Broadening horizons: the multifaceted role of ferroptosis in breast cancer
Breast cancer poses a serious threat to women’s health globally. Current radiotherapy and chemotherapy regimens can induce drug-resistance effects in cancer tissues, such as anti-apoptosis, anti-pyroptosis, and anti-necroptosis, leading to poor clinical outcomes in the treatment of breast cancer. Fe...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1455741/full |
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| author | Anqi Ge Wang Xiang Yan Li Da Zhao Junpeng Chen Junpeng Chen Junpeng Chen Pawan Daga Charles C. Dai Charles C. Dai Kailin Yang Kailin Yang Yexing Yan Moujia Hao Bolin Zhang Wei Xiao |
| author_facet | Anqi Ge Wang Xiang Yan Li Da Zhao Junpeng Chen Junpeng Chen Junpeng Chen Pawan Daga Charles C. Dai Charles C. Dai Kailin Yang Kailin Yang Yexing Yan Moujia Hao Bolin Zhang Wei Xiao |
| author_sort | Anqi Ge |
| collection | DOAJ |
| description | Breast cancer poses a serious threat to women’s health globally. Current radiotherapy and chemotherapy regimens can induce drug-resistance effects in cancer tissues, such as anti-apoptosis, anti-pyroptosis, and anti-necroptosis, leading to poor clinical outcomes in the treatment of breast cancer. Ferroptosis is a novel programmed cell death modality characterized by iron overload, excessive generation of reactive oxygen species, and membrane lipid peroxidation. The occurrence of ferroptosis results from the imbalance between intracellular peroxidation mechanisms (executive system) and antioxidant mechanisms (defensive system), specifically involving iron metabolism pathways, amino acid metabolism pathways, and lipid metabolism pathways. In recent years, it has been found that ferroptosis is associated with the progression of various diseases, including tumors, hypertension, diabetes, and Alzheimer’s disease. Studies have confirmed that triggering ferroptosis in breast cancer cells can significantly inhibit cancer cell proliferation and invasion, and improve cancer cell sensitivity to radiotherapy and chemotherapy, making induction of ferroptosis a potential strategy for the treatment of breast cancer. This paper reviews the development of the concept of ferroptosis, the mechanisms of ferroptosis (including signaling pathways such as GSH-GPX4, FSP1-CoQ1, DHODH-CoQ10, and GCH1-BH4) in breast cancer disease, the latest research progress, and summarizes the research on ferroptosis in breast cancer disease within the framework of metabolism, reactive oxygen biology, and iron biology. The key regulatory factors and mechanisms of ferroptosis in breast cancer disease, as well as important concepts and significant open questions in the field of ferroptosis and related natural compounds, are introduced. It is hoped that future research will make further breakthroughs in the regulatory mechanisms of ferroptosis and the use of ferroptosis in treating breast cancer cells. Meanwhile, natural compounds may also become a new direction for potential drug development targeting ferroptosis in breast cancer treatment. This provides a theoretical basis and opens up a new pathway for research and the development of drugs for the prevention and treatment of breast cancer. |
| format | Article |
| id | doaj-art-a7bf41f67c364b9c8570c6327182a7a5 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Immunology |
| spelling | doaj-art-a7bf41f67c364b9c8570c6327182a7a52024-11-27T06:33:09ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-11-011510.3389/fimmu.2024.14557411455741Broadening horizons: the multifaceted role of ferroptosis in breast cancerAnqi Ge0Wang Xiang1Yan Li2Da Zhao3Junpeng Chen4Junpeng Chen5Junpeng Chen6Pawan Daga7Charles C. Dai8Charles C. Dai9Kailin Yang10Kailin Yang11Yexing Yan12Moujia Hao13Bolin Zhang14Wei Xiao15The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, ChinaDepartment of Rheumatology, The First People’s Hospital Changde City, Changde, Hunan, ChinaPeople's Hospital of Ningxiang City, Ningxiang, ChinaThe First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, ChinaPsychosomatic Laboratory, Department of Psychiatry, Daqing Hospital of Traditional Chinese Medicine, Daqing, ChinaDepartment of Physiology, School of Medicine, University of Louisville, Louisville, KY, United StatesTong Jiecheng Studio, Hunan University of Science and Technology, Xiangtan, ChinaDepartment of Internal