury in rats

Objective This study explored the molecular mechanisms by which dexmedetomidine (Dex) alleviates cisplatin (CP)-induced acute kidney injury (AKI) in rats.Methods CP-induced AKI models were established, and Dex was intraperitoneally injected at different concentrations into rats in the model groups....

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Bibliographic Details
Main Authors: Zeng-lu Zheng, Jun-wei Ma, Yi Luo, Gui-jin Liang, Shi-jie Lei, Ke-jin Yan, Hai-bing Meng, Xiu-juan Liu
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Renal Failure
Subjects:
Dexmedetomidine
acute kidney injury
cisplatin
NLRP-3/caspase-1 signaling pathway
pyroptosis
Online Access:https://www.tandfonline.com/doi/10.1080/0886022X.2024.2337287
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