Nonsurgical Approaches for Managing Hypersplenism in Thalassemia
Hypersplenism is a common manifestation of transfusion-dependent thalassemia. It results from extramedullary hematopoiesis and ineffective erythropoiesis. The end result of massive splenomegaly and chronic pancytopenia requiring transfusion debilitates the patient and implies a huge burden on the me...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of Applied Hematology |
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| Online Access: | https://journals.lww.com/10.4103/joah.joah_94_24 |
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| _version_ | 1841550025495150592 |
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| author | Abdullah Talal Almohammadi |
| author_facet | Abdullah Talal Almohammadi |
| author_sort | Abdullah Talal Almohammadi |
| collection | DOAJ |
| description | Hypersplenism is a common manifestation of transfusion-dependent thalassemia. It results from extramedullary hematopoiesis and ineffective erythropoiesis. The end result of massive splenomegaly and chronic pancytopenia requiring transfusion debilitates the patient and implies a huge burden on the medical system. Classically, splenectomy has been the favorable approach, but the newer pharmacological approaches reversing the pathology or the minimally invasive radiological procedure can push splenectomy as the last resort and ultimately save the patients from the morbidity associated with splenectomy. |
| format | Article |
| id | doaj-art-a822460f008b4e1ebb83e1eabeadfa8d |
| institution | Kabale University |
| issn | 1658-5127 2454-6976 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Applied Hematology |
| spelling | doaj-art-a822460f008b4e1ebb83e1eabeadfa8d2025-01-10T11:13:41ZengWolters Kluwer Medknow PublicationsJournal of Applied Hematology1658-51272454-69762024-12-0115425926210.4103/joah.joah_94_24Nonsurgical Approaches for Managing Hypersplenism in ThalassemiaAbdullah Talal AlmohammadiHypersplenism is a common manifestation of transfusion-dependent thalassemia. It results from extramedullary hematopoiesis and ineffective erythropoiesis. The end result of massive splenomegaly and chronic pancytopenia requiring transfusion debilitates the patient and implies a huge burden on the medical system. Classically, splenectomy has been the favorable approach, but the newer pharmacological approaches reversing the pathology or the minimally invasive radiological procedure can push splenectomy as the last resort and ultimately save the patients from the morbidity associated with splenectomy.https://journals.lww.com/10.4103/joah.joah_94_24hypersplenismnonsurgicalthalassemia |
| spellingShingle | Abdullah Talal Almohammadi Nonsurgical Approaches for Managing Hypersplenism in Thalassemia Journal of Applied Hematology hypersplenism nonsurgical thalassemia |
| title | Nonsurgical Approaches for Managing Hypersplenism in Thalassemia |
| title_full | Nonsurgical Approaches for Managing Hypersplenism in Thalassemia |
| title_fullStr | Nonsurgical Approaches for Managing Hypersplenism in Thalassemia |
| title_full_unstemmed | Nonsurgical Approaches for Managing Hypersplenism in Thalassemia |
| title_short | Nonsurgical Approaches for Managing Hypersplenism in Thalassemia |
| title_sort | nonsurgical approaches for managing hypersplenism in thalassemia |
| topic | hypersplenism nonsurgical thalassemia |
| url | https://journals.lww.com/10.4103/joah.joah_94_24 |
| work_keys_str_mv | AT abdullahtalalalmohammadi nonsurgicalapproachesformanaginghypersplenisminthalassemia |