Medicine, University of Louisville, Louisville, KY, United StatesDepartment of Oral and Maxillofacial Surgery, University of Maryland School of Dentistry, Baltimore, MD, United StatesFischell Department of Bioengineering, A. James Clark School of Engineering, University of Maryland, College Park, MD, United StatesPsychosomatic Laboratory, Department of Psychiatry, Daqing Hospital of Traditional Chinese Medicine, Daqing, China0Hunan University of Chinese Medicine, Changsha, Hunan, ChinaPsychosomatic Laboratory, Department of Psychiatry, Daqing Hospital of Traditional Chinese Medicine, Daqing, ChinaPsychosomatic Laboratory, Department of Psychiatry, Daqing Hospital of Traditional Chinese Medicine, Daqing, China1Hainan Normal University, Haikou, ChinaDepartment of Rheumatology, The First People’s Hospital Changde City, Changde, Hunan, ChinaBreast cancer poses a serious threat to women’s health globally. Current radiotherapy and chemotherapy regimens can induce drug-resistance effects in cancer tissues, such as anti-apoptosis, anti-pyroptosis, and anti-necroptosis, leading to poor clinical outcomes in the treatment of breast cancer. Ferroptosis is a novel programmed cell death modality characterized by iron overload, excessive generation of reactive oxygen species, and membrane lipid peroxidation. The occurrence of ferroptosis results from the imbalance between intracellular peroxidation mechanisms (executive system) and antioxidant mechanisms (defensive system), specifically involving iron metabolism pathways, amino acid metabolism pathways, and lipid metabolism pathways. In recent years, it has been found that ferroptosis is associated with the progression of various diseases, including tumors, hypertension, diabetes, and Alzheimer’s disease. Studies have confirmed that triggering ferroptosis in breast cancer cells can significantly inhibit cancer cell proliferation and invasion, and improve cancer cell sensitivity to radiotherapy and chemotherapy, making induction of ferroptosis a potential strategy for the treatment of breast cancer. This paper reviews the development of the concept of ferroptosis, the mechanisms of ferroptosis (including signaling pathways such as GSH-GPX4, FSP1-CoQ1, DHODH-CoQ10, and GCH1-BH4) in breast cancer disease, the latest research progress, and summarizes the research on ferroptosis in breast cancer disease within the framework of metabolism, reactive oxygen biology, and iron biology. The key regulatory factors and mechanisms of ferroptosis in breast cancer disease, as well as important concepts and significant open questions in the field of ferroptosis and related natural compounds, are introduced. It is hoped that future research will make further breakthroughs in the regulatory mechanisms of ferroptosis and the use of ferroptosis in treating breast cancer cells. Meanwhile, natural compounds may also become a new direction for potential drug development targeting ferroptosis in breast cancer treatment. This provides a theoretical basis and opens up a new pathway for research and the development of drugs for the prevention and treatment of breast cancer.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1455741/fullbreast canceriron metabolismferroptosisreactive oxygen speciesinflammation |
| spellingShingle | Anqi Ge Wang Xiang Yan Li Da Zhao Junpeng Chen Junpeng Chen Junpeng Chen Pawan Daga Charles C. Dai Charles C. Dai Kailin Yang Kailin Yang Yexing Yan Moujia Hao Bolin Zhang Wei Xiao Broadening horizons: the multifaceted role of ferroptosis in breast cancer Frontiers in Immunology breast cancer iron metabolism ferroptosis reactive oxygen species inflammation |
| title | Broadening horizons: the multifaceted role of ferroptosis in breast cancer |
| title_full | Broadening horizons: the multifaceted role of ferroptosis in breast cancer |
| title_fullStr | Broadening horizons: the multifaceted role of ferroptosis in breast cancer |
| title_full_unstemmed | Broadening horizons: the multifaceted role of ferroptosis in breast cancer |
| title_short | Broadening horizons: the multifaceted role of ferroptosis in breast cancer |
| title_sort | broadening horizons the multifaceted role of ferroptosis in breast cancer |
| topic | breast cancer iron metabolism ferroptosis reactive oxygen species inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1455741/full |
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