Prevalence of psoriatic arthritis in Italy: insights from the multicentric MAPSI study
IntroductionPsoriatic arthritis (PsA) is a chronic inflammatory arthropathy associated with cutaneous psoriasis (PsO), first defined by Moll and Wright. Initially perceived as relatively benign, PsA is now recognized for its chronic, progressive, and destructive nature, significantly impacting patie...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1484988/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841536812897533952 |
|---|---|
| author | Teodora Serban Giuseppina Tramontano Monica Pendolino Dario Roccatello Oscar Massimiliano Epis Florienzo Iannone Ilenia De Andres Marta Favero Nicoletta Romeo Guido Rovera Leonardo Santo Enrico Tirri Alberto Bergamini Roberta Foti Carlotta Schenone Gerolamo Bianchi |
| author_facet | Teodora Serban Giuseppina Tramontano Monica Pendolino Dario Roccatello Oscar Massimiliano Epis Florienzo Iannone Ilenia De Andres Marta Favero Nicoletta Romeo Guido Rovera Leonardo Santo Enrico Tirri Alberto Bergamini Roberta Foti Carlotta Schenone Gerolamo Bianchi |
| author_sort | Teodora Serban |
| collection | DOAJ |
| description | IntroductionPsoriatic arthritis (PsA) is a chronic inflammatory arthropathy associated with cutaneous psoriasis (PsO), first defined by Moll and Wright. Initially perceived as relatively benign, PsA is now recognized for its chronic, progressive, and destructive nature, significantly impacting patients' quality of life, similar to Rheumatoid Arthritis (RA). Globally, PsA represents about 20% of cases in early arthritis clinics, posing diagnostic and management challenges. Early diagnosis is crucial to prevent long-term disability and prevent comorbidities. While classification criteria for PsA are widely accepted, the lack of specific diagnostic criteria may delay diagnosis, with many patients experiencing delays of over a year before receiving an accurate diagnosis. For this reason, the exact prevalence of PsA remains uncertain.MethodsThe MAnagement of PSoriatic Arthritis in Italy (MAPSI) project is a multicenter observational study aimed to investigate the prevalence of PsA and characteristics in an Italian cohort. This study included 454 patients diagnosed or confirmed by a rheumatologist across 25 Rheumatology Units in Italy. Data were collected on demographics, clinical features, and treatment histories. In our cohort, distinct gender differences were observed in PsA phenotype and disease impact.ResultsMen had a higher prevalence of axial involvement and were more likely to be current or former smokers, while women showed greater rates of enthesitis and reported higher perceived disease activity. Additionally, women had a higher prevalence of psychological comorbidities, whereas men had more severe skin involvement; laboratory tests were often unhelpful in diagnosing PsA, with elevated inflammatory markers in only about half of the cases.DiscussionThese findings highlight the need for gender-sensitive approaches in the management of PsA. Our findings highlight the importance of comprehensive patient evaluation, including extramuscoloskeletal manifestation with a gender-sensitive approaches, focusing on a prompt diagnosis to prevent systemic comorbidities. Real-world data, such as those provided by the MAPSI study, are essential for understanding the burden of PsA and developing effective management strategies tailored to patient characteristics. |
| format | Article |
| id | doaj-art-a8368db1b9704a25a4dfe400e309edbd |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-a8368db1b9704a25a4dfe400e309edbd2025-01-14T10:51:08ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011110.3389/fmed.2024.14849881484988Prevalence of psoriatic arthritis in Italy: insights from the multicentric MAPSI studyTeodora Serban0Giuseppina Tramontano1Monica Pendolino2Dario Roccatello3Oscar Massimiliano Epis4Florienzo Iannone5Ilenia De Andres6Marta Favero7Nicoletta Romeo8Guido Rovera9Leonardo Santo10Enrico Tirri11Alberto Bergamini12Roberta Foti13Carlotta Schenone14Gerolamo Bianchi15S.C. Reumatologia, ASL3 Genovese, Genoa, ItalyS.C. Reumatologia, ASL3 Genovese, Genoa, ItalyS.C. Reumatologia, ASL3 Genovese, Genoa, ItalyUniversity Center of Excellence on Nephrologic, Rheumatologic and Rare Diseases (ERK-net, ERN-Reconnect and RITA-ERN Member), ASL Città di Torino and Department of Clinical and Biological Sciences, University of Turin, Turin, ItalyDivision of Rheumatology, Multispecialist Medical Department, Grande Ospedale Metropolitano Niguarda, Milan, ItalyRheumatology Unit, DiMePRE-J, University of Bari, Bari, ItalyRheumatology Unit, Azienda Ospedaliera di Rilievo Nazionale ed Alta Specializzazione “Garibaldi”, Catania, ItalyInternal Medicine 1, Ca’ Foncello University Hospital, AULSS2, Treviso, ItalyAzienda Ospedaliera S Croce e Carle, Cuneo, ItalyNuclear Medicine Division, Department of Medical Sciences, University of Turin, Turin, ItalyRheumatology Unit, “Mons. Dimiccoli” Hospital, Barletta, Italy0UOSD di Reumatologia, Ospedale San Giovanni Bosco, Napoli, Italy1Rheumatology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy2Division of Rheumatology, A.O.U. “Policlinico-San Marco”, Catania, ItalyS.C. Reumatologia, ASL3 