The deprivation cascade hypothesis of dementia

There are significant disparities in dementia risk and care burden in the global population. This review provides evidence of the effects of deprivation, understood as the absence of environmental resources required for brain health. Deprivation increases dementia risk and care burden due to biologi...

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Main Author: Timothy Daly
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Aging and Health Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2667032124000404
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author Timothy Daly
author_facet Timothy Daly
author_sort Timothy Daly
collection DOAJ
description There are significant disparities in dementia risk and care burden in the global population. This review provides evidence of the effects of deprivation, understood as the absence of environmental resources required for brain health. Deprivation increases dementia risk and care burden due to biological, environmental, and social dimensions of risk. It is hypothesized that the major mediator between deprivation and dementia is reduced educational and professional attainment. It argues for structural interventions centered around improved attainment, particularly for girls and women across the globe, improved funding for primary and social care, and a rights-based approach to brain health to improve access to these resources and thereby reduce dementia disparities.
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spelling doaj-art-a7b383b42c8040e6b12946c9d1fffc6f2025-01-04T04:57:19ZengElsevierAging and Health Research2667-03212025-03-0151100219The deprivation cascade hypothesis of dementiaTimothy Daly0UMR 1219, Bordeaux Population Health, University of Bordeaux & INSERM, Bordeaux, France; Bioethics Program, FLACSO Argentina, Tucumán 1966, C1050 AAN, Buenos Aires, Argentina; Corresponding author at: UMR 1219 Bordeaux Population Health, Université de Bordeaux & INSERM, 146 rue Léo Saignat, 33076 Bordeaux, France.There are significant disparities in dementia risk and care burden in the global population. This review provides evidence of the effects of deprivation, understood as the absence of environmental resources required for brain health. Deprivation increases dementia risk and care burden due to biological, environmental, and social dimensions of risk. It is hypothesized that the major mediator between deprivation and dementia is reduced educational and professional attainment. It argues for structural interventions centered around improved attainment, particularly for girls and women across the globe, improved funding for primary and social care, and a rights-based approach to brain health to improve access to these resources and thereby reduce dementia disparities.http://www.sciencedirect.com/science/article/pii/S2667032124000404DementiaPreventionCascadeSocial determinants of healthBrain health
spellingShingle Timothy Daly
The deprivation cascade hypothesis of dementia
Aging and Health Research
Dementia
Prevention
Cascade
Social determinants of health
Brain health
title The deprivation cascade hypothesis of dementia
title_full The deprivation cascade hypothesis of dementia
title_fullStr The deprivation cascade hypothesis of dementia
title_full_unstemmed The deprivation cascade hypothesis of dementia
title_short The deprivation cascade hypothesis of dementia
title_sort deprivation cascade hypothesis of dementia
topic Dementia
Prevention
Cascade
Social determinants of health
Brain health
url http://www.sciencedirect.com/science/article/pii/S2667032124000404
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