The novel orthosteric agonist M1 muscarinic acetylcholine receptor reveals anti-Alzheimer’s disease activity

The novel orthosteric agonist M1 muscarinic acetylcholine receptor reveals anti-Alzheimer’s disease activity

Abstract Cholinergic treatments with an emphasis on M1 muscarinic acetylcholine receptor (mAChR) agonists as potential modulating agents are a new approach in Alzheimer’s disease (AD) therapy. In previous research, we designed and characterized novel thiazolidine-2,4-dione (TZD)-derived compounds th...

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Bibliographic Details
Main Authors:	Maryam Taheri, Maryam Afzali Mehr, Hossein Ghafouri
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-11-01
Series:	Scientific Reports
Subjects:	Alzheimer’s disease (AD) Cholinergic pathway Agonist M1 muscarinic acetylcholine receptor Orthosteric site Thiazolidine-2,4-dione (TZD)
Online Access:	https://doi.org/10.1038/s41598-024-80102-0
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