Genovese, Genoa, ItalyS.C. Reumatologia, ASL3 Genovese, Genoa, ItalyIntroductionPsoriatic arthritis (PsA) is a chronic inflammatory arthropathy associated with cutaneous psoriasis (PsO), first defined by Moll and Wright. Initially perceived as relatively benign, PsA is now recognized for its chronic, progressive, and destructive nature, significantly impacting patients' quality of life, similar to Rheumatoid Arthritis (RA). Globally, PsA represents about 20% of cases in early arthritis clinics, posing diagnostic and management challenges. Early diagnosis is crucial to prevent long-term disability and prevent comorbidities. While classification criteria for PsA are widely accepted, the lack of specific diagnostic criteria may delay diagnosis, with many patients experiencing delays of over a year before receiving an accurate diagnosis. For this reason, the exact prevalence of PsA remains uncertain.MethodsThe MAnagement of PSoriatic Arthritis in Italy (MAPSI) project is a multicenter observational study aimed to investigate the prevalence of PsA and characteristics in an Italian cohort. This study included 454 patients diagnosed or confirmed by a rheumatologist across 25 Rheumatology Units in Italy. Data were collected on demographics, clinical features, and treatment histories. In our cohort, distinct gender differences were observed in PsA phenotype and disease impact.ResultsMen had a higher prevalence of axial involvement and were more likely to be current or former smokers, while women showed greater rates of enthesitis and reported higher perceived disease activity. Additionally, women had a higher prevalence of psychological comorbidities, whereas men had more severe skin involvement; laboratory tests were often unhelpful in diagnosing PsA, with elevated inflammatory markers in only about half of the cases.DiscussionThese findings highlight the need for gender-sensitive approaches in the management of PsA. Our findings highlight the importance of comprehensive patient evaluation, including extramuscoloskeletal manifestation with a gender-sensitive approaches, focusing on a prompt diagnosis to prevent systemic comorbidities. Real-world data, such as those provided by the MAPSI study, are essential for understanding the burden of PsA and developing effective management strategies tailored to patient characteristics.https://www.frontiersin.org/articles/10.3389/fmed.2024.1484988/fullpsoriatic arthritispsoriasisgender differencesprevalencereal world data |
| spellingShingle | Teodora Serban Giuseppina Tramontano Monica Pendolino Dario Roccatello Oscar Massimiliano Epis Florienzo Iannone Ilenia De Andres Marta Favero Nicoletta Romeo Guido Rovera Leonardo Santo Enrico Tirri Alberto Bergamini Roberta Foti Carlotta Schenone Gerolamo Bianchi Prevalence of psoriatic arthritis in Italy: insights from the multicentric MAPSI study Frontiers in Medicine psoriatic arthritis psoriasis gender differences prevalence real world data |
| title | Prevalence of psoriatic arthritis in Italy: insights from the multicentric MAPSI study |
| title_full | Prevalence of psoriatic arthritis in Italy: insights from the multicentric MAPSI study |
| title_fullStr | Prevalence of psoriatic arthritis in Italy: insights from the multicentric MAPSI study |
| title_full_unstemmed | Prevalence of psoriatic arthritis in Italy: insights from the multicentric MAPSI study |
| title_short | Prevalence of psoriatic arthritis in Italy: insights from the multicentric MAPSI study |
| title_sort | prevalence of psoriatic arthritis in italy insights from the multicentric mapsi study |
| topic | psoriatic arthritis psoriasis gender differences prevalence real world data |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1484988/full |
| work_keys_str_mv | AT teodoraserban prevalenceofpsoriaticarthritisinitalyinsightsfromthemulticentricmapsistudy AT giuseppinatramontano prevalenceofpsoriaticarthritisinitalyinsightsfromthemulticentricmapsistudy AT monicapendolino prevalenceofpsoriaticarthritisinitalyinsightsfromthemulticentricmapsistudy AT darioroccatello prevalenceofpsoriaticarthritisinitalyinsightsfromthemulticentricmapsistudy AT oscarmassimilianoepis prevalenceofpsoriaticarthritisinitalyinsightsfromthemulticentricmapsistudy AT florienzoiannone prevalenceofpsoriaticarthritisinitalyinsightsfromthemulticentricmapsistudy AT ileniadeandres prevalenceofpsoriaticarthritisinitalyinsightsfromthemulticentricmapsistudy AT martafavero prevalenceofpsoriaticarthritisinitalyinsightsfromthemulticentricmapsistudy AT nicolettaromeo prevalenceofpsoriaticarthritisinitalyinsightsfromthemulticentricmapsistudy AT guidorovera prevalenceofpsoriaticarthritisinitalyinsightsfromthemulticentricmapsistudy AT leonardosanto prevalenceofpsoriaticarthritisinitalyinsightsfromthemulticentricmapsistudy AT enricotirri prevalenceofpsoriaticarthritisinitalyinsightsfromthemulticentricmapsistudy AT albertobergamini prevalenceofpsoriaticarthritisinitalyinsightsfromthemulticentricmapsistudy AT robertafoti prevalenceofpsoriaticarthritisinitalyinsightsfromthemulticentricmapsistudy AT carlottaschenone prevalenceofpsoriaticarthritisinitalyinsightsfromthemulticentricmapsistudy AT gerolamobianchi prevalenceofpsoriaticarthritisinitalyinsightsfromthemulticentricmapsistudy |