In-Silico discovery of 17alpha-hydroxywithanolide-D as potential neuroprotective allosteric modulator of NMDA receptor targeting Alzheimer’s disease

In-Silico discovery of 17alpha-hydroxywithanolide-D as potential neuroprotective allosteric modulator of NMDA receptor targeting Alzheimer’s disease

Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder marked by cognitive decline, memory impairment, and behavioral alterations. The N-methyl-D-aspartate (NMDA) receptor has emerged as a promising target for AD pharmacotherapy due to its role in the disease’s pathogenesis. T...

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Bibliographic Details
Main Authors: Manoj Kumar Vashisth, Junkai Hu, Mingrui Liu, Syed Hussain Basha, Chen Yu, Wenhua Huang
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Alzheimer’s disease
N-methyl-D-aspartate receptor
Withania somnifera
Virtual screening
Docking
Molecular dynamics
Online Access:https://doi.org/10.1038/s41598-024-78975-2
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