Alternating magnetic field guiding system for MNP hyperthermia treatment of deep-seated cancers
Objectives Demonstrate the potential application of a novel, endoscope-like device to guide and focus an alternating magnetic field (AMF) for treating deep-seated cancers via magnetic nanoparticle hyperthermia (MNPH).Methods AMF delivery, MNP activation, and eddy current distribution characteristics...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2024.2391008 |
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| author | Robert V. Stigliano Ilona Danelyan Giga Gabriadze Levan Shoshiashvili Ian Baker P. Jack Hoopes Roman Jobava Fridon Shubitidze |
| author_facet | Robert V. Stigliano Ilona Danelyan Giga Gabriadze Levan Shoshiashvili Ian Baker P. Jack Hoopes Roman Jobava Fridon Shubitidze |
| author_sort | Robert V. Stigliano |
| collection | DOAJ |
| description | Objectives Demonstrate the potential application of a novel, endoscope-like device to guide and focus an alternating magnetic field (AMF) for treating deep-seated cancers via magnetic nanoparticle hyperthermia (MNPH).Methods AMF delivery, MNP activation, and eddy current distribution characteristics are investigated through experimental studies in phantoms and computational simulations using a full 3-dimensional human model. The 3D simulations compare the novel device to traditional AMF designs, including a MagForce-like, two-coil system (used clinically) and a single surface-coil system.Results The results demonstrate that this approach can deliver the same magnetic field strength at the prostate’s centroid as traditional AMF designs, while reducing eddy current heating by 2 to 6 times. At the same level of normal tissue heating, this method provides 5.0 times, 1.5 times, and 0.92 times the magnetic field strength to the nearest, centroid, and farthest regions of the prostate, respectively.Conclusions These results demonstrate proof-of-concept for an endoscopic magnetic field guiding and focusing system capable of delivering clinically relevant AMF from a distance. This innovative approach offers a promising alternative to conventional field delivery methods by directing AMF through the body, concentrating it in the tumor region, reducing eddy currents in surrounding healthy tissue, and avoiding exposure of nearby metallic implants. |
| format | Article |
| id | doaj-art-a7ada2bf3fd040bc9ae14af3f359e587 |
| institution | Kabale University |
| issn | 0265-6736 1464-5157 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj-art-a7ada2bf3fd040bc9ae14af3f359e5872025-01-03T09:30:27ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572024-12-0141110.1080/02656736.2024.2391008Alternating magnetic field guiding system for MNP hyperthermia treatment of deep-seated cancersRobert V. Stigliano0Ilona Danelyan1Giga Gabriadze2Levan Shoshiashvili3Ian Baker4P. Jack Hoopes5Roman Jobava6Fridon Shubitidze7Faraday Systems Design LLC, Austin, TX, USAEMCoS LTD, Tbilisi, GeorgiaEMCoS LTD, Tbilisi, GeorgiaDepartment of Electrical and Electronics Engineering, Faculty of Exact and Natural Sciences, Ivane Javakhishvili Tbilisi State University, Tbilisi, GeorgiaThayer School of Engineering at Dartmouth College, Hanover, NH, USAThayer School of Engineering at Dartmouth College, Hanover, NH, USAEMCoS LTD, Tbilisi, GeorgiaThayer School of Engineering at Dartmouth College, Hanover, NH, USAObjectives Demonstrate the potential application of a novel, endoscope-like device to guide and focus an alternating magnetic field (AMF) for treating deep-seated cancers via magnetic nanoparticle hyperthermia (MNPH).Methods AMF delivery, MNP activation, and eddy current distribution characteristics are investigated through experimental studies in phantoms and computational simulations using a full 3-dimensional human model. The 3D simulations compare the novel device to traditional AMF designs, including a MagForce-like, two-coil system (used clinically) and a single surface-coil system.Results The results demonstrate that this approach can deliver the same magnetic field strength at the prostate’s centroid as traditional AMF designs, while reducing eddy current heating by 2 to 6 times. At the same level of normal tissue heating, this method provides 5.0 times, 1.5 times, and 0.92 times the magnetic field strength to the nearest, centroid, and farthest regions of the prostate, respectively.Conclusions These results demonstrate proof-of-concept for an endoscopic magnetic field guiding and focusing system capable of delivering clinically relevant AMF from a distance. This innovative approach offers a promising alternative to conventional field delivery methods by directing AMF through the body, concentrating it in the tumor region, reducing eddy currents in surrounding healthy tissue, and avoiding exposure of nearby metallic implants.https://www.tandfonline.com/doi/10.1080/02656736.2024.2391008Magnetic nanoparticle hyperthermiaeddy currentsdeep-seated cancersnovel endoscopic deviceelectromagnetic (EM) and thermal modeling |
| spellingShingle | Robert V. Stigliano Ilona Danelyan Giga Gabriadze Levan Shoshiashvili Ian Baker P. Jack Hoopes Roman Jobava Fridon Shubitidze Alternating magnetic field guiding system for MNP hyperthermia treatment of deep-seated cancers International Journal of Hyperthermia Magnetic nanoparticle hyperthermia eddy currents deep-seated cancers novel endoscopic device electromagnetic (EM) and thermal modeling |
| title | Alternating magnetic field guiding system for MNP hyperthermia treatment of deep-seated cancers |
| title_full | Alternating magnetic field guiding system for MNP hyperthermia treatment of deep-seated cancers |
| title_fullStr | Alternating magnetic field guiding system for MNP hyperthermia treatment of deep-seated cancers |
| title_full_unstemmed | Alternating magnetic field guiding system for MNP hyperthermia treatment of deep-seated cancers |
| title_short | Alternating magnetic field guiding system for MNP hyperthermia treatment of deep-seated cancers |
| title_sort | alternating magnetic field guiding system for mnp hyperthermia treatment of deep seated cancers |
| topic | Magnetic nanoparticle hyperthermia eddy currents deep-seated cancers novel endoscopic device electromagnetic (EM) and thermal modeling |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2024.2391008 |
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