In silico single-cell metabolism analysis unravels a new transition stage of CD8 T cells 4 days post-infection
CD8 T cell proper differentiation during antiviral responses relies on metabolic adaptations. Herein, we investigated global metabolic activity in single CD8 T cells along an in vivo response by estimating metabolic fluxes from single-cell RNA-sequencing data. The approach was validated by the obser...
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| Language: | English |
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Elsevier
2024-06-01
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| Series: | ImmunoInformatics |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667119024000089 |
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| author | Christophe Arpin Franck Picard Olivier Gandrillon |
| author_facet | Christophe Arpin Franck Picard Olivier Gandrillon |
| author_sort | Christophe Arpin |
| collection | DOAJ |
| description | CD8 T cell proper differentiation during antiviral responses relies on metabolic adaptations. Herein, we investigated global metabolic activity in single CD8 T cells along an in vivo response by estimating metabolic fluxes from single-cell RNA-sequencing data. The approach was validated by the observation of metabolic variations known from experimental studies on global cell populations, while adding temporally detailed information and unravelling yet undescribed sections of CD8 T cell metabolism that are affected by cellular differentiation. Furthermore, inter-cellular variability in gene expression level, highlighted by single cell data, and heterogeneity of metabolic activity 4 days post-infection, revealed a new transition stage accompanied by a metabolic switch in activated cells differentiating into full-blown effectors. |
| format | Article |
| id | doaj-art-a7c76c79cc2f439ca10b06deae56b7dc |
| institution | Kabale University |
| issn | 2667-1190 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | ImmunoInformatics |
| spelling | doaj-art-a7c76c79cc2f439ca10b06deae56b7dc2025-01-10T04:38:26ZengElsevierImmunoInformatics2667-11902024-06-0114100038In silico single-cell metabolism analysis unravels a new transition stage of CD8 T cells 4 days post-infectionChristophe Arpin0Franck Picard1Olivier Gandrillon2Laboratory of Biology and Modeling of the Cell, Université de Lyon, ENS de Lyon, Université Claude Bernard, CNRS UMR 5239, INSERM U1210, Lyon, France; Centre International de recherche en Infectiologie, Université de Lyon, ENS de Lyon, Université Claude Bernard, CNRS UMR 5308, INSERM U1111, Lyon, France; Corresponding author at: ENS de LYON – LBMC – SBDM team – 46, allé d'Italie – 69364 Lyon Cedex 07 – France.Laboratory of Biology and Modeling of the Cell, Université de Lyon, ENS de Lyon, Université Claude Bernard, CNRS UMR 5239, INSERM U1210, Lyon, FranceLaboratory of Biology and Modeling of the Cell, Université de Lyon, ENS de Lyon, Université Claude Bernard, CNRS UMR 5239, INSERM U1210, Lyon, France; Inria, FranceCD8 T cell proper differentiation during antiviral responses relies on metabolic adaptations. Herein, we investigated global metabolic activity in single CD8 T cells along an in vivo response by estimating metabolic fluxes from single-cell RNA-sequencing data. The approach was validated by the observation of metabolic variations known from experimental studies on global cell populations, while adding temporally detailed information and unravelling yet undescribed sections of CD8 T cell metabolism that are affected by cellular differentiation. Furthermore, inter-cellular variability in gene expression level, highlighted by single cell data, and heterogeneity of metabolic activity 4 days post-infection, revealed a new transition stage accompanied by a metabolic switch in activated cells differentiating into full-blown effectors.http://www.sciencedirect.com/science/article/pii/S2667119024000089Single-cell mRNA sequencingMetabolismCD8 T cellsIn silico analysesGene expression variabilityAntiviral response |
| spellingShingle | Christophe Arpin Franck Picard Olivier Gandrillon In silico single-cell metabolism analysis unravels a new transition stage of CD8 T cells 4 days post-infection ImmunoInformatics Single-cell mRNA sequencing Metabolism CD8 T cells In silico analyses Gene expression variability Antiviral response |
| title | In silico single-cell metabolism analysis unravels a new transition stage of CD8 T cells 4 days post-infection |
| title_full | In silico single-cell metabolism analysis unravels a new transition stage of CD8 T cells 4 days post-infection |
| title_fullStr | In silico single-cell metabolism analysis unravels a new transition stage of CD8 T cells 4 days post-infection |
| title_full_unstemmed | In silico single-cell metabolism analysis unravels a new transition stage of CD8 T cells 4 days post-infection |
| title_short | In silico single-cell metabolism analysis unravels a new transition stage of CD8 T cells 4 days post-infection |
| title_sort | in silico single cell metabolism analysis unravels a new transition stage of cd8 t cells 4 days post infection |
| topic | Single-cell mRNA sequencing Metabolism CD8 T cells In silico analyses Gene expression variability Antiviral response |
| url | http://www.sciencedirect.com/science/article/pii/S2667119024000089 |
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