The association between oxidative balance score and sleep duration: a mediation analysis of a cross-sectional study
Study objectivesThe Oxidative Balance Score (OBS), which reflects overall oxidation through diet and lifestyle, has been linked to sleep, but few studies have clarified this relationship. We investigated the association between OBS and sleep duration, and whether oxidative stress (OS) and inflammati...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1423424/full |
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| author | Guihua Hao Guihua Hao Xiaomei Zhao Weiwei Fu Yiwen Wu Jingjing Dai Yifeng Qian Tian Xie Lili Hou Wentao Shi |
| author_facet | Guihua Hao Guihua Hao Xiaomei Zhao Weiwei Fu Yiwen Wu Jingjing Dai Yifeng Qian Tian Xie Lili Hou Wentao Shi |
| author_sort | Guihua Hao |
| collection | DOAJ |
| description | Study objectivesThe Oxidative Balance Score (OBS), which reflects overall oxidation through diet and lifestyle, has been linked to sleep, but few studies have clarified this relationship. We investigated the association between OBS and sleep duration, and whether oxidative stress (OS) and inflammation mediate the underlying mechanisms.MethodsData were obtained from the National Health and Nutrition Examination Survey spanning the years 2007 to 2018. Multivariable logistic regression analyses were used to evaluate the association between OBS and the risk of sleep duration. Mediation analyses were conducted to investigate the role of OS and inflammatory markers.ResultsA significant negative association was found between OBS and sleep duration (p < 0.01). Meanwhile, compared to participants in OBS tertile 1, the ORs (95% CIs) of incident short sleep duration were 0.78 (0.72–0.86) and 0.72 (0.67–0.79) (both p < 0.01) for OBS tertile 2 and 3, respectively. And the ORs (95% CIs) of incident long sleep duration were 0.83 (0.73, 0.95) and 0.66 (0.57, 0.75) (both p < 0.01) for OBS tertiles 2 and 3 after adjustment for multivariate variables. A linear relationship between OBS and short/long sleep duration (p for non-linearity = 0.69/0.94, both p < 0.01) were revealed. Mediation analysis showed absolute neutrophil count, serum total bilirubin mediated the association between OBS and short/long sleep duration with 5.72, 13.41% proportion of mediation, respectively (both p < 0.001).ConclusionOBS is negatively associated with sleep duration. OS and inflammatory biomarkers mediate the relationship. |
| format | Article |
| id | doaj-art-a7f25b270631466cbb53ae57f97258ee |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-a7f25b270631466cbb53ae57f97258ee2024-12-16T11:45:05ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2024-11-011110.3389/fnut.2024.14234241423424The association between oxidative balance score and sleep duration: a mediation analysis of a cross-sectional studyGuihua Hao0Guihua Hao1Xiaomei Zhao2Weiwei Fu3Yiwen Wu4Jingjing Dai5Yifeng Qian6Tian Xie7Lili Hou8Wentao Shi9Department of Nursing, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaShanghai Jiao Tong University School of Nursing, Shanghai, ChinaDepartment of Nursing, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Gastroenterology, Peking University Third Hospital, Beijing, ChinaDepartment of Nursing, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Nursing, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Oral and Craniomaxillofacial Surgery, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of General Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Nursing, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaClinical Research Unit, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaStudy objectivesThe Oxidative Balance Score (OBS), which reflects overall oxidation through diet and lifestyle, has been linked to sleep, but few studies have clarified this relationship. We investigated the association between OBS and sleep duration, and whether oxidative stress (OS) and inflammation mediate the underlying mechanisms.MethodsData were obtained from the National Health and Nutrition Examination Survey spanning the years 2007 to 2018. Multivariable logistic regression analyses were used to evaluate the association between OBS and the risk of sleep duration. Mediation analyses were conducted to investigate the role of OS and inflammatory markers.ResultsA significant negative association was found between OBS and sleep duration (p < 0.01). Meanwhile, compared to participants in OBS tertile 1, the ORs (95% CIs) of incident short sleep duration were 0.78 (0.72–0.86) and 0.72 (0.67–0.79) (both p < 0.01) for OBS tertile 2 and 3, respectively. And the ORs (95% CIs) of incident long sleep duration were 0.83 (0.73, 0.95) and 0.66 (0.57, 0.75) (both p < 0.01) for OBS tertiles 2 and 3 after adjustment for multivariate variables. A linear relationship between OBS and short/long sleep duration (p for non-linearity = 0.69/0.94, both p < 0.01) were revealed. Mediation analysis showed absolute neutrophil count, serum total bilirubin mediated the association between OBS and short/long sleep duration with 5.72, 13.41% proportion of mediation, respectively (both p < 0.001).ConclusionOBS is negatively associated with sleep duration. OS and inflammatory biomarkers mediate the relationship.https://www.frontiersin.org/articles/10.3389/fnut.2024.1423424/fullOBSsleep durationinflammationoxidative stressNHANESmediation analysis |
| spellingShingle | Guihua Hao Guihua Hao Xiaomei Zhao Weiwei Fu Yiwen Wu Jingjing Dai Yifeng Qian Tian Xie Lili Hou Wentao Shi The association between oxidative balance score and sleep duration: a mediation analysis of a cross-sectional study Frontiers in Nutrition OBS sleep duration inflammation oxidative stress NHANES mediation analysis |
| title | The association between oxidative balance score and sleep duration: a mediation analysis of a cross-sectional study |
| title_full | The association between oxidative balance score and sleep duration: a mediation analysis of a cross-sectional study |
| title_fullStr | The association between oxidative balance score and sleep duration: a mediation analysis of a cross-sectional study |
| title_full_unstemmed | The association between oxidative balance score and sleep duration: a mediation analysis of a cross-sectional study |
| title_short | The association between oxidative balance score and sleep duration: a mediation analysis of a cross-sectional study |
| title_sort | association between oxidative balance score and sleep duration a mediation analysis of a cross sectional study |
| topic | OBS sleep duration inflammation oxidative stress NHANES mediation analysis |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1423424/full |
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