A study of long-term GABA and high-energy phosphate alterations in the primary motor cortex using anodal tDCS and 1H/31P MR spectroscopy
IntroductionAnodal transcranial direct current stimulation (tDCS) has been reported to modulate gamma-aminobutyric acid levels and cerebral energy consumption in the brain. This study aims to investigate long-term GABA and cerebral energy modulation following anodal tDCS over the primary motor corte...
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Frontiers Media S.A.
2024-12-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2024.1461417/full |
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| author | Harshal Jayeshkumar Patel Lea-Sophie Stollberg Chang-Hoon Choi Michael A. Nitsche N. Jon Shah N. Jon Shah N. Jon Shah N. Jon Shah Ferdinand Binkofski Ferdinand Binkofski Ferdinand Binkofski |
| author_facet | Harshal Jayeshkumar Patel Lea-Sophie Stollberg Chang-Hoon Choi Michael A. Nitsche N. Jon Shah N. Jon Shah N. Jon Shah N. Jon Shah Ferdinand Binkofski Ferdinand Binkofski Ferdinand Binkofski |
| author_sort | Harshal Jayeshkumar Patel |
| collection | DOAJ |
| description | IntroductionAnodal transcranial direct current stimulation (tDCS) has been reported to modulate gamma-aminobutyric acid levels and cerebral energy consumption in the brain. This study aims to investigate long-term GABA and cerebral energy modulation following anodal tDCS over the primary motor cortex.MethodTo assess GABA and energy level changes, proton and phosphorus magnetic resonance spectroscopy data were acquired before and after anodal or sham tDCS. In anodal stimulation, a 1 mA current was applied for 20 min, and the duration of ramping the current up/down at the start and end of the intervention was 10 s. In the sham-stimulation condition, the current was first ramped up over a period of 10 s, then immediately ramped down, and the condition was maintained for the next 20 min.ResultsThe GABA concentration increased significantly following anodal stimulation in the first and second post-stimulation measurements. Likewise, both ATP/Pi and PCr/Pi ratios increased after anodal stimulation in the first and second post-stimulation measurements.ConclusionThe approach employed in this study shows the feasibility of measuring long-term modulation of GABA and high-energy phosphates following anodal tDCS targeting the left M1, offering valuable insights into the mechanisms of neuroplasticity and energy metabolism, which may have implications for applications of this intervention in clinical populations. |
| format | Article |
| id | doaj-art-a7a93ab28372476b870e3027d4c00f9a |
| institution | Kabale University |
| issn | 1662-5161 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Human Neuroscience |
| spelling | doaj-art-a7a93ab28372476b870e3027d4c00f9a2024-12-13T12:01:36ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612024-12-011810.3389/fnhum.2024.14614171461417A study of long-term GABA and high-energy phosphate alterations in the primary motor cortex using anodal tDCS and 1H/31P MR spectroscopyHarshal Jayeshkumar Patel0Lea-Sophie Stollberg1Chang-Hoon Choi2Michael A. Nitsche3N. Jon Shah4N. Jon Shah5N. Jon Shah6N. Jon Shah7Ferdinand Binkofski8Ferdinand Binkofski9Ferdinand Binkofski10Division of Clinical Cognitive Sciences, Department of Neurology, RWTH Aachen University Hospital, Aachen, GermanyDivision of Clinical Cognitive Sciences, Department of Neurology, RWTH Aachen University Hospital, Aachen, GermanyInstitute of Neuroscience and Medicine-4, Forschungszentrum Jülich GmbH, Jülich, GermanyLeibniz Research Centre for Working Environment and Human Factors, Department of Psychology and Neurosciences, Dortmund, GermanyInstitute of Neuroscience and Medicine-4, Forschungszentrum Jülich GmbH, Jülich, GermanyJARA-BRAIN-Translational Medicine, Jülich-Aachen-Research-Alliance (JARA), Aachen, GermanyDepartment of Neurology, RWTH Aachen University Hospital, Aachen, GermanyInstitute of Neuroscience and Medicine-11, Forschungszentrum Juelich, Jülich, GermanyDivision of Clinical Cognitive Sciences, Department of Neurology, RWTH Aachen University Hospital, Aachen, GermanyInstitute of Neuroscience and Medicine-4, Forschungszentrum Jülich GmbH, Jülich, GermanyJARA-BRAIN-Translational Medicine, Jülich-Aachen-Research-Alliance (JARA), Aachen, GermanyIntroductionAnodal transcranial direct current stimulation (tDCS) has been reported to modulate gamma-aminobutyric acid levels and cerebral energy consumption in the brain. This study aims to investigate long-term GABA and cerebral energy modulation following anodal tDCS over the primary motor cortex.MethodTo assess GABA and energy level changes, proton and phosphorus magnetic resonance spectroscopy data were acquired before and after anodal or sham tDCS. In anodal stimulation, a 1 mA current was applied for 20 min, and the duration of ramping the current up/down at the start and end of the intervention was 10 s. In the sham-stimulation condition, the current was first ramped up over a period of 10 s, then immediately ramped down, and the condition was maintained for the next 20 min.ResultsThe GABA concentration increased significantly following anodal stimulation in the first and second post-stimulation measurements. Likewise, both ATP/Pi and PCr/Pi ratios increased after anodal stimulation in the first and second post-stimulation measurements.ConclusionThe approach employed in this study shows the feasibility of measuring long-term modulation of GABA and high-energy phosphates following anodal tDCS targeting the left M1, offering valuable insights into the mechanisms of neuroplasticity and energy metabolism, which may have implications for applications of this intervention in clinical populations.https://www.frontiersin.org/articles/10.3389/fnhum.2024.1461417/fulltDCSGABA31PMRS1HMRSprimary motor cortexneuroplasticity |
| spellingShingle | Harshal Jayeshkumar Patel Lea-Sophie Stollberg Chang-Hoon Choi Michael A. Nitsche N. Jon Shah N. Jon Shah N. Jon Shah N. Jon Shah Ferdinand Binkofski Ferdinand Binkofski Ferdinand Binkofski A study of long-term GABA and high-energy phosphate alterations in the primary motor cortex using anodal tDCS and 1H/31P MR spectroscopy Frontiers in Human Neuroscience tDCS GABA 31PMRS 1HMRS primary motor cortex neuroplasticity |
| title | A study of long-term GABA and high-energy phosphate alterations in the primary motor cortex using anodal tDCS and 1H/31P MR spectroscopy |
| title_full | A study of long-term GABA and high-energy phosphate alterations in the primary motor cortex using anodal tDCS and 1H/31P MR spectroscopy |
| title_fullStr | A study of long-term GABA and high-energy phosphate alterations in the primary motor cortex using anodal tDCS and 1H/31P MR spectroscopy |
| title_full_unstemmed | A study of long-term GABA and high-energy phosphate alterations in the primary motor cortex using anodal tDCS and 1H/31P MR spectroscopy |
| title_short | A study of long-term GABA and high-energy phosphate alterations in the primary motor cortex using anodal tDCS and 1H/31P MR spectroscopy |
| title_sort | study of long term gaba and high energy phosphate alterations in the primary motor cortex using anodal tdcs and 1h 31p mr spectroscopy |
| topic | tDCS GABA 31PMRS 1HMRS primary motor cortex neuroplasticity |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2024.1461417/full |
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