Extranodal Rosai-Dorfman disease masquerading as intrathoracic invasive malignancy with ankylosing spondylitis: a case report
Abstract Introduction Rosai-Dorfman Disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is an uncommon histiocytic disorder. It may be associated with autoimmune diseases, but there are few reports of concurrent ankylosing spondylitis. RDD is typically characterized by mas...
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BMC
2024-12-01
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| Series: | Journal of Cardiothoracic Surgery |
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| Online Access: | https://doi.org/10.1186/s13019-024-03147-2 |
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| author | Jun Xu Tian Xia Zhongcheng Li Jun Zhao Sheng Ju |
| author_facet | Jun Xu Tian Xia Zhongcheng Li Jun Zhao Sheng Ju |
| author_sort | Jun Xu |
| collection | DOAJ |
| description | Abstract Introduction Rosai-Dorfman Disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is an uncommon histiocytic disorder. It may be associated with autoimmune diseases, but there are few reports of concurrent ankylosing spondylitis. RDD is typically characterized by massive bilateral and painless cervical lymphadenopathy, which can also involve extranodal sites and constitutional symptoms, but rarely affect the chest cavity. Case presentation In this report, we present a case of a patient with a suspicious invasive anterior mediastinal lesion affecting multiple blood vessels and adjacent tissues. The patient has a history of ankylosing spondylitis. Despite extensive radiological and interventional examinations, the possibility of malignancy could not be completely ruled out. Following surgical resection of the tumor, the final pathology diagnosis suggested RDD. Conclusion Our report emphasizes the importance of considering RDD in the differential diagnosis of invasive thoracic malignancies. Thoracoscopy or mediastinoscopy biopsy can improve diagnostic accuracy. Our study contributes to an improved understanding among clinicians regarding the diagnosis and treatment of intrathoracic RDD and provides relevant evidence for future exploration of potential associations between RDD and ankylosing spondylitis. |
| format | Article |
| id | doaj-art-a7e79bb92fbc48dbb0ecd69397109b12 |
| institution | Kabale University |
| issn | 1749-8090 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cardiothoracic Surgery |
| spelling | doaj-art-a7e79bb92fbc48dbb0ecd69397109b122024-12-08T12:45:48ZengBMCJournal of Cardiothoracic Surgery1749-80902024-12-011911610.1186/s13019-024-03147-2Extranodal Rosai-Dorfman disease masquerading as intrathoracic invasive malignancy with ankylosing spondylitis: a case reportJun Xu0Tian Xia1Zhongcheng Li2Jun Zhao3Sheng Ju4Department of Thoracic Surgery, The First Affiliated Hospital of Soochow UniversityDepartment of Thoracic Surgery, The First Affiliated Hospital of Soochow UniversityDepartment of Thoracic Surgery, The First Affiliated Hospital of Soochow UniversityDepartment of Thoracic Surgery, The First Affiliated Hospital of Soochow UniversityDepartment of Thoracic Surgery, The First Affiliated Hospital of Soochow UniversityAbstract Introduction Rosai-Dorfman Disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is an uncommon histiocytic disorder. It may be associated with autoimmune diseases, but there are few reports of concurrent ankylosing spondylitis. RDD is typically characterized by massive bilateral and painless cervical lymphadenopathy, which can also involve extranodal sites and constitutional symptoms, but rarely affect the chest cavity. Case presentation In this report, we present a case of a patient with a suspicious invasive anterior mediastinal lesion affecting multiple blood vessels and adjacent tissues. The patient has a history of ankylosing spondylitis. Despite extensive radiological and interventional examinations, the possibility of malignancy could not be completely ruled out. Following surgical resection of the tumor, the final pathology diagnosis suggested RDD. Conclusion Our report emphasizes the importance of considering RDD in the differential diagnosis of invasive thoracic malignancies. Thoracoscopy or mediastinoscopy biopsy can improve diagnostic accuracy. Our study contributes to an improved understanding among clinicians regarding the diagnosis and treatment of intrathoracic RDD and provides relevant evidence for future exploration of potential associations between RDD and ankylosing spondylitis.https://doi.org/10.1186/s13019-024-03147-2Rosai-Dorfman diseaseMediastinumThymusAnkylosing spondylitis |
| spellingShingle | Jun Xu Tian Xia Zhongcheng Li Jun Zhao Sheng Ju Extranodal Rosai-Dorfman disease masquerading as intrathoracic invasive malignancy with ankylosing spondylitis: a case report Journal of Cardiothoracic Surgery Rosai-Dorfman disease Mediastinum Thymus Ankylosing spondylitis |
| title | Extranodal Rosai-Dorfman disease masquerading as intrathoracic invasive malignancy with ankylosing spondylitis: a case report |
| title_full | Extranodal Rosai-Dorfman disease masquerading as intrathoracic invasive malignancy with ankylosing spondylitis: a case report |
| title_fullStr | Extranodal Rosai-Dorfman disease masquerading as intrathoracic invasive malignancy with ankylosing spondylitis: a case report |
| title_full_unstemmed | Extranodal Rosai-Dorfman disease masquerading as intrathoracic invasive malignancy with ankylosing spondylitis: a case report |
| title_short | Extranodal Rosai-Dorfman disease masquerading as intrathoracic invasive malignancy with ankylosing spondylitis: a case report |
| title_sort | extranodal rosai dorfman disease masquerading as intrathoracic invasive malignancy with ankylosing spondylitis a case report |
| topic | Rosai-Dorfman disease Mediastinum Thymus Ankylosing spondylitis |
| url | https://doi.org/10.1186/s13019-024-03147-2 |
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