In silico single-cell metabolism analysis unravels a new transition stage of CD8 T cells 4 days post-infection

In silico single-cell metabolism analysis unravels a new transition stage of CD8 T cells 4 days post-infection

CD8 T cell proper differentiation during antiviral responses relies on metabolic adaptations. Herein, we investigated global metabolic activity in single CD8 T cells along an in vivo response by estimating metabolic fluxes from single-cell RNA-sequencing data. The approach was validated by the obser...

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Bibliographic Details
Main Authors: Christophe Arpin, Franck Picard, Olivier Gandrillon
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:ImmunoInformatics
Subjects:
Single-cell mRNA sequencing
Metabolism
CD8 T cells
In silico analyses
Gene expression variability
Antiviral response
Online Access:http://www.sciencedirect.com/science/article/pii/S2667119024000089
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