Fabrication and drug release properties of curcumin-loaded silk fibroin nanofibrous membranes
This paper describes a silk fibroin-based nanofibrous membranes loaded with antitumor drugs curcumin and 5-fluorouracil using electrospinning technique. The concentration of curcumin/5-fluorouracil in the silk fibroin solution for electrospinning was optimized to be 0.15/0.25, 0.3/0.5, and 0.45/0.75...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2019-07-01
|
| Series: | Adsorption Science & Technology |
| Online Access: | https://doi.org/10.1177/0263617418820416 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841563234602057728 |
|---|---|
| author | Xusheng Xie Jia Yu Zeyu Zhao Zhaozhu Zheng Maobin Xie Xiaoqin Wang Zhifen Han Gang Li |
| author_facet | Xusheng Xie Jia Yu Zeyu Zhao Zhaozhu Zheng Maobin Xie Xiaoqin Wang Zhifen Han Gang Li |
| author_sort | Xusheng Xie |
| collection | DOAJ |
| description | This paper describes a silk fibroin-based nanofibrous membranes loaded with antitumor drugs curcumin and 5-fluorouracil using electrospinning technique. The concentration of curcumin/5-fluorouracil in the silk fibroin solution for electrospinning was optimized to be 0.15/0.25, 0.3/0.5, and 0.45/0.75 wt%. The morphology, hydrophilic property, pore size, secondary structure, and antitumor drugs release of nanofibrous membranes were measured. The diameter of nanofibrous membranes ranged about 100–200 nm. The results indicated that electrospinning process did not influence the secondary structure and the drug content of antitumor drugs, and dual drugs encapsulated in the silk fibroin nanofibrous membranes were released in a steady and consistent process. In conclusion, the silk fibroin-based drug-loaded membranes can be useful as biomaterials with antitumor function. |
| format | Article |
| id | doaj-art-a818d832c5e04d0eb07117b5152ce0bb |
| institution | Kabale University |
| issn | 0263-6174 2048-4038 |
| language | English |
| publishDate | 2019-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Adsorption Science & Technology |
| spelling | doaj-art-a818d832c5e04d0eb07117b5152ce0bb2025-01-03T00:10:27ZengSAGE PublishingAdsorption Science & Technology0263-61742048-40382019-07-013710.1177/0263617418820416Fabrication and drug release properties of curcumin-loaded silk fibroin nanofibrous membranesXusheng XieJia YuZeyu ZhaoZhaozhu ZhengMaobin XieXiaoqin WangZhifen HanGang LiThis paper describes a silk fibroin-based nanofibrous membranes loaded with antitumor drugs curcumin and 5-fluorouracil using electrospinning technique. The concentration of curcumin/5-fluorouracil in the silk fibroin solution for electrospinning was optimized to be 0.15/0.25, 0.3/0.5, and 0.45/0.75 wt%. The morphology, hydrophilic property, pore size, secondary structure, and antitumor drugs release of nanofibrous membranes were measured. The diameter of nanofibrous membranes ranged about 100–200 nm. The results indicated that electrospinning process did not influence the secondary structure and the drug content of antitumor drugs, and dual drugs encapsulated in the silk fibroin nanofibrous membranes were released in a steady and consistent process. In conclusion, the silk fibroin-based drug-loaded membranes can be useful as biomaterials with antitumor function.https://doi.org/10.1177/0263617418820416 |
| spellingShingle | Xusheng Xie Jia Yu Zeyu Zhao Zhaozhu Zheng Maobin Xie Xiaoqin Wang Zhifen Han Gang Li Fabrication and drug release properties of curcumin-loaded silk fibroin nanofibrous membranes Adsorption Science & Technology |
| title | Fabrication and drug release properties of curcumin-loaded silk fibroin nanofibrous membranes |
| title_full | Fabrication and drug release properties of curcumin-loaded silk fibroin nanofibrous membranes |
| title_fullStr | Fabrication and drug release properties of curcumin-loaded silk fibroin nanofibrous membranes |
| title_full_unstemmed | Fabrication and drug release properties of curcumin-loaded silk fibroin nanofibrous membranes |
| title_short | Fabrication and drug release properties of curcumin-loaded silk fibroin nanofibrous membranes |
| title_sort | fabrication and drug release properties of curcumin loaded silk fibroin nanofibrous membranes |
| url | https://doi.org/10.1177/0263617418820416 |
| work_keys_str_mv | AT xushengxie fabricationanddrugreleasepropertiesofcurcuminloadedsilkfibroinnanofibrousmembranes AT jiayu fabricationanddrugreleasepropertiesofcurcuminloadedsilkfibroinnanofibrousmembranes AT zeyuzhao fabricationanddrugreleasepropertiesofcurcuminloadedsilkfibroinnanofibrousmembranes AT zhaozhuzheng fabricationanddrugreleasepropertiesofcurcuminloadedsilkfibroinnanofibrousmembranes AT maobinxie fabricationanddrugreleasepropertiesofcurcuminloadedsilkfibroinnanofibrousmembranes AT xiaoqinwang fabricationanddrugreleasepropertiesofcurcuminloadedsilkfibroinnanofibrousmembranes AT zhifenhan fabricationanddrugreleasepropertiesofcurcuminloadedsilkfibroinnanofibrousmembranes AT gangli fabricationanddrugreleasepropertiesofcurcuminloadedsilkfibroinnanofibrousmembranes |