Patterned electrical brain stimulation by a wireless network of implantable microdevices
Abstract Transmitting meaningful information into brain circuits by electronic means is a challenge facing brain-computer interfaces. A key goal is to find an approach to inject spatially structured local current stimuli across swaths of sensory areas of the cortex. Here, we introduce a wireless app...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-54542-1 |
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| author | Ah-Hyoung Lee Jihun Lee Vincent Leung Lawrence Larson Arto Nurmikko |
| author_facet | Ah-Hyoung Lee Jihun Lee Vincent Leung Lawrence Larson Arto Nurmikko |
| author_sort | Ah-Hyoung Lee |
| collection | DOAJ |
| description | Abstract Transmitting meaningful information into brain circuits by electronic means is a challenge facing brain-computer interfaces. A key goal is to find an approach to inject spatially structured local current stimuli across swaths of sensory areas of the cortex. Here, we introduce a wireless approach to multipoint patterned electrical microstimulation by a spatially distributed epicortically implanted network of silicon microchips to target specific areas of the cortex. Each sub-millimeter-sized microchip harvests energy from an external radio-frequency source and converts this into biphasic current injected focally into tissue by a pair of integrated microwires. The amplitude, period, and repetition rate of injected current from each chip are controlled across the implant network by implementing a pre-scheduled, collision-free bitmap wireless communication protocol featuring sub-millisecond latency. As a proof-of-concept technology demonstration, a network of 30 wireless stimulators was chronically implanted into motor and sensory areas of the cortex in a freely moving rat for three months. We explored the effects of patterned intracortical electrical stimulation on trained animal behavior at average RF powers well below regulatory safety limits. |
| format | Article |
| id | doaj-art-a78cebc5d0c948ebb0f13d9512ce51a8 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-a78cebc5d0c948ebb0f13d9512ce51a82025-01-12T12:29:38ZengNature PortfolioNature Communications2041-17232024-11-0115111410.1038/s41467-024-54542-1Patterned electrical brain stimulation by a wireless network of implantable microdevicesAh-Hyoung Lee0Jihun Lee1Vincent Leung2Lawrence Larson3Arto Nurmikko4School of Engineering, Brown UniversitySchool of Engineering, Brown UniversityElectrical and Computer Engineering, Baylor UniversitySchool of Engineering, Brown UniversitySchool of Engineering, Brown UniversityAbstract Transmitting meaningful information into brain circuits by electronic means is a challenge facing brain-computer interfaces. A key goal is to find an approach to inject spatially structured local current stimuli across swaths of sensory areas of the cortex. Here, we introduce a wireless approach to multipoint patterned electrical microstimulation by a spatially distributed epicortically implanted network of silicon microchips to target specific areas of the cortex. Each sub-millimeter-sized microchip harvests energy from an external radio-frequency source and converts this into biphasic current injected focally into tissue by a pair of integrated microwires. The amplitude, period, and repetition rate of injected current from each chip are controlled across the implant network by implementing a pre-scheduled, collision-free bitmap wireless communication protocol featuring sub-millisecond latency. As a proof-of-concept technology demonstration, a network of 30 wireless stimulators was chronically implanted into motor and sensory areas of the cortex in a freely moving rat for three months. We explored the effects of patterned intracortical electrical stimulation on trained animal behavior at average RF powers well below regulatory safety limits.https://doi.org/10.1038/s41467-024-54542-1 |
| spellingShingle | Ah-Hyoung Lee Jihun Lee Vincent Leung Lawrence Larson Arto Nurmikko Patterned electrical brain stimulation by a wireless network of implantable microdevices Nature Communications |
| title | Patterned electrical brain stimulation by a wireless network of implantable microdevices |
| title_full | Patterned electrical brain stimulation by a wireless network of implantable microdevices |
| title_fullStr | Patterned electrical brain stimulation by a wireless network of implantable microdevices |
| title_full_unstemmed | Patterned electrical brain stimulation by a wireless network of implantable microdevices |
| title_short | Patterned electrical brain stimulation by a wireless network of implantable microdevices |
| title_sort | patterned electrical brain stimulation by a wireless network of implantable microdevices |
| url | https://doi.org/10.1038/s41467-024-54542-1 |
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